Protective Role of NS1-Specific Antibodies in the Immune Response to Dengue Virus Through Antibody-Dependent Cellular Cytotoxicity

• Published in: The Journal of infectious diseases Vol. 230; no. 5; pp. 1147 - 1156
• Main Authors: Sanchez-Vargas, Luis A, Mathew, Anuja, Salje, Henrik, Sousa, David, Casale, Nicole A, Farmer, Aaron, Buddhari, Darunee, Anderson, Kathryn, Iamsirithaworn, Sopon, Kaewhiran, Surachai, Friberg, Heather, Currier, Jeffrey R, Rothman, Alan L
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 15.11.2024
• Subjects: Adult; Antibodies; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antibody-Dependent Cell Cytotoxicity - immunology; Cell activation; Cell surface; Cross Reactions - immunology; Cytotoxicity; Dengue - immunology; Dengue fever; Dengue Virus - immunology; Female; Humans; Immune response; Immunogenicity; Infections; Killer Cells, Natural - immunology; Major; Male; Natural killer cells; NS1 protein; Prospective Studies; Proteins; Viral Nonstructural Proteins - immunology; nonstructural protein 1 (NS1); antibody-dependent cellular cytotoxicity (ADCC); dengue; NK cell activation

Abstract Background Dengue virus (DENV) nonstructural protein 1 (NS1) has multiple functions within infected cells, on the cell surface, and in secreted form, and is highly immunogenic. Immunity from previous DENV infections is known to exert both positive and negative effects on subsequent DENV inf...