Autoantibodies to nuclear valosin-containing protein-like protein: systemic sclerosis-specific antibodies revealed by in vitro human proteome

• Published in: Rheumatology (Oxford, England) Vol. 63; no. 10; pp. 2865 - 2873
• Main Authors: Matsuda, Kazuki M, Kotani, Hirohito, Yamaguchi, Kei, Ono, Chihiro, Okumura, Taishi, Ogawa, Koji, Miya, Ayako, Sato, Ayaka, Uchino, Rikako, Yumi, Murakami, Matsunaka, Hiroshi, Kono, Masanori, Norimatsu, Yuta, Hisamoto, Teruyoshi, Kawanabe, Ruriko, Kuzumi, Ai, Fukasawa, Takemichi, Yoshizaki-Ogawa, Asako, Okamura, Tomohisa, Shoda, Hirofumi, Fujio, Keishi, Matsushita, Takashi, Goshima, Naoki, Sato, Shinichi, Yoshizaki, Ayumi
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.10.2024
• Subjects: Adult; Aged; Antibodies, Antinuclear - blood; Antibodies, Antinuclear - immunology; Antigens, Nuclear - immunology; Autoantibodies - blood; Autoantibodies - immunology; Female; Humans; Male; Middle Aged; Proteome - immunology; Retrospective Studies; Scleroderma, Systemic - blood; Scleroderma, Systemic - immunology; Valosin Containing Protein - immunology; autoantibody; protein array; systemic sclerosis; autoimmunity; proteome

Objectives To identify and characterize undescribed systemic sclerosis (SSc)-specific autoantibodies targeting nucleolar antigens and to assess their clinical significance. Methods We conducted proteome-wide autoantibody screening (PWAS) against serum samples from SSc patients with nucleolar pattern...