Variations of MicroRNAs in Human Placentas and Plasma From Preeclamptic Pregnancy
Preeclampsia is a major cause of maternal and fetal mortality and morbidity worldwide. The differential expression of several microRNAs (miRNAs) has been found in preeclamptic placentas. However, great conflict exists regarding this aspect, and detailed examinations have largely been lacking of miRN...
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| Published in | Hypertension (Dallas, Tex. 1979) Vol. 63; no. 6; pp. 1276 - 1284 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hagerstown, MD
Lippincott Williams & Wilkins
01.06.2014
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Preeclampsia is a major cause of maternal and fetal mortality and morbidity worldwide. The differential expression of several microRNAs (miRNAs) has been found in preeclamptic placentas. However, great conflict exists regarding this aspect, and detailed examinations have largely been lacking of miRNA profiles in different parts of the placenta and in maternal plasma of women with this disorder. In this study, a total of 9 downregulated miRNAs (miR-195, miR-223, miR-218, miR-17, miR-18a, miR-19b1, miR-92a1, miR-379, and miR-411) and 7 upregulated miRNAs (miR-210, miR-30a-3p, miR-518b, miR-524, miR-17-3p, miR-151, and miR-193b) were identified in severe preeclampsia (sPE) placentas when compared with normal pregnant controls. In addition, sampling position in the chorionic or basal plate of placenta led to evident variations in differential miRNAs of sPE placentas. In a prospective pregnant cohort, we found that the circulating levels of 3 members of miR-17-92 cluster (ie, miR-18a, miR-19b1, and miR-92a1) were significantly lower, whereas that of miR-210 was higher in sPE patients than those in normal controls at gestational weeks 15 to 18 and at term. The results of in situ hybridization revealed the localization of miR-18a, miR-92a1, and miR-210 in various subtypes of placental trophoblasts and endothelial cells. In human trophoblast cell line, HTR8/SVneo cells, miR-18a could promote trophoblast cell invasion via targeting and suppressing Smad2 expression. This study provides fundamental evidences for exploring the roles of miRNAs in the pathogenesis of preeclampsia. |
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| AbstractList | Preeclampsia is a major cause of maternal and fetal mortality and morbidity worldwide. The differential expression of several microRNAs (miRNAs) has been found in preeclamptic placentas. However, great conflict exists regarding this aspect, and detailed examinations have largely been lacking of miRNA profiles in different parts of the placenta and in maternal plasma of women with this disorder. In this study, a total of 9 downregulated miRNAs (miR-195, miR-223, miR-218, miR-17, miR-18a, miR-19b1, miR-92a1, miR-379, and miR-411) and 7 upregulated miRNAs (miR-210, miR-30a-3p, miR-518b, miR-524, miR-17-3p, miR-151, and miR-193b) were identified in severe preeclampsia (sPE) placentas when compared with normal pregnant controls. In addition, sampling position in the chorionic or basal plate of placenta led to evident variations in differential miRNAs of sPE placentas. In a prospective pregnant cohort, we found that the circulating levels of 3 members of miR-17-92 cluster (ie, miR-18a, miR-19b1, and miR-92a1) were significantly lower, whereas that of miR-210 was higher in sPE patients than those in normal controls at gestational weeks 15 to 18 and at term. The results of in situ hybridization revealed the localization of miR-18a, miR-92a1, and miR-210 in various subtypes of placental trophoblasts and endothelial cells. In human trophoblast cell line, HTR8/SVneo cells, miR-18a could promote trophoblast cell invasion via targeting and suppressing Smad2 expression. This study provides fundamental evidences for exploring the roles of miRNAs in the pathogenesis of preeclampsia. Preeclampsia is a major cause of maternal and fetal mortality and morbidity worldwide. The differential expression of several microRNAs (miRNAs) has been found in preeclamptic placentas. However, great conflict exists regarding this aspect, and detailed examinations have largely been lacking of miRNA profiles in different parts of the placenta and in maternal plasma of women with this disorder. In this study, a total of 9 downregulated miRNAs (miR-195, miR-223, miR-218, miR-17, miR-18a, miR-19b1, miR-92a1, miR-379, and miR-411) and 7 upregulated miRNAs (miR-210, miR-30a-3p, miR-518b, miR-524, miR-17-3p, miR-151, and miR-193b) were identified in severe preeclampsia (sPE) placentas when compared with normal pregnant controls. In addition, sampling position in the chorionic or basal plate of placenta led to evident variations in