The divergent roles of sortase in the biology of Gram-positive bacteria

• Published in: Cell surface (Amsterdam) Vol. 7; p. 100055
• Main Authors: Susmitha, Aliyath, Bajaj, Harsha, Madhavan Nampoothiri, Kesavan
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2021; Elsevier
• Subjects: Cell wall; Gram-positive; Non-pathogenic; Pathogenic; Sortase; Non-pathogenic; Gram-positive; Pathogenic; Sortase; Cell wall

The bacterial cell wall contains numerous surface-exposed proteins, which are covalently anchored and assembled by a sortase family of transpeptidase enzymes. The sortase are cysteine transpeptidases that catalyzes the covalent attachment of surface protein to the cell wall peptidoglycan. Among the...