Depression, sleep physiology, and antidepressant drugs

• Published in: Depression and anxiety Vol. 14; no. 1; pp. 19 - 28
• Main Authors: Winokur, Andrew, Gary, Keith A., Rodner, Shannon, Rae-Red, Carole, Fernando, Antonio T., Szuba, Martin P.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 2001
• Subjects: Antidepressive Agents - therapeutic use; Depressive Disorder - drug therapy; Depressive Disorder - physiopathology; Humans; hypersomnia; insomnia; Polysomnography; REM; Sleep - drug effects; Sleep - physiology; sleep stages

This review summarizes current findings regarding effects of antidepressant compounds on sleep architecture and interprets their clinical relevance. Effects of the major classes of antidepressant drugs on sleep properties are presented, with the antidepressant compounds organized into categories bas...