Insight into Nephrocan Function in Mouse Endoderm Patterning

• Published in: International journal of molecular sciences Vol. 21; no. 1; p. 8
• Main Authors: Addeo, Martina, Buonaiuto, Silvia, Guerriero, Ilaria, Amendola, Elena, Visconte, Feliciano, Marino, Antonio, De Angelis, Maria Teresa, Russo, Filomena, Roberto, Luca, Marotta, Pina, Russo, Nicola Antonino, Iervolino, Anna, Amodio, Federica, De Felice, Mario, Lucci, Valeria, Falco, Geppino
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.12.2019; MDPI
• Subjects: Amino acids; Animals; Body Patterning - genetics; Cell Differentiation; CRISPR; Embryonic Stem Cells - cytology; Embryonic Stem Cells - metabolism; Endoderm - embryology; Endoderm - metabolism; Gene Editing; Gene Expression Regulation, Developmental; Gene Targeting; Genetic Loci; Glucose; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - metabolism; Mice; Mice, Knockout; Pancreas; Polypeptides; Protein Isoforms - genetics; Proteins; Rodents; Stem cells; Thyroid gland; differentiation, definitive endoderm; transcriptional variants; mouse model; embryonic stem cells; (CRISPR)/CRISPR-associated systems 9 (Cas9); Nephrocan gene

Endoderm-derived organs as liver and pancreas are potential targets for regenerative therapies, and thus, there is great interest in understanding the pathways that regulate the induction and specification of this germ layer. Currently, the knowledge of molecular mechanisms that guide the in vivo en...