Variations of MicroRNAs in Human Placentas and Plasma From Preeclamptic Pregnancy

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 63; no. 6; pp. 1276 - 1284
• Main Authors: Xu, Peng, Zhao, Yangyu, Liu, Ming, Wang, Yongqing, Wang, Hao, Li, Yu-xia, Zhu, Xiaoming, Yao, Yuanqing, Wang, Haibin, Qiao, Jie, Ji, Lei, Wang, Yan-ling
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.06.2014
• Subjects: Adult; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blotting, Western; Cardiology. Vascular system; Cell Line; Cell Movement - genetics; Diseases of mother, fetus and pregnancy; Down-Regulation; Female; Gynecology. Andrology. Obstetrics; Humans; In Situ Hybridization; Medical sciences; MicroRNAs - genetics; Multigene Family; Oligonucleotide Array Sequence Analysis; Placenta - metabolism; Pre-Eclampsia - blood; Pre-Eclampsia - genetics; Pregnancy; Pregnancy. Fetus. Placenta; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Smad2 Protein - genetics; Smad2 Protein - metabolism; Transcriptome; Trophoblasts - cytology; Trophoblasts - metabolism; Up-Regulation; Human; Hypertension; microRNAs; Biological fluid; Pregnancy disorders; Fetal membrane; Variations; Cardiovascular disease; Pregnancy toxemia; Blood plasma; Pregnancy; Placenta; Preeclampsia; Female; miR-17-92; Circulatory system; Woman; plasma; placenta; preeclampsia

Preeclampsia is a major cause of maternal and fetal mortality and morbidity worldwide. The differential expression of several microRNAs (miRNAs) has been found in preeclamptic placentas. However, great conflict exists regarding this aspect, and detailed examinations have largely been lacking of miRN...