Effect of Smoking on Blood Pressure and Resting Heart Rate: A Mendelian Randomization Meta-Analysis in the CARTA Consortium

• Published in: Circulation. Cardiovascular genetics Vol. 8; no. 6; pp. 832 - 841
• Main Authors: Linneberg, Allan, Jacobsen, Rikke K., Skaaby, Tea, Taylor, Amy E., Fluharty, Meg E., Jeppesen, Jørgen L., Bjorngaard, Johan H., Åsvold, Bjørn O., Gabrielsen, Maiken E., Campbell, Archie, Marioni, Riccardo E., Kumari, Meena, Marques-Vidal, Pedro, Kaakinen, Marika, Cavadino, Alana, Postmus, Iris, Ahluwalia, Tarunveer S., Wannamethee, S. Goya, Lahti, Jari, Räikkönen, Katri, Palotie, Aarno, Wong, Andrew, Dalgård, Christine, Ford, Ian, Ben-Shlomo, Yoav, Christiansen, Lene, Kyvik, Kirsten O., Kuh, Diana, Eriksson, Johan G., Whincup, Peter H., Mbarek, Hamdi, de Geus, Eco J.C., Vink, Jacqueline M., Boomsma, Dorret I., Smith, George Davey, Lawlor, Debbie A., Kisialiou, Aliaksei, McConnachie, Alex, Padmanabhan, Sandosh, Jukema, J. Wouter, Power, Chris, Hyppönen, Elina, Preisig, Martin, Waeber, Gerard, Vollenweider, Peter, Korhonen, Tellervo, Laatikainen, Tiina, Salomaa, Veikko, Kaprio, Jaakko, Kivimaki, Mika, Smith, Blair H., Hayward, Caroline, Sørensen, Thorkild I.A., Thuesen, Betina H., Sattar, Naveed, Morris, Richard W., Romundstad, Pål R., Munafò, Marcus R., Jarvelin, Marjo-Riitta, Husemoen, Lise Lotte N.
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.12.2015
• Subjects: Alleles; Blood Pressure - genetics; Female; Heart Rate - genetics; Humans; Hypertension - etiology; Hypertension - genetics; Hypertension - physiopathology; Male; Smoking - adverse effects; Smoking - genetics; Smoking - physiopathology; blood pressure; heart rate; Mendelian randomization; hypertension; smoking

BACKGROUND—Smoking is an important cardiovascular disease risk factor, but the mechanisms linking smoking to blood pressure are poorly understood. METHODS AND RESULTS—Data on 141 317 participants (62 666 never, 40 669 former, 37 982 current smokers) from 23 population-based studies were included in...