Glycorandomization: A promising diversification strategy for the drug development

• Published in: European journal of medicinal chemistry Vol. 213; p. 113156
• Main Authors: Goel, Bharat, Tripathi, Nancy, Mukherjee, Debaraj, Jain, Shreyans K.
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 05.03.2021
• Subjects: Biological Products - chemical synthesis; Biological Products - chemistry; Chemoselective ligation; Drug Development; Genetic engineering; Glycodiversification; Glycosides - chemistry; Glycosylation; Humans; Molecular Structure; Natural products; Neoglycorandomization; Nucleotidylyltransferases; Chemoselective ligation; Neoglycorandomization; Genetic engineering; Glycodiversification; Natural products; Nucleotidylyltransferases

Glycorandomization is a natural product derivatization strategy in which different sugar moieties are linked to the aglycone part of the naturally existing glycosides to create glycorandomized libraries. Sugars attached to the natural products are responsible for affecting their solubility, mechanis...