Polymorphisms of DNA repair genes XRCC1 and LIG4 and idiopathic male infertility

• Published in: Systems biology in reproductive medicine Vol. 63; no. 6; pp. 382 - 390
• Main Authors: Ghasemi, Hadi, Khodadadi, Iraj, Fattahi, Amir, Moghimbeigi, Abbas, Tavilani, Heidar
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.11.2017
• Subjects: DNA ligase; DNA repair; gene polymorphism; male infertility; X-ray repair cross complementing protein 1; DNA ligase; X-ray repair cross complementing protein 1; gene polymorphism; DNA repair; male infertility

Sperm DNA damage is one of the associated factors of idiopathic male infertility and abnormal spermatogenesis. This study was conducted to assess possible association between risk of male infertility with X-ray repair cross complementing group 1 (XRCC1) Arg399Gln (G to A) and DNA ligase 4 (LIG4) Thr...