Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer’s Disease and MCI: A Review
Alzheimer’s disease (AD) is a multifactorial, progressive, neurodegenerative disease typically characterized by memory loss, personality changes, and a decline in overall cognitive function. Usually manifesting in individuals over the age of 60, this is the most prevalent type of dementia and remain...
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| Published in | International journal of molecular sciences Vol. 24; no. 2; p. 1659 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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Switzerland
MDPI AG
14.01.2023
MDPI |
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| Online Access | Get full text |
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| Abstract | Alzheimer’s disease (AD) is a multifactorial, progressive, neurodegenerative disease typically characterized by memory loss, personality changes, and a decline in overall cognitive function. Usually manifesting in individuals over the age of 60, this is the most prevalent type of dementia and remains the fifth leading cause of death among Americans aged 65 and older. While the development of effective treatment and prevention for AD is a major healthcare goal, unfortunately, therapeutic approaches to date have yet to find a treatment plan that produces long-term cognitive improvement. Drugs that may be able to slow down the progression rate of AD are being introduced to the market; however, there has been no previous solution for preventing or reversing the disease-associated cognitive decline. Recent studies have identified several factors that contribute to the progression and severity of the disease: diet, lifestyle, stress, sleep, nutrient deficiencies, mental health, socialization, and toxins. Thus, increasing evidence supports dietary and other lifestyle changes as potentially effective ways to prevent, slow, or reverse AD progression. Studies also have demonstrated that a personalized, multi-therapeutic approach is needed to improve metabolic abnormalities and AD-associated cognitive decline. These studies suggest the effects of abnormalities, such as insulin resistance, chronic inflammation, hypovitaminosis D, hormonal deficiencies, and hyperhomocysteinemia, in the AD process. Therefore a personalized, multi-therapeutic program based on an individual’s genetics and biochemistry may be preferable over a single-drug/mono-therapeutic approach. This article reviews these multi-therapeutic strategies that identify and attenuate all the risk factors specific to each affected individual. This article systematically reviews studies that have incorporated multiple strategies that target numerous factors simultaneously to reverse or treat cognitive decline. We included high-quality clinical trials and observational studies that focused on the cognitive effects of programs comprising lifestyle, physical, and mental activity, as well as nutritional aspects. Articles from PubMed Central, Scopus, and Google Scholar databases were collected, and abstracts were reviewed for relevance to the subject matter. Epidemiological, pathological, toxicological, genetic, and biochemical studies have all concluded that AD represents a complex network insufficiency. The research studies explored in this manuscript confirm the need for a multifactorial approach to target the various risk factors of AD. A single-drug approach may delay the progression of memory loss but, to date, has not prevented or reversed it. Diet, physical activity, sleep, stress, and environment all contribute to the progression of the disease, and, therefore, a multi-factorial optimization of network support and function offers a rational therapeutic strategy. Thus, a multi-therapeutic program that simultaneously targets multiple factors underlying the AD network may be more effective than a mono-therapeutic approach. |
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| AbstractList | Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disease typically characterized by memory loss, personality changes, and a decline in overall cognitive function. Usually manifesting in individuals over the age of 60, this is the most prevalent type of dementia and remains the fifth leading cause of death among Americans aged 65 and older. While the development of effective treatment and prevention for AD is a major healthcare goal, unfortunately, therapeutic approaches to date have yet to find a treatment plan that produces long-term cognitive improvement. Drugs that may be able to slow down the progression rate of AD are being introduced to the market; however, there has been no previous solution for preventing or reversing the disease-associated cognitive decline. Recent studies have identified several factors that contribute to the progression and severity of the disease: diet, lifestyle, stress, sleep, nutrient deficiencies, mental health, socialization, and toxins. Thus, increasing evidence supports dietary and other lifestyle changes as potentially effective ways to prevent, slow, or reverse AD progression. Studies also have demonstrated that a personalized, multi-therapeutic approach is needed to improve metabolic abnormalities and AD-associated cognitive decline. These studies suggest the effects of abnormalities, such as insulin resistance, chronic inflammation, hypovitaminosis D, hormonal deficiencies, and hyperhomocysteinemia, in the AD process. Therefore a personalized, multi-therapeutic program based on an individual's genetics and biochemistry may be preferable over a single-drug/mono-therapeutic approach. This article reviews these multi-therapeutic strategies that identify and attenuate all the risk factors specific to each affected individual. This article systematically reviews studies that have incorporated multiple strategies that target numerous factors simultaneously to reverse or treat cognitive decline. We included high-quality clinical trials and observational studies that focused on the cognitive effects of programs comprising lifestyle, physical, and mental activity, as well as nutritional aspects. Articles from PubMed Central, Scopus, and Google Scholar databases were collected, and abstracts were reviewed for relevance to the subject matter. Epidemiological, pathological, toxicological, genetic, and biochemical studies have all concluded that AD represents a complex network insufficiency. The research studies explored in this manuscript confirm the need for a multifactorial approach to target the various risk factors of AD. A single-drug approach may delay the progression of memory loss but, to date, has not prevented or reversed it. Diet, physical activity, sleep, stress, and environment all contribute to the progression of the disease, and, therefore, a multi-factorial optimization of network support and function offers a rational therapeutic strategy. Thus, a multi-therapeutic program that simultaneously targets multiple factors underlying the AD network may be more effective than a mono-therapeutic approach.Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disease typically characterized by memory loss, personality changes, and a decline in overall cognitive function. Usually manifesting in individuals over the age of 60, this is the most prevalent type of dementia and remains the fifth leading cause of death among Americans aged 65 and older. While the development of effective treatment and prevention for AD is a major healthcare goal, unfortunately, therapeutic approaches to date have yet to find a treatment plan that produces long-term cognitive improvement. Drugs that may be able to slow down the progression rate of AD are being introduced to the market; however, there has been no previous solution for preventing or reversing the disease-associated cognitive decline. Recent studies have identified several factors that contribute to the progression and severity of the disease: diet, lifestyle, stress, sleep, nutrient deficiencies, mental health, socialization, and toxins. Thus, increasing evidence supports dietary and other lifestyle changes as potentially effective ways to prevent, slow, or reverse AD progression. Studies also have demonstrated that a personalized, multi-therapeutic approach is needed to improve metabolic abnormalities and AD-associated cognitive decline. These studies suggest the effects of abnormalities, such as insulin resistance, chronic inflammation, hypovitaminosis D, hormonal deficiencies, and hyperhomocysteinemia, in the AD process. Therefore a personalized, multi-therapeutic program based on an individual's genetics and biochemistry may be preferable over a single-drug/mono-therapeutic approach. This article reviews these multi-therapeutic strategies that identify and attenuate all the risk factors specific to each affected individual. This article systematically reviews studies that have incorporated multiple strategies that target numerous factors simultaneously to reverse or treat cognitive decline. We included high-quality clinical trials and observational studies that focused on the cognitive effects of programs comprising lifestyle, physical, and mental activity, as well as nutritional aspects. Articles from PubMed Central, Scopus, and Google Scholar databases were collected, and abstracts were reviewed for relevance to the subject matter. Epidemiological, pathological, toxicological, genetic, and biochemical studies have all concluded that AD represents a complex network insufficiency. The research studies explored in this manuscript confirm the need for a multifactorial approach to target the various risk factors of AD. A single-drug approach may delay the progression of memory loss but, to date, has not prevented or reversed it. Diet, physical activity, sleep, stress, and environment all contribute to the progression of the disease, and, therefore, a multi-factorial optimization of network support and function offers a rational therapeutic strategy. Thus, a multi-therapeutic program that simultaneously targets multiple factors underlying the AD network may be more effective than a mono-therapeutic approach. Alzheimer’s disease (AD) is a multifactorial, progressive, neurodegenerative disease typically characterized by memory loss, personality changes, and a decline in overall cognitive function. Usually manifesting in individuals over the age of 60, this is the most prevalent type of dementia and remains the fifth leading cause of death among Americans aged 65 and older. While the development of effective treatment and prevention for AD is a major healthcare goal, unfortunately, therapeutic approaches to date have yet to find a treatment plan that produces long-term cognitive improvement. Drugs that may be able to slow down the progression rate of AD are being introduced to the market; however, there has been no previous solution for preventing or reversing the disease-associated cognitive decline. Recent studies have identified several factors that contribute to the progression and severity of the disease: diet, lifestyle, stress, sleep, nutrient deficiencies, mental health, socialization, and toxins. Thus, increasing evidence supports dietary and other lifestyle changes as potentially effective ways to prevent, slow, or reverse AD progression. Studies also have demonstrated that a personalized, multi-therapeutic approach is needed to improve metabolic abnormalities and AD-associated cognitive decline. These studies suggest the effects of abnormalities, such as insulin resistance, chronic inflammation, hypovitaminosis D, hormonal deficiencies, and hyperhomocysteinemia, in the AD process. Therefore a personalized, multi-therapeutic program based on an individual’s genetics and biochemistry may be preferable over a single-drug/mono-therapeutic approach. This article reviews these multi-therapeutic strategies that identify and attenuate all the risk factors specific to each affected individual. This article systematically reviews studies that have incorporated multiple strategies that target numerous factors simultaneously to reverse or treat cognitive decline. We included high-quality clinical trials and observational studies that focused on the cognitive effects of programs comprising lifestyle, physical, and mental activity, as well as nutritional aspects. Articles from PubMed Central, Scopus, and Google Scholar databases were collected, and abstracts were reviewed for relevance to the subject matter. Epidemiological, pathological, toxicological, genetic, and biochemical studies have all concluded that AD represents a complex network insufficiency. The research studies explored in this manuscript confirm the need for a multifactorial approach to target the various risk factors of AD. A single-drug approach may delay the progression of memory loss but, to date, has not prevented or reversed it. Diet, physical activity, sleep, stress, and environment all contribute to the progression of the disease, and, therefore, a multi-factorial optimization of network support and function offers a rational therapeutic strategy. Thus, a multi-therapeutic program that simultaneously targets multiple factors underlying the AD network may be more effective than a mono-therapeutic approach. |
| Author | Coward, Christine Kelly, Lance Rao, Rammohan V. Okada, Sho Bredesen, Aida L. Bredesen, Dale E. Gregory, Julie Subramaniam, Kaavya G. |
| AuthorAffiliation | 3 Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90024, USA 2 Department of Psychology, University of California, Davis, CA 95616, USA 1 Apollo Health, Burlingame, CA 94011, USA |
| AuthorAffiliation_xml | – name: 2 Department of Psychology, University of California, Davis, CA 95616, USA – name: 3 Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90024, USA – name: 1 Apollo Health, Burlingame, CA 94011, USA |
| Author_xml | – sequence: 1 givenname: Rammohan V. surname: Rao fullname: Rao, Rammohan V. – sequence: 2 givenname: Kaavya G. surname: Subramaniam fullname: Subramaniam, Kaavya G. – sequence: 3 givenname: Julie surname: Gregory fullname: Gregory, Julie – sequence: 4 givenname: Aida L. surname: Bredesen fullname: Bredesen, Aida L. – sequence: 5 givenname: Christine surname: Coward fullname: Coward, Christine – sequence: 6 givenname: Sho surname: Okada fullname: Okada, Sho – sequence: 7 givenname: Lance surname: Kelly fullname: Kelly, Lance – sequence: 8 givenname: Dale E. surname: Bredesen fullname: Bredesen, Dale E. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36675177$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1007/s12603-014-0515-3 10.1212/WNL.0000000000003332 10.1007/s12603-012-0402-8 10.4061/2011/176709 10.3233/JAD-215120 10.1111/pcn.12539 10.2174/1871527315666151111121749 10.1111/j.1365-2869.2006.00499.x 10.1016/S0165-0173(97)00004-0 10.1016/j.exger.2008.04.002 10.1016/j.jalz.2018.02.014 10.5665/sleep.2802 10.1007/s12603-010-0052-7 10.1016/j.neuint.2020.104852 10.3390/vaccines9060679 10.1016/j.jalz.2016.06.2360 10.1034/j.1600-079X.2003.00065.x 10.1186/s12877-016-0342-y 10.1016/j.jmb.2019.01.018 10.2174/1567205012666150204121719 10.3389/fnagi.2022.948219 10.1016/j.clinthera.2018.05.004 10.1073/pnas.1721694115 10.1080/13543784.2017.1323868 10.1016/B978-0-12-822290-4.00012-8 10.1002/ana.22468 10.1001/jama.2022.4473 10.1001/jama.2009.1146 10.1523/JNEUROSCI.2797-06.2006 10.1001/archneur.58.3.397 10.1016/j.neurobiolaging.2005.09.026 10.1093/aje/kwm036 10.1016/j.bbi.2018.07.012 10.3389/fpsyt.2022.872594 10.3390/nu13113728 10.1016/j.ynstr.2018.04.002 10.1016/j.envint.2020.105546 10.1002/alz.12767 10.1002/hipo.23292 10.1016/j.cmet.2022.08.012 10.3233/JAD-210632 10.3233/JAD-151106 10.1016/j.envint.2020.106376 10.1371/journal.pone.0270682 