Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans

• Published in: Diabetes (New York, N.Y.) Vol. 67; no. 4; pp. 636 - 650
• Main Authors: Tubbs, Emily, Chanon, Stéphanie, Robert, Maud, Bendridi, Nadia, Bidaux, Gabriel, Chauvin, Marie-Agnès, Ji-Cao, Jingwei, Durand, Christine, Gauvrit-Ramette, Daphné, Vidal, Hubert, Lefai, Etienne, Rieusset, Jennifer
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.04.2018
• Subjects: Animal models; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Endoplasmic reticulum; Glucose; Homeostasis; Insulin; Insulin resistance; Life Sciences; Mitochondria; Muscular system; Myotubes; Obesity; Palmitic acid; Skeletal muscle; Structure-function relationships; homeostasis; stress; differentiation; calcium; ca2+ release; contact; Endocrinology & Metabolism; human skeletal-muscle; glucose-transport; er; dysfunction

Modifications of the interactions between endoplasmic reticulum (ER) and mitochondria, defined as mitochondria-associated membranes (MAMs), were recently shown to be involved in the control of hepatic insulin action and glucose homeostasis, but with conflicting results. Whereas skeletal muscle is th...