4D‐Printed Soft and Stretchable Self‐Folding Cuff Electrodes for Small‐Nerve Interfacing
Peripheral nerve interfacing (PNI) has a high clinical potential for treating various diseases, such as obesity or diabetes. However, currently existing electrodes present challenges to the interfacing procedure, which limit their clinical application, in particular, when targeting small peripheral...
Saved in:
Published in | Advanced materials (Weinheim) Vol. 35; no. 12; pp. e2210206 - n/a |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Germany
Wiley Subscription Services, Inc
01.03.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Peripheral nerve interfacing (PNI) has a high clinical potential for treating various diseases, such as obesity or diabetes. However, currently existing electrodes present challenges to the interfacing procedure, which limit their clinical application, in particular, when targeting small peripheral nerves (<200 µm). To improve the electrode handling and implantation, a nerve interface that can fold itself to a cuff around a small nerve, triggered by the body moisture during insertion, is fabricated. This folding is achieved by printing a bilayer of a flexible polyurethane printing resin and a highly swelling sodium acrylate hydrogel using photopolymerization. When immersed in an aqueous liquid, the hydrogel swells and folds the electrode softly around the nerve. Furthermore, the electrodes are robust, can be stretched (>20%), and bent to facilitate the implantation due to the use of soft and stretchable printing resins as substrates and a microcracked gold film as conductive layer. The straightforward implantation and extraction of the electrode as well as stimulation and recording capabilities on a small peripheral nerve in vivo are demonstrated. It is believed that such simple and robust to use self‐folding electrodes will pave the way for bringing PNI to a broader clinical application.
An electric peripheral nerve interface that can fold itself to a cuff around small nerves during the implantation is presented. This actuation property, combined with the use of stretchable materials, makes the device robust and straightforward to use. The stimulation and recording capabilities are shown on small nerves in vivo. |
---|---|
AbstractList | Abstract Peripheral nerve interfacing (PNI) has a high clinical potential for treating various diseases, such as obesity or diabetes. However, currently existing electrodes present challenges to the interfacing procedure, which limit their clinical application, in particular, when targeting small peripheral nerves (<200 µm). To improve the electrode handling and implantation, a nerve interface that can fold itself to a cuff around a small nerve, triggered by the body moisture during insertion, is fabricated. This folding is achieved by printing a bilayer of a flexible polyurethane printing resin and a highly swelling sodium acrylate hydrogel using photopolymerization. When immersed in an aqueous liquid, the hydrogel swells and folds the electrode softly around the nerve. Furthermore, the electrodes are robust, can be stretched (>20%), and bent to facilitate the implantation due to the use of soft and stretchable printing resins as substrates and a microcracked gold film as conductive layer. The straightforward implantation and extraction of the electrode as well as stimulation and recording capabilities on a small peripheral nerve in vivo are demonstrated. It is believed that such simple and robust to use self‐folding electrodes will pave the way for bringing PNI to a broader clinical application. Peripheral