differential miRNAs of sPE placentas. In a prospective pregnant cohort, we found that the circulating levels of 3 members of miR-17-92 cluster (ie, miR-18a, miR-19b1, and miR-92a1) were significantly lower, whereas that of miR-210 was higher in sPE patients than those in normal controls at gestational weeks 15 to 18 and at term. The results of in situ hybridization revealed the localization of miR-18a, miR-92a1, and miR-210 in various subtypes of placental trophoblasts and endothelial cells. In human trophoblast cell line, HTR8/SVneo cells, miR-18a could promote trophoblast cell invasion via targeting and suppressing Smad2 expression. This study provides fundamental evidences for exploring the roles of miRNAs in the pathogenesis of preeclampsia.Preeclampsia is a major cause of maternal and fetal mortality and morbidity worldwide. The differential expression of several microRNAs (miRNAs) has been found in preeclamptic placentas. However, great conflict exists regarding this aspect, and detailed examinations have largely been lacking of miRNA profiles in different parts of the placenta and in maternal plasma of women with this disorder. In this study, a total of 9 downregulated miRNAs (miR-195, miR-223, miR-218, miR-17, miR-18a, miR-19b1, miR-92a1, miR-379, and miR-411) and 7 upregulated miRNAs (miR-210, miR-30a-3p, miR-518b, miR-524, miR-17-3p, miR-151, and miR-193b) were identified in severe preeclampsia (sPE) placentas when compared with normal pregnant controls. In addition, sampling position in the chorionic or basal plate of placenta led to evident variations in differential miRNAs of sPE placentas. In a prospective pregnant cohort, we found that the circulating levels of 3 members of miR-17-92 cluster (ie, miR-18a, miR-19b1, and miR-92a1) were significantly lower, whereas that of miR-210 was higher in sPE patients than those in normal controls at gestational weeks 15 to 18 and at term. The results of in situ hybridization revealed the localization of miR-18a, miR-92a1, and miR-210 in various subtypes of placental trophoblasts and endothelial cells. In human trophoblast cell line, HTR8/SVneo cells, miR-18a could promote trophoblast cell invasion via targeting and suppressing Smad2 expression. This study provides fundamental evidences for exploring the roles of miRNAs in the pathogenesis of preeclampsia. |
| Author | Li, Yu-xia Wang, Haibin Xu, Peng Liu, Ming Zhu, Xiaoming Wang, Yan-ling Qiao, Jie Ji, Lei Wang, Yongqing Yao, Yuanqing Zhao, Yangyu Wang, Hao |
| Author_xml | – sequence: 1 givenname: Peng surname: Xu fullname: Xu, Peng organization: From the State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China (P.X., M.L., Hao Wang, Y.L., Haibin Wang, L.J., Y.W.); Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China (Y.Z., Y.W., J.Q.); Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, Xi’an, China (X.Z., Y.Y.); and University of Chinese Academy of Sciences, Beijing, China (P.X., Hao Wang) – sequence: 2 givenname: Yangyu surname: Zhao fullname: Zhao, Yangyu organization: From the State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China (P.X., M.L., Hao Wang, Y.L., Haibin Wang, L.J., Y.W.); Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China (Y.Z., Y.W., J.Q.); Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, Xi’an, China (X.Z., Y.Y.); and University of Chinese Academy of Sciences, Beijing, China (P.X., Hao Wang) – sequence: 3 givenname: Ming surname: Liu fullname: Liu, Ming organization: From the State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China (P.X., M.L., Hao Wang, Y.L., Haibin Wang, L.J., Y.W.); Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China (Y.Z., Y.W., J.Q.); Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, Xi’an, China (X.Z., Y.Y.); and University of Chinese Academy of Sciences, Beijing, China (P.X., Hao Wang) – sequence: 4 givenname: Yongqing surname: Wang fullname: Wang, Yongqing organization: From the State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China (P.X., M.L., Hao Wang, Y.L., Haibin Wang, L.J., Y.W.); Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China (Y.Z., Y.W., J.Q.); Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, Xi’an, China (X.Z., Y.Y.); and University of Chinese Academy of Sciences, Beijing, China (P.X., Hao Wang) – sequence: 5 givenname: Hao surname: Wang fullname: Wang, Hao organization: From the State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China (P.X., M.L., Hao Wang, Y.L., Haibin Wang, L.J., Y.W.); Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China (Y.Z., Y.W., J.Q.); Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, Xi’an, China (X.Z., Y.Y.); and University of Chinese Academy of Sciences, Beijing, China (P.X., Hao Wang) – sequence: 6 givenname: