A proteome-wide screen identifies the calcium binding proteins, S100A8/S100A9, as clinically relevant therapeutic targets in aortic dissection

• Published in: Pharmacological research Vol. 199; p. 107029
• Main Authors: Jiang, Hui, Zhao, Yaping, Su, Meiming, Sun, Lu, Chen, Meijie, Zhang, Zhidan, Ilyas, Iqra, Wang, Zhihua, Little, Peter J., Wang, Li, Weng, Jianping, Ge, Jianjun, Xu, Suowen
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier 01.01.2024
• Subjects: Aortic dissection; Pharmacotherapy; S100A8; S100A9; Pharmacotherapy; Aortic dissection; S100A9; S100A8

Aortic dissection (AD) is a fatal cardiovascular disease with limited pharmacotherapies. To discover novel therapeutic targets for AD, the present study was conducted on ascending aorta samples from AD patients versus those from control subjects using proteomic analysis. Integrated proteomic data an...