nerve interfacing (PNI) has a high clinical potential for treating various diseases, such as obesity or diabetes. However, currently existing electrodes present challenges to the interfacing procedure, which limit their clinical application, in particular, when targeting small peripheral nerves (<200 µm). To improve the electrode handling and implantation, a nerve interface that can fold itself to a cuff around a small nerve, triggered by the body moisture during insertion, is fabricated. This folding is achieved by printing a bilayer of a flexible polyurethane printing resin and a highly swelling sodium acrylate hydrogel using photopolymerization. When immersed in an aqueous liquid, the hydrogel swells and folds the electrode softly around the nerve. Furthermore, the electrodes are robust, can be stretched (>20%), and bent to facilitate the implantation due to the use of soft and stretchable printing resins as substrates and a microcracked gold film as conductive layer. The straightforward implantation and extraction of the electrode as well as stimulation and recording capabilities on a small peripheral nerve in vivo are demonstrated. It is believed that such simple and robust to use self-folding electrodes will pave the way for bringing PNI to a broader clinical application. Peripheral nerve interfacing (PNI) has a high clinical potential for treating various diseases, such as obesity or diabetes. However, currently existing electrodes present challenges to the interfacing procedure, which limit their clinical application, in particular, when targeting small peripheral nerves (<200 µm). To improve the electrode handling and implantation, a nerve interface that can fold itself to a cuff around a small nerve, triggered by the body moisture during insertion, is fabricated. This folding is achieved by printing a bilayer of a flexible polyurethane printing resin and a highly swelling sodium acrylate hydrogel using photopolymerization. When immersed in an aqueous liquid, the hydrogel swells and folds the electrode softly around the nerve. Furthermore, the electrodes are robust, can be stretched (>20%), and bent to facilitate the implantation due to the use of soft and stretchable printing resins as substrates and a microcracked gold film as conductive layer. The straightforward implantation and extraction of the electrode as well as stimulation and recording capabilities on a small peripheral nerve in vivo are demonstrated. It is believed that such simple and robust to use self‐folding electrodes will pave the way for bringing PNI to a broader clinical application. Peripheral nerve interfacing (PNI) has a high clinical potential for treating various diseases, such as obesity or diabetes. However, currently existing electrodes present challenges to the interfacing procedure, which limit their clinical application, in particular, when targeting small peripheral nerves (<200 µm). To improve the electrode handling and implantation, a nerve interface that can fold itself to a cuff around a small nerve, triggered by the body moisture during insertion, is fabricated. This folding is achieved by printing a bilayer of a flexible polyurethane printing resin and a highly swelling sodium acrylate hydrogel using photopolymerization. When immersed in an aqueous liquid, the hydrogel swells and folds the electrode softly around the nerve. Furthermore, the electrodes are robust, can be stretched (>20%), and bent to facilitate the implantation due to the use of soft and stretchable printing resins as substrates and a microcracked gold film as conductive layer. The straightforward