Genetic Polymorphism of ACE (I/D) is Associated with Diabetic Nephropathy in Pakistani Subjects

• Published in: Pakistan journal of zoology Vol. 55; no. 4; p. 1537
• Main Authors: Din, Umara Amir ud, Khan, Waqas Ahmed, Shahzad, Khurrum, Ali, Basharat, Hussain, Misbah, Awan, Fazli Rabbi
• Format: Journal Article
• Language: English
• Published: Lahore Knowledge Bylanes 31.08.2023; The Zoological Society of Pakistan
• Subjects: Aldosterone; Analysis; Angiotensin; Antihypertensives; Blood pressure; Causes of; Cholesterol; Creatinine; Demographic aspects; Development and progression; Diabetes; Diabetes mellitus; Diabetes therapy; Diabetic nephropathies; Diabetics; Diagnosis; Disease; Electrolytes; Enzymes; Gene polymorphism; Genetic aspects; Genetic polymorphisms; Genotype & phenotype; Genotypes; Genotyping; Glucose; Health aspects; Hemodynamics; Homeostasis; Hypertension; Kidney diseases; Kidneys; Laboratories; Medical research; Medicine, Experimental; Metabolism; Morbidity; Nephropathy; Peptides; Peptidyl-dipeptidase A; Polymorphism; Proteins; Regression analysis; Renal function; Renin; Renin-angiotensin system; Risk; Statistical analysis; Urea; Uric acid; Vasoconstriction; Pakistan; Lahore Pakistan

ABSTRACT Diabetic nephropathy (DN), also known as diabetic kidney disease (DKD), is a leading cause of morbidity and mortality in diabetic patients. A major cause of DKD is high blood pressure (hypertension) which remains uncontrolled chronically. Renin angiotensin aldosterone system (RAAS) is a maj...