10.1186/s13063-022-06699-7 10.3390/brainsci10110868 10.1097/EDE.0b013e3182944410 10.18632/aging.100981 10.1002/alz.12638 10.2174/1567205015666180119092427 10.1155/2020/5764017 10.1155/2013/513149 10.1007/s12264-016-0055-4 10.3389/fneur.2018.01058 10.1016/j.neurol.2019.07.017 10.3389/fphar.2010.00138 10.1186/s13024-021-00452-5 10.1016/j.jalz.2017.09.006 10.5935/0946-5448.20190014 10.3233/JAD-215707 10.3390/nu12041019 10.1016/j.arr.2017.05.007 10.5114/fn.2019.88449 10.3390/toxics8020021 10.1016/j.jalz.2019.04.001 10.1002/jnr.23827 10.1016/j.neuint.2020.104708 10.3389/fnhum.2021.739754 10.3389/fspor.2021.796101 10.1001/jama.2022.3550 10.1016/j.jalz.2016.02.002 10.3233/JAD-180468 10.2174/157015910792246209 10.1155/2015/620143 10.1016/j.phymed.2008.12.018 10.1056/NEJM199406233302501 10.1111/eci.13806 10.1016/j.jagp.2018.10.013 10.1038/s41586-022-05439-w 10.3389/fphar.2019.00695 10.1186/s12877-022-03455-z 10.3233/JAD-180005 10.1016/S0091-3057(03)00128-X 10.1186/alzrt125 10.3389/fnagi.2022.975711 10.1038/d41586-020-03084-9 10.1371/journal.pone.0126926 10.1017/S1041610217002162 10.1186/s13195-021-00788-6 10.1111/jgs.17208 10.1016/S0306-4530(02)00146-4 10.1016/j.jalz.2012.09.012 10.1093/advances/nmz054 10.1007/s11920-009-0004-2 10.1016/j.jalz.2018.10.001 10.1007/s11606-011-1640-x 10.1016/j.bbadis.2016.04.017 10.1016/j.trci.2018.02.003 10.20944/preprints201909.0270.v1 10.1007/s12035-019-01660-3 10.3233/JAD-190569 10.1016/S1098-3597(04)90014-2 10.3389/fimmu.2022.907804 10.3389/fnins.2018.00125 10.1073/pnas.0610080104 10.1007/s41999-021-00534-z 10.3233/JAD-201100 10.2522/ptj.20140212 10.1038/npp.2014.222 10.1159/000229024 10.3389/fnagi.2016.00277 10.1016/j.ebiom.2020.102883 10.2174/1871527316666170113120853 10.1136/bjsports-2016-096846 10.1111/j.1532-5415.2008.02167.x 10.1146/annurev-nutr-071715-050947 10.1016/j.gerinurse.2020.12.005 10.1186/s12974-022-02544-5 10.1159/000464269 10.14814/phy2.15158 10.3233/JAD-2007-11207 10.1212/WNL.0000000000006784 10.1523/JNEUROSCI.0730-11.2011 10.3233/JAD-142766 10.2174/1567205016666191010114744 10.3389/fpsyt.2015.00032 10.1001/jama.2009.1144 10.4103/0973-7847.134229 10.1176/jnp.2007.19.4.373 10.1089/acm.2007.0515 10.1038/srep40668 10.3390/ijms151120169 10.1038/s41598-022-06749-9 10.3390/nu13072264 10.1007/s004060050101 10.1007/s11920-014-0456-x 10.1177/0960327112456315 10.1161/CIRCULATIONAHA.120.050281 10.1177/0748233709348393 10.1523/JNEUROSCI.3562-15.2016 10.1016/j.scitotenv.2020.143734 10.1002/trc2.12318 10.1001/archneurol.2009.307 10.1055/s-0037-1604351 10.3390/ijms232012603 10.3389/fnhum.2017.00305 10.1016/j.jalz.2014.11.009 10.3233/JAD-132483 10.18632/aging.102849 10.1126/science.1074069 10.1007/s11920-022-01355-y 10.3928/00989134-20100330-05 10.3389/fnagi.2019.00315 10.1212/WNL.0000000000000240 10.2174/156720512799015046 10.1002/0471142301.ns1003s49 10.3390/geriatrics7020024 10.3390/ijms222212269 10.1016/j.exger.2022.111948 10.1038/nn.3303 10.3233/JAD-180183 10.3389/fnagi.2019.00269 10.1017/S1041610218002302 10.1080/01612840591008258 10.3310/hta23100 10.3389/fnins.2022.879480 10.1042/CS20050278 10.3389/fnagi.2019.00344 10.1007/s11356-020-09964-x 10.3233/JAD-200064 10.1007/s12035-017-0757-2 10.1016/j.tox.2013.02.002 10.1016/S0140-6736(15)60461-5 10.3389/fnagi.2022.845291 10.3233/JAD-190681 10.1176/appi.ajp.161.11.2081 10.2174/1386207323999201110192942 10.1002/alz.12008 10.3233/JAD-181054 10.1016/j.jamda.2016.11.026 10.3390/toxins13070477 10.1016/j.toxlet.2020.03.005 10.1093/sleep/zsw032 10.3390/ijms23094862 10.1016/j.jds.2022.07.001 10.1007/s10571-021-01154-8 10.3390/healthcare10081462 10.2174/156720501108140910122849 10.1093/nutrit/nuab057 10.1016/j.jagp.2018.11.002 10.1177/1757913918772602 10.1038/srep32222 10.1159/000494889 10.2174/1570159X15666170915141610 10.3390/ijms20112797 10.3390/biomedicines9101348 10.1126/science.372.6547.1141 10.1016/j.arr.2021.101504 10.1590/0004-282x20190149 10.1001/archneur.56.3.303 10.31083/j.jin2102073 10.3390/biom11040543 10.1080/13607860701529932 10.1016/j.jpsychores.2004.02.010 10.1016/j.cct.2021.106270 10.3233/JAD-220287 10.1017/S1041610205001997 10.3233/JAD-200282 10.1212/WNL.0000000000003537 10.1172/JCI59903 10.1089/107628004773933299 10.5214/ans.0972.7531.12190207 10.3389/fnagi.2022.771413 10.3233/JAD-200743 10.2174/1570159X15666170313123454 10.1016/j.scitotenv.2022.157114 10.1152/physrev.00032.2012 10.1111/jgs.16252 10.1093/advances/nmaa153 10.1093/geronb/52B.4.P159 10.1038/mp.2014.114 10.3389/fnhum.2014.00385 10.1590/1980-5764-dn-2021-0042 10.2174/157015910792246236 10.1016/j.clnu.2013.03.015 10.1186/s13024-022-00574-4 10.1007/s12035-013-8456-0 10.1038/s41430-017-0005-x 10.1080/09638288.2020.1830311 10.1111/j.1600-079X.2011.00937.x 10.7150/ijbs.66871 10.1038/srep15015 10.1186/s41232-022-00216-8 10.1161/HYPERTENSIONAHA.112.193995 10.1523/JNEUROSCI.2994-18.2019 10.1002/jnr.10441 10.1186/s13024-022-00559-3 10.1097/WCO.0000000000000346 10.3389/fnagi.2013.00005 10.1016/j.smrv.2012.06.007 10.1044/2022_AJSLP-21-00300 10.1097/MCO.0b013e3283331fe4 10.1177/1533317512456067 10.3389/fnagi.2020.561504 10.3389/fpsyg.2017.01657 10.1161/HYPERTENSIONAHA.112.193060 10.1038/s41380-021-01138-6 10.1073/pnas.0605194103 10.18632/aging.100896 10.1002/alz.12450 10.1016/j.pharmthera.2018.11.006 10.1186/1475-2875-10-S1-S4 10.1179/1476830511Y.0000000032 10.1097/WCO.0000000000000797 10.1016/j.trci.2017.06.005 10.1016/j.jalz.2015.04.011 10.1212/WNL.0000000000000964 10.1037/0894-4105.19.4.520 10.1016/j.jalz.2019.08.198 10.3945/jn.109.113910 10.3389/fnagi.2019.00043 10.1111/j.1600-079X.2004.00196.x |
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| Keywords | stress AD risk factors therapeutics Alzheimer’s disease neurodegeneration exercise cognitive decline herbs brain stimulation sleep supplements multi-therapeutic program diet |
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| References | Lehtisalo (ref_57) 2019; 15 ref_257 Berendsen (ref_47) 2019; 10 Huttenrauch (ref_83) 2021; 82 ref_259 Zhu (ref_181) 2020; 74 Abascal (ref_247) 2004; 10 Lista (ref_24) 2015; 19 Begega (ref_164) 2018; 16 Fiatarone (ref_75) 1994; 330 Jett (ref_272) 2022; 14 Yegambaram (ref_211) 2015; 12 Ouanes (ref_155) 2019; 11 Sadrameli (ref_231) 2020; 33 Schneider (ref_21) 2013; 17 Jayakody (ref_136) 2018; 12 Toups (ref_2) 2022; 88 Smith (ref_261) 2016; 36 Smith (ref_143) 2009; 57 Howes (ref_246) 2012; 9 Kattenstroth (ref_185) 2011; 2011 Llano (ref_134) 2021; 15 ref_248 Grassi (ref_56) 2012; 60 Bombois (ref_98) 2010; 14 Su (ref_162) 2016; 32 Tangvik (ref_262) 2021; 42 Maass (ref_70) 2015; 20 Medehouenou (ref_209) 2019; 18 Arellanes (ref_268) 2020; 59 Sood (ref_165) 2011; 26 ref_244 Wu (ref_77) 2022; 42 Wang (ref_260) 2022; 80 Farhang (ref_169) 2019; 31 Roach (ref_28) 2022; 8 Velazquez (ref_270) 2020; 12 Zucchella (ref_280) 2018; 9 Foley (ref_99) 2004; 56 Hill (ref_225) 2014; 6 Gomes (ref_189) 2022; 16 Vemuri (ref_142) 2016; 29 Deschenes (ref_101) 2009; 11 Parasuraman (ref_253) 2014; 8 Huat (ref_207) 2019; 431 Nous (ref_113) 2021; 13 Hsu (ref_78) 2018; 52 Piekut (ref_223) 2022; 21 Zhao (ref_203) 2021; 72 Mehta (ref_16) 2017; 26 Desideri (ref_55) 2012; 60 ref_156 Morris (ref_128) 2001; 58 Vasefi (ref_198) 2020; 141 Freberg (ref_73) 2022; 89 Vermunt (ref_127) 2019; 15 Hemmat (ref_237) 2022; 42 Ganz (ref_243) 2022; 17 Gascon (ref_212) 2020; 138 Guetin (ref_188) 2009; 28 Harrison (ref_160) 2015; 40 Rosenberg (ref_42) 2018; 14 Blumenthal (ref_38) 2020; 68 ref_88 Allen (ref_263) 2013; 32 ref_265 Tran (ref_205) 2022; 13 Bubu (ref_103) 2017; 40 Zhu (ref_180) 2022; 14 Reiter (ref_115) 2010; 8 Theodore (ref_50) 2021; 12 Wade (ref_120) 2014; 9 Pugazhenthi (ref_31) 2017; 1863 Rasoanaivo (ref_250) 2011; 10 Feart (ref_33) 2009; 302 Mahncke (ref_141) 2006; 103 Williams (ref_61) 2008; 12 Kumar (ref_186) 1999; 5 Nascimento (ref_68) 2014; 11 Manivannan (ref_210) 2019; 16 Letenneur (ref_54) 2007; 165 Danucalov (ref_163) 2013; 2013 Cunnane (ref_58) 2022; 52 Lehrer (ref_235) 2022; 34 Wu (ref_184) 2022; 14 Karkou (ref_183) 2017; 2 Mao (ref_233) 2022; 17 Davis (ref_130) 2018; 15 Levros (ref_13) 2013; 48 Boga (ref_117) 2012; 52 Izquierdo (ref_85) 2017; 37 Kivipelto (ref_5) 2013; 9 ref_202 Thumuluri (ref_182) 2021; 3 Scheyer (ref_273) 2018; 5 Martyr (ref_131) 2019; 3 Skaper (ref_124) 2017; 16 ref_201 Yu (ref_71) 2021; 80 Schikowski (ref_214) 2020; 136 Cardinali (ref_119) 2012; 1 Spinedi (ref_95) 2019; 108 Cardinali (ref_111) 2010; 8 Ngandu (ref_4) 2015; 385 Solfrizzi (ref_53) 2006; 27 Cummings (ref_278) 2022; 18 Cordone (ref_94) 2019; 10 Green (ref_158) 2006; 26 Nayor (ref_63) 2020; 142 Berendsen (ref_46) 2017; 18 Theendakara (ref_12) 2018; 55 Chen (ref_35) 2019; 67 ref_230 Ettcheto (ref_104) 2019; 11 Liu (ref_40) 2021; 102 Yeo (ref_277) 2022; 327 Forstl (ref_133) 1999; 249 Huang (ref_10) 2019; 39 Mendez (ref_137) 2021; 183 Wang (ref_92) 2018; 115 Chacko (ref_224) 2022; 12 Bredesen (ref_18) 2016; 8 Barha (ref_60) 2022; 23 Yu (ref_79) 2006; 38 Wei (ref_170) 2022; 44 ref_227 Shukla (ref_110) 2017; 15 ref_228 Alexandrov (ref_229) 2019; 57 Justice (ref_146) 2018; 8 ref_221 Bredesen (ref_22) 2018; 8 Bliwise (ref_106) 2004; 6 Yoshino (ref_72) 2022; 34 Park (ref_215) 2022; 86 Panza (ref_226) 2019; 142 Shcherbatykh (ref_200) 2007; 11 Bishir (ref_87) 2020; 2020 Dubois (ref_17) 2016; 12 Servick (ref_279) 2021; 372 Wu (ref_112) 2005; 38 Rondanelli (ref_118) 2012; 15 Mortamais (ref_216) 2021; 148 Cole (ref_269) 2010; 140 Blumenthal (ref_37) 2019; 92 Yan (ref_220) 2016; 6 Zhou (ref_114) 2003; 35 Kornblith (ref_275) 2022; 327 Bredesen (ref_197) 2016; 8 ref_19 Tranah (ref_102) 2011; 70 Dorris (ref_177) 2021; 69 ref_15 Nguyen (ref_27) 2022; 24 Rasch (ref_89) 2013; 93 Windle (ref_191) 2018; 30 Rahman (ref_271) 2019; 11 Mottaghi (ref_49) 2018; 72 Empting (ref_241) 2009; 25 Petersen (ref_129) 1999; 56 Smith (ref_39) 2019; 71 Brenes (ref_171) 2019; 27 Khalsa (ref_166) 2015; 48 Portugal (ref_65) 2015; 14 Beydoun (ref_232) 2020; 75 Teri (ref_76) 1997; 52 Schofield (ref_193) 2005; 17 Cortes (ref_138) 2018; 63 Kattenstroth (ref_179) 2010; 2 Fotuhi (ref_26) 2016; 3 Singh (ref_219) 2012; 27 Singh (ref_218) 2013; 32 Lupien (ref_150) 1997; 24 Merzenich (ref_122) 2014; 8 Sotiropoulos (ref_151) 2011; 31 Pisa (ref_204) 2015; 5 Feart (ref_44) 2010; 13 Lloyd (ref_157) 2004; 161 Isaacson (ref_6) 2019; 15 Hossain (ref_109) 2019; 56 Morris (ref_34) 2015; 11 Lavretsky (ref_172) 2019; 27 Theendakara (ref_8) 2016; 36 Maestu (ref_147) 2020; 12 Wilckens (ref_80) 2021; 31 Jensen (ref_190) 2018; 138 Clare (ref_144) 2019; 23 Innes (ref_173) 2016; 52 Barkat (ref_254) 2020; 24 Winstone (ref_213) 2022; 19 Canet (ref_153) 2019; 11 Kattenstroth (ref_178) 2013; 5 Baker (ref_69) 2010; 67 Yulug (ref_93) 2017; 71 Abbott (ref_242) 2020; 587 Ralli (ref_135) 2019; 23 Darweesh (ref_30) 2018; 14 Wang (ref_238) 2006; 110 Newberg (ref_167) 2012; 19 Pietrzak (ref_159) 2017; 2 Seto (ref_20) 2021; 16 Eckert (ref_256) 2010; 1 Phillips (ref_82) 2015; 95 Kudielka (ref_148) 2004; 29 Zaganas (ref_195) 2013; 307 Lim (ref_96) 2013; 36 Selkoe (ref_126) 2002; 298 Guercio (ref_217) 2021; 757 Ratnaseelan (ref_245) 2018; 40 ref_176 Queiroz (ref_222) 2022; 13 ref_52 Howes (ref_255) 2003; 75 Pfennig (ref_139) 2007; 19 Wennberg (ref_100) 2017; 37 Lupien (ref_149) 1997; 82 Best (ref_74) 2016; 87 Savage (ref_86) 2007; 104 Diaz (ref_9) 2022; 14 Teter (ref_121) 2002; 70 Morris (ref_43) 2015; 11 Baldwin (ref_140) 2009; 49 Mir (ref_199) 2020; 27 Talbot (ref_29) 2012; 122 Aloizou (ref_208) 2020; 326 Cole (ref_108) 2005; 26 Teixeira (ref_62) 2018; 4 Okonkwo (ref_66) 2014; 83 Bakulski (ref_206) 2020; 76 Cairns (ref_234) 2022; 88 Genuis (ref_194) 2015; 2015 James (ref_3) 2014; 82 Yang (ref_168) 2016; 8 Rehfeld (ref_174) 2017; 11 Cunnane (ref_59) 2021; 12 Pike (ref_274) 2017; 95 Blanchard (ref_11) 2022; 611 Lourida (ref_41) 2013; 24 Scarmeas (ref_84) 2009; 302 Nemergut (ref_236) 2022; 844 Wagner (ref_251) 2009; 16 Mehta (ref_276) 2017; 13 Wainberg (ref_239) 2021; 26 Berendsen (ref_45) 2017; 43 Poulos (ref_281) 2017; 3 Shen (ref_116) 2022; 18 Saharan (ref_266) 2014; 40 ref_36 Schreiner (ref_145) 2022; 16 ref_32 Rose (ref_105) 2010; 36 Urfer (ref_14) 2017; 7 Linard (ref_240) 2020; 16 Patwardhan (ref_252) 2008; 14 Du (ref_152) 2015; 6 Jackson (ref_97) 2013; 17 Roman (ref_51) 2019; 175 Varteresian (ref_258) 2014; 16 Tractenberg (ref_107) 2006; 15 Mandal (ref_267) 2019; 68 Jurewicz (ref_196) 2013; 26 Lyu (ref_175) 2018; 64 Ennis (ref_154) 2017; 88 Stickgold (ref_90) 2013; 16 Voss (ref_123) 2017; 8 Borges (ref_91) 2019; 77 Raulin (ref_7) 2022; 17 Schechter (ref_23) 2020; 4 Coutinho (ref_67) 2022; 168 Kojda (ref_81) 2008; 43 ref_187 ref_1 Jeppson (ref_192) 2022; 31 Fonken (ref_161) 2018; 73 Rao (ref_249) 2012; 4 Backman (ref_132) 2005; 19 ref_48 Lake (ref_64) 2022; 10 Pagano (ref_264) 2014; 15 Ross (ref_25) 2021; 11 Chen (ref_125) 2019; 195 |
| References_xml | – volume: 19 start-page: 154 year: 2015 ident: ref_24 article-title: Paths to Alzheimer’s disease prevention: From modifiable risk factors to biomarker enrichment strategies publication-title: J. Nutr. Health Aging doi: 10.1007/s12603-014-0515-3 – volume: 87 start-page: 2082 year: 2016 ident: ref_74 article-title: Aerobic exercise and vascular cognitive impairment: A randomized controlled trial publication-title: Neurology doi: 10.1212/WNL.0000000000003332 – volume: 17 start-page: 252 year: 2013 ident: ref_21 article-title: A review of multidomain interventions to support healthy cognitive ageing publication-title: J. Nutr. Health Aging doi: 10.1007/s12603-012-0402-8 – volume: 34 start-page: 97 year: 2022 ident: ref_235 article-title: Vaccination Reduces Risk of Alzheimer’s Disease, Parkinson’s Disease and Other Neurodegenerative Disorders publication-title: Discov. Med. – volume: 2011 start-page: 176709 year: 2011 ident: ref_185 article-title: Balance, sensorimotor, and cognitive performance in long-year expert senior ballroom dancers publication-title: J. Aging Res. doi: 10.4061/2011/176709 – volume: 86 start-page: 553 year: 2022 ident: ref_215 article-title: Impact of Long-Term Exposure to Air Pollution on Cognitive Decline in Older Adults Without Dementia publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-215120 – volume: 71 start-page: 673 year: 2017 ident: ref_93 article-title: Does sleep disturbance affect the amyloid clearance mechanisms in Alzheimer’s disease? publication-title: Psychiatry Clin. Neurosci. doi: 10.1111/pcn.12539 – volume: 14 start-page: 1209 year: 2015 ident: ref_65 article-title: Aging process, cognitive decline and Alzheimer`s disease: Can strength training modulate these responses? publication-title: CNS Neurol. Disord. Drug Targets doi: 10.2174/1871527315666151111121749 – volume: 15 start-page: 97 year: 2006 ident: ref_107 article-title: Characterizing sleep problems in persons with Alzheimer’s disease and normal elderly publication-title: J. Sleep Res. doi: 10.1111/j.1365-2869.2006.00499.x – volume: 24 start-page: 1 year: 1997 ident: ref_150 article-title: The acute effects of corticosteroids on cognition: Integration of animal and human model studies publication-title: Brain Res. Brain Res. Rev. doi: 10.1016/S0165-0173(97)00004-0 – volume: 43 start-page: 499 year: 2008 ident: ref_81 article-title: Alzheimer’s disease, cerebrovascular dysfunction and the benefits of exercise: From vessels to neurons publication-title: Exp. Gerontol doi: 10.1016/j.exger.2008.04.002 – volume: 14 start-page: 1450 year: 2018 ident: ref_30 article-title: Inflammatory markers and the risk of dementia and Alzheimer’s disease: A meta-analysis publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2018.02.014 – volume: 36 start-page: 1027 year: 2013 ident: ref_96 article-title: Sleep Fragmentation and the Risk of Incident Alzheimer’s Disease and Cognitive Decline in Older Persons publication-title: Sleep doi: 