implantation and extraction of the electrode as well as stimulation and recording capabilities on a small peripheral nerve in vivo are demonstrated. It is believed that such simple and robust to use self‐folding electrodes will pave the way for bringing PNI to a broader clinical application. An electric peripheral nerve interface that can fold itself to a cuff around small nerves during the implantation is presented. This actuation property, combined with the use of stretchable materials, makes the device robust and straightforward to use. The stimulation and recording capabilities are shown on small nerves in vivo. |
Author | Zurita, Francisco Hiendlmeier, Lukas Vogel, Jonas Kopic, Inola Al Boustani, George Del Duca, Fulvia Peng, Hu Nikić, Marta F. Teshima, Tetsuhiko Wolfrum, Bernhard |
Author_xml | – sequence: 1 givenname: Lukas orcidid: 0000-0003-0219-6871 surname: Hiendlmeier fullname: Hiendlmeier, Lukas organization: NTT Research Incorporated – sequence: 2 givenname: Francisco orcidid: 0000-0002-6166-499X surname: Zurita fullname: Zurita, Francisco organization: NTT Research Incorporated – sequence: 3 givenname: Jonas orcidid: 0000-0002-4693-2554 surname: Vogel fullname: Vogel, Jonas organization: Technical University of Munich – sequence: 4 givenname: Fulvia orcidid: 0000-0002-6684-173X surname: Del Duca fullname: Del Duca, Fulvia organization: NTT Research Incorporated – sequence: 5 givenname: George orcidid: 0000-0003-2723-8011 surname: Al Boustani fullname: Al Boustani, George organization: NTT Research Incorporated – sequence: 6 givenname: Hu orcidid: 0000-0001-9432-1929 surname: Peng fullname: Peng, Hu organization: Technical University of Munich – sequence: 7 givenname: Inola orcidid: 0000-0002-4147-462X surname: Kopic fullname: Kopic, Inola organization: Technical University of Munich – sequence: 8 givenname: Marta orcidid: 0000-0002-4048-7306 surname: Nikić fullname: Nikić, Marta organization: Technical University of Munich – sequence: 9 givenname: Tetsuhiko orcidid: 0000-0002-9462-7167 surname: F. Teshima fullname: F. Teshima, Tetsuhiko organization: NTT Research Incorporated – sequence: 10 givenname: Bernhard orcidid: 0000-0003-4438-3755 surname: Wolfrum fullname: Wolfrum, Bernhard email: bernhard.wolfrum@tum.de organization: NTT Research Incorporated |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36594106$$D View this record in MEDLINE/PubMed |
BookMark | eNqF0D9P3DAYx3ELXQUHdO1YRWLpkuOxE9vxeDr-FAlapGNu5MSPS5ATg50UsfESeI19JTU6ekhdOtnDx19Zv30yG_yAhHyisKAA7FibXi8YMEaBgdghc8oZzUtQfEbmoAqeK1FWe2Q_xjsAUALELtkrBFclBTEnP8qT388v16EbRjTZ2tsx00O6jAHH9lY3DrM1OpvMmXemG35mq8na7NRhOwZvMGbWh2zda-eS-YbhF2YXqRWsbpM-JB-sdhE_vp0H5Obs9Gb1Nb_8fn6xWl7mbUkLkVegGquaEisjwBjOBFLZCI6Ca9MayYFykJSrBlFaxKKqCikrahO2UBQH5Msmex_8w4RxrPsutuicHtBPsWZSAC-VZDzRo3_onZ_CkD6XVKUE5bJgSS02qg0-xoC2vg9dr8NTTaF-Hb5-Hb7eDp8efH7LTk2PZsv_Lp2A2oDHzuHTf3L18uRq-R7_A2RvkpM |
CitedBy_id | crossref_primary_10_1021_acs_chemrev_3c00335 crossref_primary_10_2147_IJN_S418534 crossref_primary_10_1002_anbr_202300102 crossref_primary_10_1002_smll_202402214 crossref_primary_10_1038_s41563_024_01903_2 crossref_primary_10_1063_5_0189181 crossref_primary_10_1002_adhm_202400624 crossref_primary_10_1002_adma_202312263 crossref_primary_10_1002_adfm_202308613 crossref_primary_10_3390_gels10010008 crossref_primary_10_1002_aelm_202300308 crossref_primary_10_1038_s41563_024_01886_0 crossref_primary_10_1007_s12274_023_6092_1 crossref_primary_10_1002_adhm_202302896 crossref_primary_10_1002_aisy_202400055 crossref_primary_10_1002_adma_202212015 crossref_primary_10_1002_adma_202307686 crossref_primary_10_1002_adma_202402301 crossref_primary_10_1002_app_55445 crossref_primary_10_3390_mi15050594 crossref_primary_10_1002_adfm_202314575 crossref_primary_10_1039_D3NR05488H crossref_primary_10_1186_s40580_023_00389_z |
