A neutralizing-protective supersite of human monoclonal antibodies for yellow fever virus

• Published in: Innovation (New York, NY) Vol. 3; no. 6; p. 100323
• Main Authors: Li, Yan, Chen, Zhihai, Wu, Lili, Dai, Lianpan, Qi, Jianxun, Chai, Yan, Li, Shihua, Wang, Qihui, Tong, Zhou, Ma, Sufang, Duan, Xiaomin, Ren, Shuning, Song, Rui, Liang, Mifang, Liu, Wenjun, Yan, Jinghua, Gao, George F.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 08.11.2022; Elsevier
• Subjects: complex structure; human monoclonal antibody; neutralizing antibody; prM-binding site; supersite; yellow fever virus; neutralizing antibody; yellow fever virus; complex structure; prM-binding site; supersite; human monoclonal antibody

The yellow fever virus (YFV) is a life-threatening human pathogen. Owing to the lack of available therapeutics, non-vaccinated individuals are at risk. Here, we isolated eight human monoclonal antibodies that neutralize YFV infection. Five recognized overlapping epitopes and exhibited potent neutral...