Interleukin-1α Is a Central Regulator of Leukocyte-Endothelial Adhesion in Myocardial Infarction and in Chronic Kidney Disease

• Published in: Circulation (New York, N.Y.) Vol. 144; no. 11; pp. 893 - 908
• Main Authors: Schunk, Stefan J., Triem, Sarah, Schmit, David, Zewinger, Stephen, Sarakpi, Tamim, Becker, Ellen, Hütter, Gregor, Wrublewsky, Selina, Küting, Fabienne, Hohl, Mathias, Alansary, Dalia, Prates Roma, Leticia, Lipp, Peter, Möllmann, Julia, Lehrke, Michael, Laschke, Matthias W., Menger, Michael D., Kramann, Rafael, Boor, Peter, Jahnen-Dechent, Willi, März, Winfried, Böhm, Michael, Laufs, Ulrich, Niemeyer, Barbara A., Fliser, Danilo, Ampofo, Emmanuel, Speer, Thimoteus
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 14.09.2021
• Subjects: Animals; Cell Adhesion - drug effects; Cell Adhesion - physiology; Endothelial Cells - metabolism; Endothelium - metabolism; Humans; Inflammation - drug therapy; Inflammation - metabolism; Interleukin-1alpha - metabolism; Interleukin-1alpha - pharmacology; Mice; Monocytes - metabolism; Myocardial Infarction - drug therapy; Myocardial Infarction - metabolism; Neutrophils - metabolism; Renal Insufficiency, Chronic - drug therapy; Renal Insufficiency, Chronic - metabolism; Vascular Cell Adhesion Molecule-1 - metabolism; chronic kidney disease; interleukin-1α; inflammation; leukocyte adhesion; myocardial infarction

Cardiovascular diseases and chronic kidney disease (CKD) are highly prevalent, aggravate each other, and account for substantial mortality. Both conditions are characterized by activation of the innate immune system. The alarmin interleukin-1α (IL-1α) is expressed in a variety of cell types promotin...