Cites_doi | 10.1038/s41551-018-0335-6 10.1002/advs.202104404 10.1146/annurev.bioeng.10.061807.160518 10.1021/la049501e 10.1016/j.tem.2015.09.008 10.1002/adma.201102378 10.1038/s41371-019-0244-5 10.1002/advs.202102945 10.1002/adfm.202200269 10.1002/admt.202000034 10.1021/acsapm.0c01071 10.1016/j.cobme.2022.100368 10.1038/s41551-019-0446-8 10.1126/sciadv.abg7833 10.1088/1741-2552/abc025 10.1126/sciadv.1602326 10.1007/s40122-021-00306-4 10.1002/adfm.202210353 10.1063/1.2201874 10.3390/s18124152 10.1021/acsanm.1c01590 10.1007/BF00219055 10.1109/ELNANO.2013.6552092 10.14814/phy2.12718 10.1007/s11906-018-0821-y 10.1088/1741-2552/abfebb 10.1002/adma.201503696 10.1016/j.bios.2010.05.010 10.1063/5.0021887 10.1038/s41551-020-00615-7 10.1109/NER.2013.6695915 10.1088/1741-2552/abcdbe 10.1038/s41551-021-00817-7 10.3389/fnins.2019.00911 10.1002/adfm.201910606 10.1038/nmat4544 10.1088/1741-2552/abf398 10.1038/s41598-022-13679-z 10.1002/adhm.202201627 10.1126/sciadv.aaw1066 10.1126/scirobotics.aau8892 10.1002/adfm.202208881 10.1111/cns.13209 10.1038/nn.3905 10.1002/mame.202200306 10.3390/mi12121522 10.1002/admt.202100240 10.1016/j.comppsych.2019.152156 10.1152/jappl.1997.83.1.317 10.1109/JMEMS.2018.2881908 10.1088/1741-2560/3/4/L02 10.1002/adfm.201703019 10.1038/s41598-019-46967-2 10.1186/1743-0003-7-17 10.1007/978-3-030-41854-0_5 10.1242/jeb.201.1.155 |
ContentType | Journal Article |
Copyright | 2023 The Authors. Advanced Materials published by Wiley‐VCH GmbH 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH. 2023. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
Copyright_xml | – notice: 2023 The Authors. Advanced Materials published by Wiley‐VCH GmbH – notice: 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH. – notice: 2023. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
DBID | 24P WIN CGR CUY CVF ECM EIF NPM AAYXX CITATION 7SR 8BQ 8FD JG9 7X8 |
DOI | 10.1002/adma.202210206 |
DatabaseName | Wiley-Blackwell Open Access Collection Wiley Online Library (Open Access Collection) Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Engineered Materials Abstracts METADEX Technology Research Database Materials Research Database MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Materials Research Database Engineered Materials Abstracts Technology Research Database METADEX MEDLINE - Academic |
DatabaseTitleList | CrossRef MEDLINE Materials Research Database |
Database_xml | – sequence: 1 dbid: 24P name: Wiley-Blackwell Open Access Collection url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Engineering |
EISSN | 1521-4095 |
EndPage | n/a |
ExternalDocumentID | 10_1002_adma_202210206 36594106 ADMA202210206 |
Genre | article Journal Article |
GrantInformation_xml | – fundername: Free State of Bavaria – fundername: Federal Ministry of Education and Research |
GroupedDBID | --- .3N .GA 05W 0R~ 10A 1L6 1OB 1OC 1ZS 23M 24P 33P 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52W 52X 53G 5GY 5VS 66C 6P2 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A03 AAESR AAEVG AAHHS AANLZ AAONW AAXRX AAZKR ABCQN ABCUV ABIJN ABJNI ABLJU ABPVW ACAHQ ACCFJ ACCZN ACGFS ACIWK ACPOU ACXBN ACXQS ADBBV ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFZJQ AHBTC AITYG AIURR AIWBW AJBDE AJXKR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ATUGU AUFTA AZBYB AZVAB BAFTC BDRZF BFHJK BHBCM BMNLL BMXJE BNHUX BROTX BRXPI BY8 CS3 D-E D-F DCZOG DPXWK DR1 DR2 DRFUL DRSTM EBS F00 