Comparison of common platelet receptors between the chacma baboon (Papio ursinus) and human for use in pre-clinical human-targeted anti-platelet studies

• Published in: Platelets (Edinburgh) Vol. 27; no. 4; pp. 322 - 332
• Main Author: Janse van Rensburg, Walter J.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 18.05.2016
• Subjects: Adenosine Diphosphate - pharmacology; Amino Acid Sequence; Amino Acid Substitution; Animals; Anti-platelet studies; Arachidonic Acid - pharmacology; Blood Platelets - drug effects; Blood Platelets - metabolism; chacma baboon; Drug Evaluation, Preclinical; Flow Cytometry; Humans; Male; Papio ursinus; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - pharmacology; Platelet Membrane Glycoproteins - chemistry; Platelet Membrane Glycoproteins - genetics; Platelet Membrane Glycoproteins - metabolism; platelet receptors; Receptors, Cell Surface - chemistry; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; Receptors, Purinergic P2 - chemistry; Receptors, Purinergic P2 - genetics; Receptors, Purinergic P2 - metabolism; Ristocetin - pharmacology; chacma baboon; platelet receptors; Anti-platelet studies

Anti-platelet agents play a central part in the treatment and prevention of acute thrombotic events. Discriminating animal models are needed for the development of novel agents. The chacma baboon has been extensively used as a model to evaluate anti-platelet agents. However, limited data exist to pr...