White Matter Lesions May Aid in Differentiating Idiopathic Normal Pressure Hydrocephalus and Alzheimer's Disease

• Published in: Journal of Alzheimer's disease Vol. 85; no. 2; p. 851
• Main Authors: Kuroda, Takeshi, Honma, Motoyasu, Mori, Yukiko, Futamura, Akinori, Sugimoto, Azusa, Kasai, Hideyo, Yano, Satoshi, Hieda, Sotaro, Kasuga, Kensaku, Ikeuchi, Takeshi, Ono, Kenjiro
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2022
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - pathology; Amyloid beta-Peptides - cerebrospinal fluid; Biomarkers - cerebrospinal fluid; Diagnosis, Differential; Female; Humans; Hydrocephalus, Normal Pressure - cerebrospinal fluid; Hydrocephalus, Normal Pressure - pathology; Male; Middle Aged; Peptide Fragments - cerebrospinal fluid; tau Proteins - cerebrospinal fluid; White Matter - pathology; white matter; amyloid; hydrocephalus; Alzheimer disease; glymphatic system; cerebrospinal fluid

Idiopathic normal pressure hydrocephalus (iNPH) is often misdiagnosed as Alzheimer's disease (AD) due to overlapping pathophysiology and similar imaging characteristics, including ventricular enlargement and increased white matter lesions (WMLs). To compare the extent and distribution of WMLs d...