Biodegradable scaffolds facilitate epiretinal transplantation of hiPSC-Derived retinal neurons in nonhuman primates

• Published in: Acta biomaterialia Vol. 134; pp. 289 - 301
• Main Authors: Luo, Ziming, Xian, Bikun, Li, Kang, Li, Kaijing, Yang, Runcai, Chen, Mengfei, Xu, Chaochao, Tang, Mingjun, Rong, Huifeng, Hu, Dongpeng, Ye, Meifang, Yang, Sijing, Lu, Shoutao, Zhang, Haijun, Ge, Jian
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 15.10.2021; Elsevier BV
• Subjects: Animal models; Axons; Biodegradability; Biodegradable materials; Biodegradable scaffold; Biodegradation; Cell migration; Cryopreservation; Cytology; Electric contacts; Excitability; Fluorescence; Green fluorescent protein; hiPSC; Human influences; Macaca mulatta; Monkeys; Neurons; Optic nerve; Optic neuropathy; Organoids; Pluripotency; Polylactide-co-glycolide; Primates; Protein seeding; Retina; Retinal ganglion cell; Retinal ganglion cells; Retinal sheet; Rhesus monkey; Scaffolds; Stem cells; Survival; Transplantation; Tumorigenesis; Visual perception; Rhesus monkey; Retinal sheet; Biodegradable scaffold; hiPSC; Retinal ganglion cell

Transplantation of stem cell-derived retinal neurons is a promising regenerative therapy for optic neuropathy. However, significant anatomic differences compromise its efficacy in large animal models. The present study describes the procedure and outcomes of human-induced pluripotent stem cell (hiPS...