Time course of signaling profiles of blood leukocytes in acute pancreatitis and sepsis

• Published in: Scandinavian journal of clinical and laboratory investigation Vol. 80; no. 2; pp. 114 - 123
• Main Authors: Turunen, Antti, Kuuliala, Antti, Penttilä, Anne, Kaukonen, Kirsi-Maija, Mustonen, Harri, Pettilä, Ville, Puolakkainen, Pauli, Kylänpää, Leena, Kuuliala, Krista
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17.02.2020
• Subjects: Adult; Aged; Case-Control Studies; Cholangiopancreatography, Endoscopic Retrograde; Female; Flow Cytometry; HLA-DR Antigens - metabolism; Humans; leukocytes; Leukocytes - metabolism; Lipopolysaccharides - pharmacology; Male; Middle Aged; Monocytes - drug effects; Monocytes - metabolism; NF-kappa B - metabolism; Pancreatitis; Pancreatitis - blood; Pancreatitis - diagnostic imaging; Phosphorylation; sepsis; Sepsis - blood; Sepsis - etiology; Signal Transduction; STAT1 Transcription Factor - metabolism; STAT3 Transcription Factor - metabolism; Time Factors; Young Adult; leukocytes; flow cytometry; signal transduction; sepsis; Pancreatitis

Activation of intracellular signaling pathways in circulating leukocytes represents an early step in systemic immune-inflammatory response occurring e.g. in acute pancreatitis (AP) and sepsis. Previously, we found aberrations in the phosphorylation of leukocyte signaling proteins in patients with se...