Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects

There is considerable interest in the potential of a group of dietary-derived phytochemicals known as flavonoids in modulating neuronal function and thereby influencing memory, learning and cognitive function. The present review begins by detailing the molecular events that underlie the acquisition...

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Published inProceedings of the Nutrition Society Vol. 71; no. 2; pp. 246 - 262
Main Authors Rendeiro, Catarina, Guerreiro, João D. T., Williams, Claire M., Spencer, Jeremy P. E.
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 01.05.2012
Subjects
Age
Alzheimer's disease
Animals
Behavior - drug effects
Bioavailability
blueberries
Brain
Cocoa
cognition
Cognition - drug effects
Cognition - physiology
Cognitive ability
Data processing
Diet
Dietary Supplements
Flavonoids
Flavonoids - pharmacology
Food
foods
Gene Expression - drug effects
genes
Ginkgo biloba
Green tea
Hippocampus
Hippocampus - drug effects
Hippocampus - physiology
Human subjects
Humans
Kinases
Learning
Learning - drug effects
Learning - physiology
Memory
Memory - drug effects
Memory - physiology
Metabolism
Metabolites
Neuromodulation
neurons
Nutrition
phytopharmaceuticals
Plant Extracts - pharmacology
Postgraduate Symposium
protein synthesis
Proteins
Proteins - metabolism
Reviews
Signal transduction
Signal Transduction - drug effects
Small intestine
Spatial discrimination learning
spatial memory
Tea
Transcription factors
Transcription Factors - metabolism
Translation
Vaccinium
United Kingdom > UK
Learning
Flavonoids
Memory
Hippocampus
Online AccessGet full text
ISSN0029-6651
1475-2719
1475-2719
DOI10.1017/S0029665112000146

