Intratumoral CD8+ T Lymphocytes as a Prognostic Factor of Survival in Endometrial Carcinoma

• Published in: Clinical cancer research Vol. 10; no. 13; pp. 4450 - 4456
• Main Authors: Kondratiev, Svetlana, Sabo, Edmond, Yakirevich, Evgeny, Lavie, Ofer, Resnick, Murray B.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.07.2004
• Subjects: Antineoplastic agents; Biological and medical sciences; Carcinoma, Endometrioid - blood; Carcinoma, Endometrioid - diagnosis; Carcinoma, Endometrioid - mortality; Carcinoma, Papillary - blood; Carcinoma, Papillary - diagnosis; Carcinoma, Papillary - mortality; CD8 Antigens - biosynthesis; CD8-Positive T-Lymphocytes - metabolism; Cell Survival; Cytoplasm - metabolism; Endometrial Neoplasms - blood; Endometrial Neoplasms - diagnosis; Endometrial Neoplasms - mortality; Female; Granzymes; Humans; Immunohistochemistry; Medical sciences; Multivariate Analysis; Pharmacology. Drug treatments; Prognosis; Risk Factors; Serine Endopeptidases - biosynthesis; T-Lymphocytes - metabolism; Time Factors; Treatment Outcome; Tumors; Prognosis; Survival; Endometrial carcinoma; T-Lymphocyte; Female genital diseases

Purpose: CTLs are a prominent immune component infiltrating many solid tumors. These cells are considered to be a manifestation of host-immune response to the tumor; however, their prognostic significance remains a subject of considerable debate. The objective of this study was to evaluate the distr...