Coadministration of lopinavir/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 induction - Lim, Michael L; Min, Sherene S; Eron, Joseph J; Bertz, Richard J; Robinson, Marjorie; Gaedigk, Andrea; Kashuba, Angela D M (Journal of acquired immune deficiency syndromes (1999), 2004)
Keywords: Adult; Anticonvulsants - administration & dosage; Anticonvulsants - adverse effects; Anticonvulsants - pharmacokinetics; Cytochrome P-450 Enzyme System - biosynthesis; Cytochrome P-450 Enzyme System - genetics; Drug Interactions; Female; HIV Infections - complications; HIV Infections - drug therapy; HIV Protease Inhibitors - administration & dosage; HIV Protease Inhibitors - adverse effects; HIV Protease Inhibitors - pharmacokinetics; Humans; Lopinavir; Male; Pharmacogenetics; Phenytoin - administration & dosage; Phenytoin - adverse effects; Phenytoin - pharmacokinetics; Pyrimidinones - administration & dosage; Pyrimidinones - adverse effects; Pyrimidinones - pharmacokinetics; Ritonavir - administration & dosage; Ritonavir - adverse effects; Ritonavir - pharmacokinetics; Seizures - complications; Seizures - drug therapy