Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

• Published in: Acta neuropathologica Vol. 117; no. 6; pp. 613 - 634
• Main Authors: Beach, Thomas G., Adler, Charles H., Lue, LihFen, Sue, Lucia I., Bachalakuri, Jyothi, Henry-Watson, Jonette, Sasse, Jeanne, Boyer, Sarah, Shirohi, Scophil, Brooks, Reed, Eschbacher, Jennifer, White, Charles L., Akiyama, Haru, Caviness, John, Shill, Holly A., Connor, Donald J., Sabbagh, Marwan N., Walker, Douglas G.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.06.2009; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Aging; alpha-Synuclein - metabolism; Alzheimer Disease - physiopathology; Alzheimer's disease; Apolipoproteins E - genetics; Brain - pathology; Brain - physiopathology; Brain research; Cognition Disorders - complications; Cognition Disorders - pathology; Cognition Disorders - physiopathology; Cognitive ability; Dementia; Diagnosis, Differential; Female; Humans; Immunohistochemistry; Lewy Body Disease - complications; Lewy Body Disease - pathology; Lewy Body Disease - physiopathology; Male; Medical research; Medicine; Medicine & Public Health; Movement Disorders - complications; Movement Disorders - pathology; Movement Disorders - physiopathology; Nerve Degeneration - pathology; Neurodegenerative Diseases - complications; Neurodegenerative Diseases - pathology; Neurodegenerative Diseases - physiopathology; Neurosciences; Original Paper; Parkinson Disease - physiopathology; Parkinson's disease; Pathology; Severity of Illness Index; United States > US; Arizona; Parkinsonism; Alzheimer’s disease; Limbic; Brainstem; Olfactory bulb; Neocortex; Parkinson’s disease; Incidental Lewy bodies; α-synuclein; Amgydala; Dementia with Lewy bodies

The two current major staging systems in use for Lewy body disorders fail to classify up to 50% of subjects. Both systems do not allow for large numbers of subjects who have Lewy-type α-synucleinopathy (LTS) confined to the olfactory bulb or who pass through a limbic-predominant pathway that at leas...