F01 F04 F5P G-S G.N GNP GODZA H.T H.X HBH HGLYW HHY HHZ HZ~ IX1 J0M JPC KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LYRES MEWTI MK4 MRFUL MRSTM MSFUL MSSTM MXFUL MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG P2P P2W P2X P4D Q.N Q11 QB0 QRW R.K RNS ROL RWI RWM RX1 RYL SUPJJ TN5 UB1 UPT V2E W8V W99 WBKPD WFSAM WIB WIH WIK WIN WJL WOHZO WQJ WRC WXSBR WYISQ XG1 XPP XV2 YR2 ZZTAW ~02 ~IA ~WT .Y3 31~ 6TJ 8WZ A6W AASGY AAYOK ABEML ABTAH ACBWZ ACSCC AFFNX ASPBG AVWKF AZFZN CGR CUY CVF ECM EIF EJD FEDTE FOJGT HF~ HVGLF LW6 M6K NDZJH NPM PALCI RIWAO RJQFR SAMSI WTY ZY4 AAYXX CITATION 7SR 8BQ 8FD JG9 7X8 |
ID | FETCH-LOGICAL-c4136-809bf9b4e8d60dd526e17b65e65adcd7501507159bee7fee38837781f0ddf033 |
IEDL.DBID | 24P |
ISSN | 0935-9648 |
IngestDate | Fri Aug 16 00:17:51 EDT 2024 Thu Oct 10 19:39:32 EDT 2024 Wed Oct 16 15:30:17 EDT 2024 Sat Sep 28 08:15:12 EDT 2024 Sat Aug 24 00:51:33 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 12 |
Keywords | small nerves self-folding stretchable materials 4D printing cuff electrodes hydrogels nerve interfaces |
Language | English |
License | Attribution 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c4136-809bf9b4e8d60dd526e17b65e65adcd7501507159bee7fee38837781f0ddf033 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0003-0219-6871 0000-0002-4693-2554 0000-0003-2723-8011 0000-0002-6166-499X 0000-0001-9432-1929 0000-0002-4048-7306 0000-0002-4147-462X 0000-0002-9462-7167 0000-0003-4438-3755 0000-0002-6684-173X |
OpenAccessLink | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fadma.202210206 |
PMID | 36594106 |
PQID | 2789615732 |
PQPubID | 2045203 |
PageCount | 11 |
ParticipantIDs | proquest_miscellaneous_2760549725 proquest_journals_2789615732 crossref_primary_10_1002_adma_202210206 pubmed_primary_36594106 wiley_primary_10_1002_adma_202210206_ADMA202210206 |
PublicationCentury | 2000 |
PublicationDate | 2023-03-01 |
PublicationDateYYYYMMDD | 2023-03-01 |
PublicationDate_xml | – month: 03 year: 2023 text: 2023-03-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | Germany |
PublicationPlace_xml | – name: Germany – name: Weinheim |
PublicationTitle | Advanced materials (Weinheim) |
PublicationTitleAlternate | Adv Mater |
PublicationYear | 2023 |
Publisher | Wiley Subscription Services, Inc |
Publisher_xml | – name: Wiley Subscription Services, Inc |
References | 2004; 20 1997; 83 2017; 3 2019; 98 2019; 13 2020; 17 2022; 21 2020; 11 1995; 176 2020; 8 2020; 5 2020; 4 2010; 26 2019; 25 2019; 28 2011; 23 2022; 32 2022; 33 1998; 201 2010; 7 2021; 7 2019; 9 2021; 6 2019; 4 2019; 3 2021; 4 2021; 3 2015; 18 2019; 5 2019; 33 2017; 27 2006; 3 2008; 10 2014; 84 2018; 20 2016; 15 2016; 4 2015; 26 2018; 18 2021; 10 2015; 27 2021; 12 2020; 30 2020 2022; 6 2006; 88 2021; 18 2022; 9 2022; 12 2022; 11 2013 2022; 307 e_1_2_9_31_1 e_1_2_9_52_1 e_1_2_9_50_1 e_1_2_9_10_1 e_1_2_9_35_1 e_1_2_9_56_1 e_1_2_9_12_1 e_1_2_9_33_1 e_1_2_9_54_1 e_1_2_9_14_1 e_1_2_9_39_1 e_1_2_9_16_1 e_1_2_9_37_1 e_1_2_9_58_1 e_1_2_9_18_1 e_1_2_9_20_1 e_1_2_9_22_1 e_1_2_9_45_1 e_1_2_9_24_1 e_1_2_9_43_1 e_1_2_9_8_1 e_1_2_9_6_1 e_1_2_9_4_1 e_1_2_9_2_1 e_1_2_9_26_1 e_1_2_9_49_1 e_1_2_9_28_1 e_1_2_9_47_1 e_1_2_9_30_1 e_1_2_9_53_1 Varga M. (e_1_2_9_36_1) 2013 e_1_2_9_51_1 e_1_2_9_34_1 e_1_2_9_57_1 e_1_2_9_13_1 e_1_2_9_32_1 e_1_2_9_55_1 e_1_2_9_15_1 e_1_2_9_38_1 e_1_2_9_17_1 e_1_2_9_19_1 Otchy T. M. (e_1_2_9_11_1) 2020; 11 e_1_2_9_42_1 e_1_2_9_40_1 e_1_2_9_21_1 e_1_2_9_46_1 e_1_2_9_23_1 e_1_2_9_44_1 e_1_2_9_7_1 e_1_2_9_5_1 e_1_2_9_3_1 e_1_2_9_1_1 e_1_2_9_9_1 e_1_2_9_25_1 Tibbits S. (e_1_2_9_41_1) 2014; 84 e_1_2_9_27_1 e_1_2_9_48_1 e_1_2_9_29_1 |