10.5665/sleep.2802 – volume: 14 start-page: 212 year: 2010 ident: ref_98 article-title: Sleep disorders in aging and dementia publication-title: J. Nutr. Health Aging doi: 10.1007/s12603-010-0052-7 – volume: 141 start-page: 104852 year: 2020 ident: ref_198 article-title: Environmental toxins and Alzheimer’s disease progression publication-title: Neurochem. Int. doi: 10.1016/j.neuint.2020.104852 – ident: ref_227 doi: 10.3390/vaccines9060679 – volume: 13 start-page: 72 year: 2017 ident: ref_276 article-title: Systematic review of dementia prevalence and incidence in United States race/ethnic populations publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2016.06.2360 – volume: 38 start-page: 358 year: 2006 ident: ref_79 article-title: Improving cognition and function through exercise intervention in Alzheimer’s disease publication-title: J. Nurs. Scholarsh. Off. Publ. Sigma Theta Tau Int. Honor Soc. Nurs. – volume: 35 start-page: 125 year: 2003 ident: ref_114 article-title: Early neuropathological Alzheimer’s changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels publication-title: J. Pineal Res. doi: 10.1034/j.1600-079X.2003.00065.x – ident: ref_202 doi: 10.1186/s12877-016-0342-y – volume: 431 start-page: 1843 year: 2019 ident: ref_207 article-title: Metal Toxicity Links to Alzheimer’s Disease and Neuroinflammation publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2019.01.018 – volume: 12 start-page: 116 year: 2015 ident: ref_211 article-title: Role of environmental contaminants in the etiology of Alzheimer’s disease: A review publication-title: Curr. Alzheimer Res. doi: 10.2174/1567205012666150204121719 – volume: 14 start-page: 948219 year: 2022 ident: ref_272 article-title: Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer’s disease publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2022.948219 – volume: 40 start-page: 903 year: 2018 ident: ref_245 article-title: Effects of Mycotoxins on Neuropsychiatric Symptoms and Immune Processes publication-title: Clin. Ther. doi: 10.1016/j.clinthera.2018.05.004 – volume: 115 start-page: 4483 year: 2018 ident: ref_92 article-title: beta-Amyloid accumulation in the human brain after one night of sleep deprivation publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1721694115 – volume: 26 start-page: 735 year: 2017 ident: ref_16 article-title: Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010–2015 publication-title: Expert Opin. Investig. Drugs doi: 10.1080/13543784.2017.1323868 – volume: 183 start-page: 261 year: 2021 ident: ref_137 article-title: Degenerative dementias: Alterations of emotions and mood disorders publication-title: Handb. Clin. Neurol. doi: 10.1016/B978-0-12-822290-4.00012-8 – volume: 70 start-page: 722 year: 2011 ident: ref_102 article-title: Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women publication-title: Ann. Neurol. doi: 10.1002/ana.22468 – volume: 327 start-page: 1454 year: 2022 ident: ref_277 article-title: Association of Race and Ethnicity With Dementia publication-title: JAMA doi: 10.1001/jama.2022.4473 – volume: 302 start-page: 638 year: 2009 ident: ref_33 article-title: Adherence to a Mediterranean diet, cognitive decline, and risk of dementia publication-title: JAMA doi: 10.1001/jama.2009.1146 – volume: 26 start-page: 9047 year: 2006 ident: ref_158 article-title: Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer’s disease publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2797-06.2006 – volume: 58 start-page: 397 year: 2001 ident: ref_128 article-title: Mild cognitive impairment represents early-stage Alzheimer disease publication-title: Arch. Neurol. doi: 10.1001/archneur.58.3.397 – volume: 27 start-page: 1694 year: 2006 ident: ref_53 article-title: Dietary intake of unsaturated fatty acids and age-related cognitive decline: A 8.5-year follow-up of the Italian Longitudinal Study on Aging publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2005.09.026 – volume: 165 start-page: 1364 year: 2007 ident: ref_54 article-title: Flavonoid intake and cognitive decline over a 10-year period publication-title: Am. J. Epidemiol. doi: 10.1093/aje/kwm036 – volume: 73 start-page: 133 year: 2018 ident: ref_161 article-title: Stress and aging act through common mechanisms to elicit neuroinflammatory priming publication-title: Brain. Behav. Immun. doi: 10.1016/j.bbi.2018.07.012 – volume: 13 start-page: 872594 year: 2022 ident: ref_222 article-title: The Gut Microbiota-Brain Axis: A New Frontier on Neuropsychiatric Disorders publication-title: Front. Psychiatry doi: 10.3389/fpsyt.2022.872594 – volume: 18 start-page: 57 year: 2019 ident: ref_209 article-title: Exposure to polychlorinated biphenyls and organochlorine pesticides and risk of dementia, Alzheimer’s disease and cognitive decline in an older population: A prospective analysis from the Canadian Study of Health and Aging publication-title: Environ. Health A Glob. Access. Sci. Sour. – ident: ref_32 doi: 10.3390/nu13113728 – volume: 8 start-page: 127 year: 2018 ident: ref_146 article-title: The relationship between stress and Alzheimer’s disease publication-title: Neurobiol. Stress doi: 10.1016/j.ynstr.2018.04.002 – volume: 138 start-page: 105546 year: 2020 ident: ref_212 article-title: Impact of urban environmental exposures on cognitive performance and brain structure of healthy individuals at risk for Alzheimer’s dementia publication-title: Environ. Int. doi: 10.1016/j.envint.2020.105546 – ident: ref_259 doi: 10.1002/alz.12767 – volume: 5 start-page: 225 year: 2018 ident: ref_273 article-title: Female Sex and Alzheimer’s Risk: The Menopause Connection publication-title: J. Prev. Alzheimer’s Dis. – volume: 31 start-page: 335 year: 2021 ident: ref_80 article-title: Exercise interventions preserve hippocampal volume: A meta-analysis publication-title: Hippocampus doi: 10.1002/hipo.23292 – volume: 34 start-page: 1431 year: 2022 ident: ref_72 article-title: Worksite-based intensive lifestyle therapy has profound cardiometabolic benefits in people with obesity and type 2 diabetes publication-title: Cell Metab. doi: 10.1016/j.cmet.2022.08.012 – volume: 89 start-page: 759 year: 2022 ident: ref_73 article-title: Exercise as a Potential Therapeutic Strategy to Target the Clinical Link Between Depression and Alzheimer’s Disease: A Narrative Review publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-210632 – volume: 52 start-page: 1277 year: 2016 ident: ref_173 article-title: Effects of Meditation versus Music Listening on Perceived Stress, Mood, Sleep, and Quality of Life in Adults with Early Memory Loss: A Pilot Randomized Controlled Trial publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-151106 – volume: 148 start-page: 106376 year: 2021 ident: ref_216 article-title: Long-term exposure to ambient air pollution and risk of dementia: Results of the prospective Three-City Study publication-title: Environ. Int. doi: 10.1016/j.envint.2020.106376 – ident: ref_187 doi: 10.1371/journal.pone.0270682 – volume: 23 start-page: 766 year: 2022 ident: ref_60 article-title: Reshaping the path of mild cognitive impairment by refining exercise prescription: A study protocol of a randomized controlled trial to understand the “what,” “for whom,” and “how” of exercise to promote cognitive function publication-title: Trials doi: 10.1186/s13063-022-06699-7 – ident: ref_88 doi: 10.3390/brainsci10110868 – volume: 24 start-page: 479 year: 2013 ident: ref_41 article-title: Mediterranean diet, cognitive function, and dementia: A systematic review publication-title: Epidemiology doi: 10.1097/EDE.0b013e3182944410 – volume: 8 start-page: 1250 year: 2016 ident: ref_18 article-title: Reversal of cognitive decline in Alzheimer’s disease publication-title: Aging doi: 10.18632/aging.100981 – ident: ref_1 doi: 10.1002/alz.12638 – volume: 15 start-page: 777 year: 2018 ident: ref_130 article-title: Estimating Alzheimer’s