Signaling roles of platelets in skeletal muscle regeneration

• Published in: BioEssays Vol. 45; no. 12; pp. e2300134 - n/a
• Main Authors: Graca, Flavia A., Minden‐Birkenmaier, Benjamin A., Stephan, Anna, Demontis, Fabio, Labelle, Myriam
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2023
• Subjects: Adipose tissue; Angiogenesis; Blood Platelets - metabolism; Blood vessels; Cell proliferation; Cells (biology); Chemokines; Clotting; Cytokines - metabolism; Granular materials; Growth factors; Injury prevention; Leukocytes (neutrophilic); Metabolism; Metabolites; muscle repair; Muscle, Skeletal - physiology; Muscles; Musculoskeletal system; Myogenesis; neutrophils; platelet secretome; Platelets; platelet‐rich plasma; Regeneration (physiology); Satellite cells; Secretome; Signal Transduction; Skeletal muscle; skeletal muscle regeneration; Stromal cells; Tissue engineering; Wound Healing; angiogenesis; skeletal muscle regeneration; muscle repair; platelet secretome; neutrophils; platelet-rich plasma; platelets

Platelets have important hemostatic functions in repairing blood vessels upon tissue injury. Cytokines, growth factors, and metabolites stored in platelet α‐granules and dense granules are released upon platelet activation and clotting. Emerging evidence indicates that such platelet‐derived signalin...