Circulating T helper and T regulatory subsets in untreated early rheumatoid arthritis and healthy control subjects

• Published in: Journal of leukocyte biology Vol. 100; no. 4; pp. 823 - 833
• Main Authors: Pandya, Jayesh M., Lundell, Anna‐Carin, Hallström, Magnus, Andersson, Kerstin, Nordström, Inger, Rudin, Anna
• Format: Journal Article
• Language: English
• Published: United States 01.10.2016
• Subjects: Adult; Aged; Aging - immunology; Antigens, Differentiation, T-Lymphocyte - analysis; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - immunology; autoimmunity; Case-Control Studies; Cell Biology; chemokine receptors; chronic inflammation; Clinical Medicine; collagen-induced arthritis; cytokine production; Cytokines - biosynthesis; Cytokines - genetics; Cytokines - secretion; disease; Disease Progression; distinct; Female; fibroblasts; Flow Cytometry - methods; gamma receptors; Gene Expression Profiling; Hematology; Humans; Immunophenotyping; Klinisk medicin; Lymphocyte Count; Male; Middle Aged; multivariate discriminant analysis; peripheral-blood; Receptors, CXCR3 - analysis; synovial-fluid; T cell profile; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - secretion; T-Lymphocytes, Helper-Inducer - immunology; T-Lymphocytes, Helper-Inducer - secretion; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - secretion; th1 cells; Transcription Factors - biosynthesis; Transcription Factors - genetics; chemokine receptors; T cell profile; autoimmunity; multivariate discriminant analysis

Blood T helper profile separates ueRA patients from controls by a skewed balance toward a CCR4+CXCR3− Th2 and Th17 phenotype in patients. The pathogenic role and frequency of T cell subtypes in early rheumatoid arthritis are still unclear. We therefore performed a comprehensive analysis of the circu...