Low-dose transdermal scopolamine decreases blood pressure in mild essential hypertension

• Published in: Journal of hypertension Vol. 16; no. 3; p. 321
• Main Authors: Vesalainen, R K, Kaila, T J, Kantola, I M, Tahvanainen, K U, Juhani Airaksinen, K E, Kuusela, T A, Eckberg, D L
• Format: Journal Article
• Language: English
• Published: England 01.03.1998
• Subjects: Administration, Cutaneous; Adult; Baroreflex - drug effects; Baroreflex - physiology; Blood Pressure - drug effects; Blood Pressure - physiology; Cross-Over Studies; Double-Blind Method; Female; Heart Rate - drug effects; Heart Rate - physiology; Humans; Hypertension - drug therapy; Hypertension - physiopathology; Male; Middle Aged; Parasympathetic Nervous System - drug effects; Parasympathetic Nervous System - physiopathology; Parasympatholytics - administration & dosage; Parasympatholytics - adverse effects; Parasympatholytics - blood; Scopolamine - administration & dosage; Scopolamine - adverse effects; Scopolamine - blood; Sinoatrial Node - drug effects; Sinoatrial Node - physiopathology; Tidal Volume - drug effects; Vagus Nerve - drug effects; Vagus Nerve - physiopathology; Non-programmatic

Increasing cardiovascular parasympathetic nervous activity could have antihypertensive effects. Low-dose transdermal scopolamine increases vagal-cardiac modulation of sinus node and baroreflex sensitivity in healthy subjects and in cardiac patients. To study the short-term effects of transdermal sco...