References_xml | – volume: 27 year: 2017 publication-title: Adv. Funct. Mater. – volume: 27 start-page: 6797 year: 2015 publication-title: Adv. Mater. – volume: 20 start-page: 24 year: 2018 publication-title: Curr. Hypertens. Rep. – volume: 28 start-page: 36 year: 2019 publication-title: J. Microelectromech. Syst. – volume: 33 year: 2022 publication-title: Adv. Funct. Mater. – volume: 307 year: 2022 publication-title: Macromol. Mater. Eng. – volume: 32 year: 2022 publication-title: Adv. Funct. Mater. – volume: 10 start-page: 985 year: 2021 publication-title: Pain Ther. – volume: 18 start-page: 310 year: 2015 publication-title: Nat. Neurosci. – volume: 23 start-page: H268 year: 2011 publication-title: Adv. Mater. – volume: 33 start-page: 716 year: 2019 publication-title: J. Hum. Hypertens. – volume: 3 start-page: L23 year: 2006 publication-title: J. Neural Eng. – volume: 4 start-page: 181 year: 2020 publication-title: Nat. Biomed. Eng. – volume: 98 year: 2019 publication-title: Compr. Psychiatry – volume: 18 year: 2021 publication-title: J. Neural Eng. – volume: 20 year: 2004 publication-title: Langmuir – volume: 4 year: 2016 publication-title: Physiol. Rep. – volume: 12 year: 2022 publication-title: Sci. Rep. – volume: 30 year: 2020 publication-title: Adv. Funct. Mater. – volume: 4 year: 2019 publication-title: Sci. Rob. – start-page: 237 year: 2013 end-page: 240 – volume: 25 start-page: 1222 year: 2019 publication-title: CNS Neurosci. Ther. – volume: 10 start-page: 275 year: 2008 publication-title: Annu. Rev. Biomed. Eng. – volume: 3 year: 2017 publication-title: Sci. Adv. – volume: 17 year: 2020 publication-title: J. Neural Eng. – volume: 4 start-page: 8376 year: 2021 publication-title: ACS Appl. Nano Mater. – volume: 15 start-page: 413 year: 2016 publication-title: Nat. Mater. – volume: 7 start-page: 17 year: 2010 publication-title: J. NeuroEng. Rehab. – volume: 4 start-page: 1010 year: 2020 publication-title: Nat. Biomed. Eng. – start-page: 235 year: 2013 end-page: 238 – volume: 18 start-page: 4152 year: 2018 publication-title: Sensors – volume: 176 start-page: 289 year: 1995 publication-title: J. Comp. Physiol. – volume: 26 start-page: 657 year: 2015 publication-title: Trends Endocrinol. Metab. – volume: 5 year: 2020 publication-title: Adv. Mater. Technol. – volume: 9 year: 2019 publication-title: Sci. Rep. – volume: 21 year: 2022 publication-title: Curr. Opin. Biomed. Eng. – volume: 9 year: 2022 publication-title: Adv. Sci. – volume: 12 start-page: 1522 year: 2021 publication-title: Micromachines – volume: 3 start-page: 58 year: 2019 publication-title: Nat. Biomed. Eng. – volume: 6 year: 2021 publication-title: Adv. Mater. Technol. – start-page: 95 year: 2020 end-page: 121 – volume: 26 start-page: 62 year: 2010 publication-title: Biosens. Bioelectron. – volume: 13 start-page: 911 year: 2019 publication-title: Front. Neurosci. – volume: 11 start-page: 4191 year: 2020 publication-title: React. Fission Nat., C. R. Reun. Com. Tech. – volume: 8 year: 2020 publication-title: APL Mater. – volume: 201 start-page: 155 year: 1998 publication-title: J. Exp. Biol. – volume: 7 year: 2021 publication-title: Sci. Adv. – volume: 83 start-page: 317 year: 1997 publication-title: J. Appl. Physiol. – volume: 88 year: 2006 publication-title: Appl. Phys. Lett. – volume: 5 year: 2019 publication-title: Sci. Adv. – volume: 6 start-page: 741 year: 2022 publication-title: Nat. Biomed. Eng. – volume: 11 year: 2022 publication-title: Adv. Healthcare Mater. – volume: 3 start-page: 243 year: 2021 publication-title: ACS Appl. Polym. Mater. – volume: 84 start-page: 116 year: 2014 publication-title: