Greater physical fitness (VO2max) in healthy older adults associated with increased integrity of the locus coeruleus–noradrenergic system

• Published in: Acta Physiologica Vol. 240; no. 8; pp. e14191 - n/a
• Main Authors: Plini, Emanuele R. G., Melnychuk, Michael C., Andrews, Ralph, Boyle, Rory, Whelan, Robert, Spence, Jeffrey S., Chapman, Sandra B., Robertson, Ian H., Dockree, Paul M.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.08.2024
• Subjects: Aged; aging; brain age; Catecholamines; Dementia disorders; Exercise - physiology; Female; Humans; Locus coeruleus; Locus Coeruleus - metabolism; Locus Coeruleus - physiology; locus Coeruleus; Vo2max; Magnetic Resonance Imaging; Male; Middle Aged; Morphometry; Neurodegeneration; neuroimaging; Neuromodulation; neuromodulators; Neuroprotection; Neurosciences; Norepinephrine; Norepinephrine - metabolism; Oxygen Consumption - physiology; Physical activity; Physical fitness; Physical Fitness - physiology; Up-regulation; voxel‐based morphometry; neuromodulators; brain age; voxel‐based morphometry; aging; locus Coeruleus; neuroimaging

Aim Physical activity (PA) is a key component for brain health and Reserve, and it is among the main dementia protective factors. However, the neurobiological mechanisms underpinning Reserve are not fully understood. In this regard, a noradrenergic (NA) theory of cognitive reserve (Robertson, 2013)...