Disease Progression Rates from Normal Cognition Through Mild Cognitive Impairment and Stages of Dementia publication-title: Curr. Alzheimer Res. doi: 10.2174/1567205015666180119092427 – volume: 2020 start-page: 5764017 year: 2020 ident: ref_87 article-title: Sleep Deprivation and Neurological Disorders publication-title: Biomed Res. Int. doi: 10.1155/2020/5764017 – volume: 2013 start-page: 513149 year: 2013 ident: ref_163 article-title: A yoga and compassion meditation program reduces stress in familial caregivers of Alzheimer’s disease patients publication-title: Evid Based Complement Altern. Med. doi: 10.1155/2013/513149 – volume: 32 start-page: 469 year: 2016 ident: ref_162 article-title: Inflammatory Cytokines and Alzheimer’s Disease: A Review from the Perspective of Genetic Polymorphisms publication-title: Neurosci. Bull. doi: 10.1007/s12264-016-0055-4 – volume: 9 start-page: 1058 year: 2018 ident: ref_280 article-title: The Multidisciplinary Approach to Alzheimer’s Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment publication-title: Front. Neurol. doi: 10.3389/fneur.2018.01058 – volume: 175 start-page: 705 year: 2019 ident: ref_51 article-title: Extra-virgin olive oil for potential prevention of Alzheimer disease publication-title: Rev. Neurol. doi: 10.1016/j.neurol.2019.07.017 – volume: 1 start-page: 138 year: 2010 ident: ref_256 article-title: Traditional used Plants against Cognitive Decline and Alzheimer Disease publication-title: Front. Pharmacol. doi: 10.3389/fphar.2010.00138 – volume: 16 start-page: 29 year: 2021 ident: ref_20 article-title: Protective genes and pathways in Alzheimer’s disease: Moving towards precision interventions publication-title: Mol. Neurodegener. doi: 10.1186/s13024-021-00452-5 – volume: 14 start-page: 263 year: 2018 ident: ref_42 article-title: Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2017.09.006 – volume: 23 start-page: 79 year: 2019 ident: ref_135 article-title: Hearing loss and Alzheimer’s disease: A Review publication-title: Int. Tinnitus J. doi: 10.5935/0946-5448.20190014 – volume: 5 start-page: 49 year: 1999 ident: ref_186 article-title: Music therapy increases serum melatonin levels in patients with Alzheimer’s disease publication-title: Altern. Ther. Health Med. – volume: 2 start-page: CD011022 year: 2017 ident: ref_183 article-title: Dance movement therapy for dementia publication-title: Cochrane Database Syst. Rev. – volume: 88 start-page: 1411 year: 2022 ident: ref_2 article-title: Precision Medicine Approach to Alzheimer’s Disease: Successful Pilot Project publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-215707 – ident: ref_36 doi: 10.3390/nu12041019 – volume: 37 start-page: 117 year: 2017 ident: ref_85 article-title: Role of physical exercise on cognitive function in healthy older adults: A systematic review of randomized clinical trials publication-title: Ageing Res. Rev. doi: 10.1016/j.arr.2017.05.007 – volume: 57 start-page: 211 year: 2019 ident: ref_229 article-title: Lipopolysaccharide-stimulated, NF-kB-, miRNA-146a- and miRNA-155-mediated molecular-genetic communication between the human gastrointestinal tract microbiome and the brain publication-title: Folia Neuropathol. doi: 10.5114/fn.2019.88449 – ident: ref_221 doi: 10.3390/toxics8020021 – volume: 15 start-page: 888 year: 2019 ident: ref_127 article-title: Duration of preclinical, prodromal, and dementia stages of Alzheimer’s disease in relation to age, sex, and APOE genotype publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2019.04.001 – volume: 95 start-page: 671 year: 2017 ident: ref_274 article-title: Sex and the development of Alzheimer’s disease publication-title: J. Neurosci. Res. doi: 10.1002/jnr.23827 – volume: 136 start-page: 104708 year: 2020 ident: ref_214 article-title: The role of air pollution in cognitive impairment and decline publication-title: Neurochem. Int. doi: 10.1016/j.neuint.2020.104708 – volume: 15 start-page: 739754 year: 2021 ident: ref_134 article-title: Reported Hearing Loss in Alzheimer’s Disease Is Associated With Loss of Brainstem and Cerebellar Volume publication-title: Front. Hum. Neurosci. doi: 10.3389/fnhum.2021.739754 – volume: 3 start-page: 796101 year: 2021 ident: ref_182 article-title: Improvisational Movement to Improve Quality of Life in Older Adults With Early-Stage Dementia: A Pilot Study publication-title: Front. Sport Act. Living doi: 10.3389/fspor.2021.796101 – volume: 327 start-page: 1488 year: 2022 ident: ref_275 article-title: Association of Race and Ethnicity With Incidence of Dementia Among Older Adults publication-title: JAMA doi: 10.1001/jama.2022.3550 – volume: 12 start-page: 292 year: 2016 ident: ref_17 article-title: Proceedings of the Meeting of the International Working, G.; the American Alzheimer’s Association on “The Preclinical State of, A.D.; July; Washington Dc, U.S.A. Preclinical Alzheimer’s disease: Definition, natural history, and diagnostic criteria publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2016.02.002 – volume: 67 start-page: 583 year: 2019 ident: ref_35 article-title: Dietary Patterns and Cognitive Health in Older Adults: A Systematic Review publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-180468 – volume: 8 start-page: 218 year: 2010 ident: ref_111 article-title: Clinical aspects of melatonin intervention in Alzheimer’s disease progression publication-title: Curr. Neuropharmacol. doi: 10.2174/157015910792246209 – volume: 2015 start-page: 620143 year: 2015 ident: ref_194 article-title: Toxicant exposure and bioaccumulation: A common and potentially reversible cause of cognitive dysfunction and dementia publication-title: Behav. Neurol. doi: 10.1155/2015/620143 – volume: 16 start-page: 97 year: 2009 ident: ref_251 article-title: Synergy research: Approaching a new generation of phytopharmaceuticals publication-title: Phytomedicine doi: 10.1016/j.phymed.2008.12.018 – volume: 330 start-page: 1769 year: 1994 ident: ref_75 article-title: Exercise training and nutritional supplementation for physical frailty in very elderly people publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199406233302501 – volume: 52 start-page: e13806 year: 2022 ident: ref_58 article-title: Multimodal strategy to rescue the brain in mild cognitive impairment: Ketogenic oral nutrition supplementation with B vitamins and aerobic exercise publication-title: Eur. J. Clin. Investig. doi: 10.1111/eci.13806 – volume: 27 start-page: 188 year: 2019 ident: ref_171 article-title: The Effects of Yoga on Patients with Mild Cognitive Impairment and Dementia: A Scoping Review publication-title: Am. J. Geriatr. Psychiatry doi: 10.1016/j.jagp.2018.10.013 – volume: 611 start-page: 769 year: 2022 ident: ref_11 article-title: APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes publication-title: Nature doi: 10.1038/s41586-022-05439-w – volume: 10 start-page: 695 year: 2019 ident: ref_94 article-title: Sleep and beta-Amyloid Deposition in Alzheimer Disease: Insights on Mechanisms and Possible Innovative Treatments publication-title: Front. Pharmacol. doi: 10.3389/fphar.2019.00695 – ident: ref_156 doi: 10.1186/s12877-022-03455-z – volume: 63 start-page: 899 year: 2018 ident: ref_138 article-title: Behavioral and Neuropsychiatric Disorders in Alzheimer’s Disease publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-180005 – volume: 75 start-page: 513 year: 2003 ident: ref_255 article-title: Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function publication-title: Pharm. Biochem. Behav. doi: 10.1016/S0091-3057(03)00128-X – volume: 4 start-page: 22 year: 2012 ident: ref_249 article-title: Ayurvedic medicinal plants for Alzheimer’s disease: A review publication-title: Alzheimers Res. Ther. doi: 10.1186/alzrt125 – volume: 9 start-page: 947 year: 2014 ident: ref_120 article-title: Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer’s disease: A 