Archit. Des. – ident: e_1_2_9_18_1 doi: 10.1038/s41551-018-0335-6 – ident: e_1_2_9_32_1 doi: 10.1002/advs.202104404 – ident: e_1_2_9_48_1 doi: 10.1146/annurev.bioeng.10.061807.160518 – ident: e_1_2_9_56_1 doi: 10.1021/la049501e – ident: e_1_2_9_7_1 doi: 10.1016/j.tem.2015.09.008 – ident: e_1_2_9_21_1 doi: 10.1002/adma.201102378 – ident: e_1_2_9_8_1 doi: 10.1038/s41371-019-0244-5 – ident: e_1_2_9_10_1 doi: 10.1002/advs.202102945 – ident: e_1_2_9_27_1 doi: 10.1002/adfm.202200269 – ident: e_1_2_9_39_1 doi: 10.1002/admt.202000034 – ident: e_1_2_9_55_1 doi: 10.1021/acsapm.0c01071 – ident: e_1_2_9_3_1 doi: 10.1016/j.cobme.2022.100368 – ident: e_1_2_9_13_1 doi: 10.1038/s41551-019-0446-8 – ident: e_1_2_9_33_1 doi: 10.1126/sciadv.abg7833 – ident: e_1_2_9_15_1 doi: 10.1088/1741-2552/abc025 – ident: e_1_2_9_57_1 doi: 10.1126/sciadv.1602326 – ident: e_1_2_9_6_1 doi: 10.1007/s40122-021-00306-4 – ident: e_1_2_9_43_1 doi: 10.1002/adfm.202210353 – ident: e_1_2_9_46_1 doi: 10.1063/1.2201874 – ident: e_1_2_9_47_1 doi: 10.3390/s18124152 – ident: e_1_2_9_45_1 doi: 10.1021/acsanm.1c01590 – ident: e_1_2_9_51_1 doi: 10.1007/BF00219055 – start-page: 237 volume-title: 2013 IEEE XXXIII Int. Scientific Conf. Electronics and Nanotechnology (ELNANO) year: 2013 ident: e_1_2_9_36_1 doi: 10.1109/ELNANO.2013.6552092 contributor: fullname: Varga M. – ident: e_1_2_9_9_1 doi: 10.14814/phy2.12718 – ident: e_1_2_9_5_1 doi: 10.1007/s11906-018-0821-y – volume: 11 start-page: 4191 year: 2020 ident: e_1_2_9_11_1 publication-title: React. Fission Nat., C. R. Reun. Com. Tech. contributor: fullname: Otchy T. M. – ident: e_1_2_9_17_1 doi: 10.1088/1741-2552/abfebb – ident: e_1_2_9_37_1 doi: 10.1002/adma.201503696 – ident: e_1_2_9_12_1 doi: 10.1016/j.bios.2010.05.010 – ident: e_1_2_9_16_1 doi: 10.1063/5.0021887 – ident: e_1_2_9_19_1 doi: 10.1038/s41551-020-00615-7 – ident: e_1_2_9_53_1 doi: 10.1109/NER.2013.6695915 – ident: e_1_2_9_23_1 doi: 10.1088/1741-2552/abcdbe – ident: e_1_2_9_24_1 doi: 10.1038/s41551-021-00817-7 – volume: 84 start-page: 116 year: 2014 ident: e_1_2_9_41_1 publication-title: Archit. Des. contributor: fullname: Tibbits S. – ident: e_1_2_9_26_1 doi: 10.3389/fnins.2019.00911 – ident: e_1_2_9_38_1 doi: 10.1002/adfm.201910606 – ident: e_1_2_9_42_1 doi: 10.1038/nmat4544 – ident: e_1_2_9_31_1 doi: 10.1088/1741-2552/abf398 – ident: e_1_2_9_58_1 doi: 10.1038/s41598-022-13679-z – ident: e_1_2_9_29_1 doi: 10.1002/adhm.202201627 – ident: e_1_2_9_35_1 doi: 10.1126/sciadv.aaw1066 – ident: e_1_2_9_4_1 doi: 10.1126/scirobotics.aau8892 – ident: e_1_2_9_50_1 doi: 10.1002/adfm.202208881 – ident: e_1_2_9_2_1 doi: 10.1111/cns.13209 – ident: e_1_2_9_22_1 doi: 10.1038/nn.3905 – ident: e_1_2_9_44_1 doi: 10.1002/mame.202200306 – ident: e_1_2_9_30_1 doi: 10.3390/mi12121522 – ident: e_1_2_9_40_1 doi: 10.1002/admt.202100240 – ident: e_1_2_9_1_1 doi: 10.1016/j.comppsych.2019.152156 – ident: e_1_2_9_28_1 doi: 10.1152/jappl.1997.83.1.317 – ident: e_1_2_9_25_1 doi: 10.1109/JMEMS.2018.2881908 – ident: e_1_2_9_34_1 doi: 10.1088/1741-2560/3/4/L02 – ident: e_1_2_9_49_1 doi: 10.1002/adfm.201703019 – ident: e_1_2_9_20_1 doi: 10.1038/s41598-019-46967-2 – ident: e_1_2_9_52_1 doi: 10.1186/1743-0003-7-17 – ident: e_1_2_9_14_1 doi: 10.1007/978-3-030-41854-0_5 – ident: e_1_2_9_54_1 doi: 10.1242/jeb.201.1.155 |
SSID | ssj0009606 |
Score | 2.5878167 |
Snippet | Peripheral nerve interfacing (PNI) has a high clinical potential for treating various diseases, such as obesity or diabetes. However, currently existing... Abstract Peripheral nerve interfacing (PNI) has a high clinical potential for treating various diseases, such as obesity or diabetes. However, currently... |
