An alphacoronavirus polymerase structure reveals conserved replication factor functions

• Published in: Nucleic acids research Vol. 52; no. 10; pp. 5975 - 5986
• Main Authors: Anderson, Thomas K, Hoferle, Peter J, Chojnacki, Kennan J, Lee, Kenneth W, Coon, Joshua J, Kirchdoerfer, Robert N
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 10.06.2024
• Subjects: Animals; Coronavirus RNA-Dependent RNA Polymerase - chemistry; Coronavirus RNA-Dependent RNA Polymerase - genetics; Coronavirus RNA-Dependent RNA Polymerase - metabolism; Cryoelectron Microscopy; Models, Molecular; Porcine epidemic diarrhea virus - enzymology; Porcine epidemic diarrhea virus - genetics; Protein Structure, Tertiary; RNA and RNA-protein complexes; RNA, Viral - chemistry; RNA, Viral - genetics; RNA, Viral - metabolism; SARS-CoV-2 - enzymology; SARS-CoV-2 - genetics; Virus Replication - genetics

Coronaviruses are a diverse subfamily of viruses containing pathogens of humans and animals. This subfamily of viruses replicates their RNA genomes using a core polymerase complex composed of viral non-structural proteins: nsp7, nsp8 and nsp12. Most of our understanding of coronavirus molecular biol...