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Abstract There is considerable interest in the potential of a group of dietary-derived phytochemicals known as flavonoids in modulating neuronal function and thereby influencing memory, learning and cognitive function. The present review begins by detailing the molecular events that underlie the acquisition and consolidation of new memories in the brain in order to provide a critical background to understanding the impact of flavonoid-rich diets or pure flavonoids on memory. Data suggests that despite limited brain bioavailability, dietary supplementation with flavonoid-rich foods, such as blueberry, green tea and Ginkgo biloba lead to significant reversals of age-related deficits on spatial memory and learning. Furthermore, animal and cellular studies suggest that the mechanisms underpinning their ability to induce improvements in memory are linked to the potential of absorbed flavonoids and their metabolites to interact with and modulate critical signalling pathways, transcription factors and gene and/or protein expression which control memory and learning processes in the hippocampus; the brain structure where spatial learning occurs. Overall, current evidence suggests that human translation of these animal investigations are warranted, as are further studies, to better understand the precise cause-and-effect relationship between flavonoid intake and cognitive outputs.
AbstractList There is considerable interest in the potential of a group of dietary-derived phytochemicals known as flavonoids in modulating neuronal function and thereby influencing memory, learning and cognitive function. The present review begins by detailing the molecular events that underlie the acquisition and consolidation of new memories in the brain in order to provide a critical background to understanding the impact of flavonoid-rich diets or pure flavonoids on memory. Data suggests that despite limited brain bioavailability, dietary supplementation with flavonoid-rich foods, such as blueberry, green tea and Ginkgo biloba lead to significant reversals of age-related deficits on spatial memory and learning. Furthermore, animal and cellular studies suggest that the mechanisms underpinning their ability to induce improvements in memory are linked to the potential of absorbed flavonoids and their metabolites to interact with and modulate critical signalling pathways, transcription factors and gene and/or protein expression which control memory and learning processes in the hippocampus; the brain structure where spatial learning occurs. Overall, current evidence suggests that human translation of these animal investigations are warranted, as are further studies, to better understand the precise cause-and-effect relationship between flavonoid intake and cognitive outputs.
There is considerable interest in the potential of a group of dietary-derived phytochemicals known as flavonoids in modulating neuronal function and thereby influencing memory, learning and cognitive function. The present review begins by detailing the molecular events that underlie the acquisition and consolidation of new memories in the brain in order to provide a critical background to understanding the impact of flavonoid-rich diets or pure flavonoids on memory. Data suggests that despite limited brain bioavailability, dietary supplementation with flavonoid-rich foods, such as blueberry, green tea and Ginkgo biloba lead to significant reversals of age-related deficits on spatial memory and learning. Furthermore, animal and cellular studies suggest that the mechanisms underpinning their ability to induce improvements in memory are linked to the potential of absorbed flavonoids and their metabolites to interact with and modulate critical signalling pathways, transcription factors and gene and/or protein expression which control memory and learning processes in the hippocampus; the brain structure where spatial learning occurs. Overall, current evidence suggests that human translation of these animal investigations are warranted, as are further studies, to better understand the precise cause-and-effect relationship between flavonoid intake and cognitive outputs.There is considerable interest in the potential of a group of dietary-derived phytochemicals known as flavonoids in modulating neuronal function and thereby influencing memory, learning and cognitive function. The present review begins by detailing the molecular events that underlie the acquisition and consolidation of new memories in the brain in order to provide a critical background to understanding the impact of flavonoid-rich diets or pure flavonoids on memory. Data suggests that despite limited brain bioavailability, dietary supplementation with flavonoid-rich foods, such as blueberry, green tea and Ginkgo biloba lead to significant reversals of age-related deficits on spatial memory and learning. Furthermore, animal and cellular studies suggest that the mechanisms underpinning their ability to induce improvements in memory are linked to the potential of absorbed flavonoids and their metabolites to interact with and modulate critical signalling pathways, transcription factors and gene and/or protein expression which control memory and learning processes in the hippocampus; the brain structure where spatial learning occurs. Overall, current evidence suggests that human translation of these animal investigations are warranted, as are further studies, to better understand the precise cause-and-effect relationship between flavonoid intake and cognitive outputs.
There is considerable interest in the potential of a group of dietary-derived phytochemicals known as flavonoids in modulating neuronal function and thereby influencing memory, learning and cognitive function. The present review begins by detailing the molecular events that underlie the acquisition and consolidation of new memories in the brain in order to provide a critical background to understanding the impact of flavonoid-rich diets or pure flavonoids on memory. Data suggests that despite limited brain bioavailability, dietary supplementation with flavonoid-rich foods, such as blueberry, green tea and Ginkgo biloba lead to significant reversals of age-related deficits on spatial memory and learning. Furthermore, animal and cellular studies suggest that the mechanisms underpinning their ability to induce improvements in memory are linked to the potential of absorbed flavonoids and their metabolites to interact with and modulate critical signalling pathways, transcription factors and gene and/or protein expression which control memory and learning processes in the hippocampus; the brain structure where spatial learning occurs. Overall, current evidence suggests that human translation of these animal investigations are warranted, as are further studies, to better understand the precise cause-and-effect relationship between flavonoid intake and cognitive outputs. [PUBLICATION ABSTRACT]
Author Spencer, Jeremy P. E.
Williams, Claire M.
Guerreiro, João D. T.
Rendeiro, Catarina
Author_xml – sequence: 1
  givenname: Catarina
  surname: Rendeiro
  fullname: Rendeiro, Catarina
  organization: 1Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AP, UK
– sequence: 2
  givenname: João D. T.
  surname: Guerreiro
  fullname: Guerreiro, João D. T.
  organization: 3Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, IST, Lisboa, Portugal
– sequence: 3
  givenname: Claire M.
  surname: Williams
  fullname: Williams, Claire M.
  organization: 2School of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6AL, UK
– sequence: 4
  givenname: Jeremy P. E.
  surname: Spencer
  fullname: Spencer, Jeremy P. E.
  email: j.p.e.spencer@reading.ac.uk
  organization: 1Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AP, UK
BackLink https://www.ncbi.nlm.nih.gov/pubmed/22414320$$D View this record in MEDLINE/PubMed
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Snippet There is considerable interest in the potential of a group of dietary-derived phytochemicals known as flavonoids in modulating neuronal function and thereby...
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SubjectTerms Age
Alzheimer's disease
Animals
Behavior - drug effects
Bioavailability
blueberries
Brain
Cocoa
cognition
Cognition - drug effects
Cognition - physiology
Cognitive ability
Data processing
Diet
Dietary Supplements
Flavonoids
Flavonoids - pharmacology
Food
foods
Gene Expression - drug effects
genes
Ginkgo biloba
Green tea
Hippocampus
Hippocampus - drug effects
Hippocampus - physiology
Human subjects
Humans
Kinases
Learning
Learning - drug effects
Learning - physiology
Memory
Memory - drug effects
Memory - physiology
Metabolism
Metabolites
Neuromodulation
neurons
Nutrition
phytopharmaceuticals
Plant Extracts - pharmacology
Postgraduate Symposium
protein synthesis
Proteins
Proteins - metabolism
Reviews
Signal transduction
Signal Transduction - drug effects
Small intestine
Spatial discrimination learning
spatial memory
Tea
Transcription factors
Transcription Factors - metabolism
Translation
Vaccinium
Title Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects
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https://www.ncbi.nlm.nih.gov/pubmed/22414320
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