SourceID | proquest crossref pubmed wiley |
SourceType | Aggregation Database Index Database Publisher |
StartPage | e2210206 |
SubjectTerms | 4D printing cuff electrodes Electric Conductivity Electrodes Electrodes, Implanted Folding Hydrogels Implantation Materials science Moisture effects nerve interfaces Peripheral nerves Peripheral Nerves - physiology Photopolymerization Polyurethane resins Printing Robustness self‐folding small nerves stretchable materials Substrates |
Title | 4D‐Printed Soft and Stretchable Self‐Folding Cuff Electrodes for Small‐Nerve Interfacing |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fadma.202210206 https://www.ncbi.nlm.nih.gov/pubmed/36594106 https://www.proquest.com/docview/2789615732 https://search.proquest.com/docview/2760549725 |
Volume | 35 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELYquMChojzapYBcqRKniMSxHfu4YneFKoFQl0qciOx4fNoGtI87P4Hf2F_SmWQ3y4oDEpcokcdJNDO2v_HjG8Z-xiLNsCBLAJ03kcpB4qy3aBAd06ryOgDNd1zf6Ks_8te9un91ir_lh-gm3KhlNP01NXDnZxdr0lAXGt4gQTELcW5vI7Yx5NdC3q5pd3WTXZNW-xKrpVnRNqbiYrP-5rD0BmtuQtdm7Bntsc9L0Mj7rZW_sE9Q77PdV1SCB-xBDv49v9xOif4h8DF2rtzVeDOfkl3ofBQfwySizKhdb-KXixj5sM2CE2DGEb3y8V83maDMDe2D5M1sYXQVSh-yu9Hw7vIqWeZOSCoclohj2PpovQQTdBqCEhqywmsFWrlQBcQJDRJU1gMUESA3GKkWJosoHNM8P2Jb9WMN3xiPBgx2a85U2kmTe2MLJ4scQgwKAVPeY-crzZVPLUNG2XIhi5J0XHY67rGTlWLLZUuZlXQSF1FVkYse-9EVo4_TwoWr4XFBMhh0SVsI1WNfW4N0n8q1sjKjl4vGQu_8Q9kfXPe7p-OPVPrOdijnfLsR7YRtzacLOEVkMvdnjfPhdfBb_Ac5p9yc |
link.rule.ids | 315,786,790,1382,11589,27955,27956,46085,46327,46509,46751 |
linkProvider | Wiley-Blackwell |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LTxsxELaq9NByqEopEF51JaSeVtmH7bWPUSBKWxIhJZU4sfKux6ewqfK48xP4jfwSZnaThYgDErddebxrzfjxzdj-hrFzn4YRFkQBYOcNhLQQWJMbNIjyYVHkygHFO4YjNfgn_tzIzWlCugtT80M0ATcaGdV8TQOcAtKdZ9ZQ6yrioJicFiLd_iiIDY7IncX1M--uqtJr0nZfYJTQG97GMO5s199el16BzW3sWi0-_a_syxo18m5t5l32AcpvbOcFl-AeuxUXj_cP13Pif3B8jLMrtyU-LOdkGLogxccw9SjTrzeceG_lPb-s0-A4WHCEr3x8Z6dTlBnRQUhehQu9LVD6O5v0Lye9QbBOnhAUuC4RybDJvckFaKdC52SsIEpzJUFJ6wqHQKGCgtLkAKkHSDS6qqmOPAr7MEn2WauclXDIuNegcV6zulBW6CTXJrUiTcB5JxExJW32a6O57H9NkZHVZMhxRjrOGh232clGsdl6qCwyuoqLsCpN4jb72RRjJ6edC1vCbEUy6HUJk8ayzQ5qgzS_SpQ0IqKPx5WF3mhD1r0Ydpu3o_dU-sE-DSbDq-zq9-jvMftMCejrU2knrLWcr-AUYcoyP6s64hPwSt8b |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT-MwELZWIK3ggHZZFsoW8EorcYqah-3Yx4pSsY9WldqVetrIicenElBp7_wEfiO_hJmkTak4rMQtkceJNTO2Pz_mG8Z--DSMsCAKAJ03ENJCYE1u0CDKh0WRKwe03zEYqpu_4tdUTl9F8df8EM2GG_WMarymDn7vfGdDGmpdxRsU05qFOLd3hUL4QNzOYrSh3VVVdk067QuMEnpN2xjGne3629PSG6y5DV2ruaf_iR2sQCPv1lb-zD5Aecj2X1EJfmH_RO_58Wk0J_oHx8c4uHJb4sNiTnah-Cg-hplHmX593sSvlt7z6zoLjoMHjuiVj2_tbIYyQ7oHyavdQm8LlD5ik_715OomWOVOCAqclohj2OTe5AK0U6FzMlYQpbmSoKR1hUOcUCFBaXKA1AMkGleqqY48CvswSb6ynfKuhBPGvQaNw5rVhbJCJ7k2qRVpAs47iYApabHLteay-5ohI6u5kOOMdJw1Om6x9lqx2aqnPGQUiYuoKk3iFvveFKOP08GFLeFuSTK46BImjWWLHdcGaX6VKGlERB-PKwv9pw1ZtzfoNm-n76l0wT6Oev3sz8_h729sj9LP13fS2mxnMV_CGYKURX5e-eELpKjeRA |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=4D-Printed+Soft+and+Stretchable+Self-Folding+Cuff+Electrodes+for+Small-Nerve+Interfacing&rft.jtitle=Advanced+materials+%28Weinheim%29&rft.au=Hiendlmeier%2C+Lukas&rft.au=Zurita%2C+Francisco&rft.au=Vogel%2C+Jonas&rft.au=Del+Duca%2C+Fulvia&rft.date=2023-03-01&rft.eissn=1521-4095&rft.volume=35&rft.issue=12&rft.spage=e2210206&rft_id=info:doi/10.1002%2Fadma.202210206&rft_id=info%3Apmid%2F36594106&rft.externalDocID=36594106 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0935-9648&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0935-9648&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0935-9648&client=summon |