A novel conjunction of folate-targeted carbon nanotubes containing protohemin and oridonin-liposome loaded microbubbles for cancer chemo-sonodynamic therapy

• Published in: Journal of drug targeting Vol. 27; no. 10; pp. 1076 - 1083
• Main Authors: Wang, Chuan-Jin, Wang, Heng-Zhi, Li, Wei
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 26.11.2019
• Subjects: chemo-sonodynamic antitumor activity; Folate-targeted carbon nanotubes; liposome microbubbles; oridonin; protohemin; oridonin; liposome microbubbles; Folate-targeted carbon nanotubes; chemo-sonodynamic antitumor activity; protohemin

To facilitate targeting drug delivery and combined therapy, we constructed a novel drug carrier, in which oridonin-liposome containing microbubbles (LUMO) are covalently adhered to folic acid-conjugated multiwalled carbon nanotubes loaded with protohemin (FMTP) to form a novel conjugate (FMTP-LUMO)....