Essential Hypertension Is Associated With Changes in Gut Microbial Metabolic Pathways: A Multisite Analysis of Ambulatory Blood Pressure

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 78; no. 3; pp. 804 - 815
• Main Authors: Nakai, Michael, Ribeiro, Rosilene V., Stevens, Bruce R., Gill, Paul, Muralitharan, Rikeish R., Yiallourou, Stephanie, Muir, Jane, Carrington, Melinda, Head, Geoffrey A., Kaye, David M., Marques, Francine Z.
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 01.09.2021
• Subjects: Aged; Blood Pressure - physiology; Blood Pressure Monitoring, Ambulatory; Case-Control Studies; Essential Hypertension - metabolism; Female; Gastrointestinal Microbiome - physiology; Humans; Male; Metabolic Networks and Pathways - physiology; Middle Aged; acetate; blood pressure; prevalence; machine learning; hypertension

Recent evidence supports a role for the gut microbiota in hypertension, but whether ambulatory blood pressure is associated with gut microbiota and their metabolites remains unclear. We characterized the function of the gut microbiota, their metabolites and receptors in untreated human hypertensive...