The lyase activity of bifunctional DNA glycosylases and the 3′-diesterase activity of APE1 contribute to the repair of oxidized bases in nucleosomes

• Published in: Nucleic acids research Vol. 47; no. 6; pp. 2922 - 2931
• Main Authors: Maher, Robyn L, Wallace, Susan S, Pederson, David S
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 08.04.2019
• Subjects: Chromatin - enzymology; Chromatin - genetics; Deoxyribonuclease (Pyrimidine Dimer) - chemistry; Deoxyribonuclease (Pyrimidine Dimer) - genetics; DNA - chemistry; DNA - genetics; DNA Damage - genetics; DNA Glycosylases - chemistry; DNA Glycosylases - genetics; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase - chemistry; DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics; Esterases - genetics; Genome Integrity, Repair and; Humans; Lyases - chemistry; Lyases - genetics; Nucleosomes - enzymology; Nucleosomes - genetics; Oxidation-Reduction

Abstract The vast majority of oxidized bases that form in DNA are subject to base excision repair (BER). The DNA intermediates generated during successive steps in BER may prove mutagenic or lethal, making it critical that they be ‘handed’ from one BER enzyme to the next in a coordinated fashion. He...