Yu-xia surname: Li fullname: Li, Yu-xia organization: From the State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China (P.X., M.L., Hao Wang, Y.L., Haibin Wang, L.J., Y.W.); Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China (Y.Z., Y.W., J.Q.); Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, Xi’an, China (X.Z., Y.Y.); and University of Chinese Academy of Sciences, Beijing, China (P.X., Hao Wang) – sequence: 7 givenname: Xiaoming surname: Zhu fullname: Zhu, Xiaoming organization: From the State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China (P.X., M.L., Hao Wang, Y.L., Haibin Wang, L.J., Y.W.); Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China (Y.Z., Y.W., J.Q.); Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, Xi’an, China (X.Z., Y.Y.); and University of Chinese Academy of Sciences, Beijing, China (P.X., Hao Wang) – sequence: 8 givenname: Yuanqing surname: Yao fullname: Yao, Yuanqing organization: From the State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China (P.X., M.L., Hao Wang, Y.L., Haibin Wang, L.J., Y.W.); Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China (Y.Z., Y.W., J.Q.); Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, Xi’an, China (X.Z., Y.Y.); and University of Chinese Academy of Sciences, Beijing, China (P.X., Hao Wang) – sequence: 9 givenname: Haibin surname: Wang fullname: Wang, Haibin organization: From the State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China (P.X., M.L., Hao Wang, Y.L., Haibin Wang, L.J., Y.W.); Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China (Y.Z., Y.W., J.Q.); Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, Xi’an, China (X.Z., Y.Y.); and University of Chinese Academy of Sciences, Beijing, China (P.X., Hao Wang) – sequence: 10 givenname: Jie surname: Qiao fullname: Qiao, Jie organization: From the State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China (P.X., M.L., Hao Wang, Y.L., Haibin Wang, L.J., Y.W.); Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China (Y.Z., Y.W., J.Q.); Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, Xi’an, China (X.Z., Y.Y.); and University of Chinese Academy of Sciences, Beijing, China (P.X., Hao Wang) – sequence: 11 givenname: Lei surname: Ji fullname: Ji, Lei organization: From the State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China (P.X., M.L., Hao Wang, Y.L., Haibin Wang, L.J., Y.W.); Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China (Y.Z., Y.W., J.Q.); Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, Xi’an, China (X.Z., Y.Y.); and University of Chinese Academy of Sciences, Beijing, China (P.X., Hao Wang) – sequence: 12 givenname: Yan-ling surname: Wang fullname: Wang, Yan-ling organization: From the State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China (P.X., M.L., Hao Wang, Y.L., Haibin Wang, L.J., Y.W.); Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China (Y.Z., Y.W., J.Q.); Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, Xi’an, China (X.Z., Y.Y.); and University of Chinese Academy of Sciences, Beijing, China (P.X., Hao Wang) |
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| Issue | 6 |
| Keywords | Human Hypertension microRNAs Biological fluid Pregnancy disorders Fetal membrane Variations Cardiovascular disease Pregnancy toxemia Blood plasma Pregnancy Placenta Preeclampsia Female miR-17-92 Circulatory system Woman plasma placenta preeclampsia |
| Language | English |
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| PublicationTitle | Hypertension (Dallas, Tex. 1979) |
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| Publisher | Lippincott Williams & Wilkins |
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| Snippet | Preeclampsia is a major cause of maternal and fetal mortality and morbidity worldwide. The differential expression of several microRNAs (miRNAs) has been found... |
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| SubjectTerms | Adult Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blotting, Western Cardiology. Vascular system Cell Line Cell Movement - genetics Diseases of mother, fetus and pregnancy Down-Regulation Female Gynecology. Andrology. Obstetrics Humans In Situ Hybridization Medical sciences MicroRNAs - genetics Multigene Family Oligonucleotide Array Sequence Analysis Placenta - metabolism Pre-Eclampsia - blood Pre-Eclampsia - genetics Pregnancy Pregnancy. Fetus. Placenta Reverse Transcriptase Polymerase Chain Reaction RNA Interference Smad2 Protein - genetics Smad2 Protein - metabolism Transcriptome Trophoblasts - cytology Trophoblasts - metabolism Up-Regulation |
| Title | Variations of MicroRNAs in Human Placentas and Plasma From Preeclamptic Pregnancy |
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