6-month, randomized, placebo-controlled, multicenter trial publication-title: Clin. Interv. Aging – volume: 14 start-page: 975711 year: 2022 ident: ref_184 article-title: Dance movement therapy for neurodegenerative diseases: A systematic review publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2022.975711 – volume: 587 start-page: 22 year: 2020 ident: ref_242 article-title: Are infections seeding some cases of Alzheimer’s disease? publication-title: Nature doi: 10.1038/d41586-020-03084-9 – ident: ref_244 doi: 10.1371/journal.pone.0126926 – volume: 30 start-page: 409 year: 2018 ident: ref_191 article-title: The impact of a visual arts program on quality of life, communication, and well-being of people living with dementia: A mixed-methods longitudinal investigation publication-title: Int. Psychogeriatr. doi: 10.1017/S1041610217002162 – volume: 13 start-page: 52 year: 2021 ident: ref_113 article-title: Melatonin levels in the Alzheimer’s disease continuum: A systematic review publication-title: Alzheimers Res Ther. doi: 10.1186/s13195-021-00788-6 – volume: 69 start-page: 2659 year: 2021 ident: ref_177 article-title: Effects of music participation for mild cognitive impairment and dementia: A systematic review and meta-analysis publication-title: J. Am. Geriatr. Soc. doi: 10.1111/jgs.17208 – volume: 29 start-page: 83 year: 2004 ident: ref_148 article-title: HPA axis responses to laboratory psychosocial stress in healthy elderly adults, younger adults, and children: Impact of age and gender publication-title: Psychoneuroendocrinology doi: 10.1016/S0306-4530(02)00146-4 – volume: 9 start-page: 657 year: 2013 ident: ref_5 article-title: The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study design and progress publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2012.09.012 – volume: 10 start-page: 1040 year: 2019 ident: ref_47 article-title: The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets Are Associated with Less Cognitive Decline and a Lower Risk of Alzheimer’s Disease-A Review publication-title: Adv. Nutr. doi: 10.1093/advances/nmz054 – volume: 11 start-page: 20 year: 2009 ident: ref_101 article-title: Current treatments for sleep disturbances in individuals with dementia publication-title: Curr. Psychiatry Rep. doi: 10.1007/s11920-009-0004-2 – volume: 15 start-page: 410 year: 2019 ident: ref_57 article-title: Dietary changes and cognition over 2 years within a multidomain intervention trial-The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2018.10.001 – volume: 26 start-page: 858 year: 2011 ident: ref_165 article-title: Stress management and resilience training among Department of Medicine faculty: A pilot randomized clinical trial publication-title: J. Gen. Intern. Med. doi: 10.1007/s11606-011-1640-x – volume: 1863 start-page: 1037 year: 2017 ident: ref_31 article-title: Common neurodegenerative pathways in obesity, diabetes, and Alzheimer’s disease publication-title: Biochim. Et Biophys. Acta Mol. Basis Dis. doi: 10.1016/j.bbadis.2016.04.017 – volume: 4 start-page: 473 year: 2018 ident: ref_62 article-title: Cognitive and structural cerebral changes in amnestic mild cognitive impairment due to Alzheimer’s disease after multicomponent training publication-title: Alzheimer’s Dement. doi: 10.1016/j.trci.2018.02.003 – ident: ref_15 doi: 10.20944/preprints201909.0270.v1 – volume: 56 start-page: 8255 year: 2019 ident: ref_109 article-title: Melatonin in Alzheimer’s Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer’s Neuropathology publication-title: Mol. Neurobiol. doi: 10.1007/s12035-019-01660-3 – volume: 71 start-page: 921 year: 2019 ident: ref_39 article-title: Association Between Insulin Resistance, Plasma Leptin, and Neurocognition in Vascular Cognitive Impairment publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-190569 – volume: 6 start-page: S16 year: 2004 ident: ref_106 article-title: Sleep disorders in Alzheimer’s disease and other dementias publication-title: Clin. Cornerstone doi: 10.1016/S1098-3597(04)90014-2 – volume: 26 start-page: 185 year: 2013 ident: ref_196 article-title: Exposure to widespread environmental toxicants and children’s cognitive development and behavioral problems publication-title: Int. J. Occup. Med. Environ. Health – volume: 13 start-page: 907804 year: 2022 ident: ref_205 article-title: Neuroinflammation in neurodegeneration via microbial infections publication-title: Front. Immunol. doi: 10.3389/fimmu.2022.907804 – volume: 12 start-page: 125 year: 2018 ident: ref_136 article-title: Impact of Aging on the Auditory System and Related Cognitive Functions: A Narrative Review publication-title: Front. Neurosci. doi: 10.3389/fnins.2018.00125 – volume: 104 start-page: 1051 year: 2007 ident: ref_86 article-title: A quantitative, theoretical framework for understanding mammalian sleep publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0610080104 – volume: 12 start-page: 1285 year: 2021 ident: ref_59 article-title: Mild cognitive impairment: When nutrition helps brain energy rescue-a report from the EuGMS 2020 Congress publication-title: Eur. Geriatr. Med. doi: 10.1007/s41999-021-00534-z – volume: 80 start-page: 233 year: 2021 ident: ref_71 article-title: Cognitive Effects of Aerobic Exercise in Alzheimer’s Disease: A Pilot Randomized Controlled Trial publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-201100 – volume: 95 start-page: 1046 year: 2015 ident: ref_82 article-title: The Link Between Physical Activity and Cognitive Dysfunction in Alzheimer Disease publication-title: Phys. Ther. doi: 10.2522/ptj.20140212 – volume: 40 start-page: 831 year: 2015 ident: ref_160 article-title: Effects of inflammation on hippocampus and substantia nigra responses to novelty in healthy human participants publication-title: Neuropsychopharmacology doi: 10.1038/npp.2014.222 – volume: 28 start-page: 36 year: 2009 ident: ref_188 article-title: Effect of music therapy on anxiety and depression in patients with Alzheimer’s type dementia: Randomised, controlled study publication-title: Dement Geriatr. Cogn. Disord. doi: 10.1159/000229024 – volume: 8 start-page: 277 year: 2016 ident: ref_168 article-title: Neurochemical and Neuroanatomical Plasticity Following Memory Training and Yoga Interventions in Older Adults with Mild Cognitive Impairment publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2016.00277 – volume: 59 start-page: 102883 year: 2020 ident: ref_268 article-title: Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial publication-title: EBioMedicine doi: 10.1016/j.ebiom.2020.102883 – volume: 16 start-page: 220 year: 2017 ident: ref_124 article-title: Synaptic Plasticity, Dementia and Alzheimer Disease publication-title: CNS Neurol. Disord. Drug Targets doi: 10.2174/1871527316666170113120853 – volume: 52 start-page: 184 year: 2018 ident: ref_78 article-title: Aerobic exercise promotes executive functions and impacts functional neural activity among older adults with vascular cognitive impairment publication-title: Br. J. Sport. Med. doi: 10.1136/bjsports-2016-096846 – volume: 57 start-page: 594 year: 2009 ident: ref_143 article-title: A cognitive training program based on principles of brain plasticity: Results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study publication-title: J. Am. Geriatr. Soc. doi: 10.1111/j.1532-5415.2008.02167.x – volume: 36 start-page: 211 year: 2016 ident: ref_261 article-title: Homocysteine, B Vitamins, and Cognitive Impairment publication-title: Annu. Rev. Nutr. doi: 10.1146/annurev-nutr-071715-050947 – volume: 42 start-page: 117 year: 2021 ident: ref_262 article-title: Effects of oral nutrition supplements in persons with dementia: A systematic review publication-title: Geriatr. Nurs. doi: 10.1016/j.gerinurse.2020.12.005 – volume: 19 start-page: 193 year: 2022 ident: ref_213 article-title: Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFalpha: Implications for neurodegenerative disorders publication-title: J. Neuroinflamm. doi: 10.1186/s12974-022-02544-5 – volume: 43 start-page: 215 year: 2017 ident: ref_45 article-title: Association of Adherence to a Healthy Diet with Cognitive Decline in European and American Older Adults: A Meta-Analysis within the CHANCES Consortium publication-title: Dement. Geriatr. Cogn. Disord. doi: 10.1159/000464269 – volume: 10 start-page: e15158 year: 2022 ident: ref_64 article-title: Aerobic exercise training in older men and women-Cerebrovascular responses to submaximal exercise: Results from the Brain in Motion study publication-title: Physiol. Rep. doi: 10.14814/phy2.15158 – volume: 11 start-page: 191 year: 2007 ident: ref_200 article-title: The role of metals in the etiology of Alzheimer’s disease publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-2007-11207 – volume: 92 start-page: e212 year: 2019 ident: ref_37 article-title: Lifestyle and neurocognition in older adults with cognitive impairments: A randomized trial publication-title: Neurology doi: 10.1212/WNL.0000000000006784 – volume: 31 start-page: 7840 year: 2011 ident: ref_151 article-title: Stress acts cumulatively to precipitate Alzheimer’s disease-like tau pathology and cognitive deficits publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0730-11.2011 – volume: 11 start-page: 18 year: 2021 ident: ref_25 article-title: Case Study: A Precision Medicine Approach to Multifactorial Dementia and Alzheimer’s Disease publication-title: J. Alzheimer’s Dis. Parkinsonism – volume: 48 start-page: 1 year: 2015 ident: ref_166 article-title: Stress, Meditation, and Alzheimer’s Disease Prevention: Where The Evidence Stands publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-142766 – volume: 16 start-page: 1039 year: 2019 ident: ref_210 article-title: Assessment of Persistent, Bioaccumulative and Toxic Organic Environmental Pollutants in Liver and Adipose Tissue of Alzheimer’s Disease Patients and Age-matched Controls publication-title: Curr. Alzheimer Res. doi: 10.2174/1567205016666191010114744 – volume: 6 start-page: 32 year: 2015 ident: ref_152 article-title: Is Dysregulation of the HPA-Axis a Core Pathophysiology Mediating Co-Morbid Depression in Neurodegenerative Diseases? publication-title: Front. Psychiatry doi: 10.3389/fpsyt.2015.00032 – volume: 302 start-page: 627 year: 2009 ident: ref_84 article-title: Physical activity, diet, and risk of Alzheimer disease publication-title: JAMA doi: 10.1001/jama.2009.1144 – volume: 8 start-page: 73 year: 2014 ident: ref_253 article-title: Polyherbal formulation: Concept of ayurveda publication-title: Pharmacogn. Rev. doi: 10.4103/0973-7847.134229 – volume: 19 start-page: 373 year: 2007 ident: ref_139 article-title: Neurocognitive impairment and dementia in mood disorders publication-title: J. Neuropsychiatry Clin. Neurosci. doi: 10.1176/jnp.2007.19.4.373 – volume: 14 start-page: 571 year: 2008 ident: ref_252 article-title: Ayurvedic genomics: Establishing a genetic basis for mind-body typologies publication-title: J. Altern. Complement. Med. doi: 10.1089/acm.2007.0515 – volume: 7 start-page: 40668 year: 2017 ident: ref_14 article-title: Identification of a Nuclear Respiratory Factor 1 Recognition Motif in the Apolipoprotein E Variant APOE4 linked to Alzheimer’s Disease publication-title: Sci. Rep. doi: 10.1038/srep40668 – volume: 15 start-page: 20169 year: 2014 ident: ref_264 article-title: Current experience in testing mitochondrial nutrients in disorders featuring oxidative stress and mitochondrial dysfunction: Rational design of chemoprevention trials publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms151120169 – volume: 12 start-page: 2759 year: 2022 ident: ref_224 article-title: Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk publication-title: Sci. Rep. doi: 10.1038/s41598-022-06749-9 – ident: ref_48 doi: 10.3390/nu13072264 – volume: 249 start-page: 288 year: 1999 ident: ref_133 article-title: Clinical features of Alzheimer’s disease publication-title: Eur. Arch. Psychiatry Clin. Neurosci. doi: 10.1007/s004060050101 – volume: 16 start-page: 456 year: 2014 ident: ref_258 article-title: Natural products and supplements for geriatric depression and cognitive disorders: An evaluation of the research publication-title: Curr. Psychiatry Rep. doi: 10.1007/s11920-014-0456-x – volume: 32 start-page: 24 year: 2013 ident: ref_218 article-title: Organochlorine pesticide levels and risk of Alzheimer’s disease in north Indian population publication-title: Hum. Exp. Toxicol. doi: 10.1177/0960327112456315 – volume: 3 start-page: CD013069 year: 2019 ident: ref_131 article-title: Cognitive training for people with mild to moderate dementia publication-title: Cochrane Database Syst. Rev. – volume: 142 start-page: 1905 year: 2020 ident: ref_63 article-title: Metabolic Architecture of Acute Exercise Response in Middle-Aged Adults in the Community publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.120.050281 – volume: 25 start-page: 577 year: 2009 ident: ref_241 article-title: Neurologic and neuropsychiatric syndrome features of mold and mycotoxin exposure publication-title: Toxicol. Ind. Health doi: 10.1177/0748233709348393 – volume: 36 start-page: 685 year: 2016 ident: ref_8 article-title: Direct Transcriptional Effects of Apolipoprotein E publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3562-15.2016 – volume: 757 start-page: 143734 year: 2021 ident: ref_217 article-title: A critical review of the epidemiological evidence of effects of air pollution on dementia, cognitive function and cognitive decline in adult population publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2020.143734 – volume: 8 start-page: e12318 year: 2022 ident: ref_28 article-title: The Coaching for Cognition in Alzheimer’s (COCOA) trial: Study design publication-title: Alzheimer’s Dement. doi: 10.1002/trc2.12318 – volume: 67 start-page: 71 year: 2010 ident: ref_69 article-title: Effects of aerobic exercise on mild cognitive impairment: A controlled trial publication-title: Arch. Neurol. doi: 10.1001/archneurol.2009.307 – volume: 37 start-page: 395 year: 2017 ident: ref_100 article-title: Sleep Disturbance, Cognitive Decline, and Dementia: A Review publication-title: Semin. Neurol. doi: 10.1055/s-0037-1604351 – ident: ref_265 doi: 10.3390/ijms232012603 – volume: 11 start-page: 305 year: 2017 ident: ref_174 article-title: Dancing or Fitness Sport? The Effects of Two Training Programs on Hippocampal Plasticity and Balance Abilities in Healthy Seniors publication-title: Front. Hum. Neurosci. doi: 10.3389/fnhum.2017.00305 – volume: 142 start-page: 2905 year: 2019 ident: ref_226 article-title: Time to test antibacterial therapy in Alzheimer’s disease publication-title: Brain – volume: 11 start-page: 1007 year: 2015 ident: ref_43 article-title: MIND diet associated with reduced incidence of Alzheimer’s disease publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2014.11.009 – volume: 4 start-page: 223 year: 2020 ident: ref_23 article-title: A Comprehensive, Multi-Modal Strategy to Mitigate Alzheimer’s Disease Risk Factors Improves Aspects of Metabolism and Offsets Cognitive Decline in Individuals with Cognitive Impairment publication-title: J. Alzheimer’s Dis. Rep. – volume: 40 start-page: 519 year: 2014 ident: ref_266 article-title: The emerging role of glutathione in Alzheimer’s disease publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-132483 – volume: 12 start-page: 2026 year: 2020 ident: ref_270 article-title: Choline as a prevention for Alzheimer’s disease publication-title: Aging doi: 10.18632/aging.102849 – volume: 8 start-page: 450 year: 2018 ident: ref_22 article-title: Reversal of Cognitive Decline: 100 Patients publication-title: J. Alzheimer’s Dis. Park. – volume: 298 start-page: 789 year: 2002 ident: ref_126 article-title: Alzheimer’s disease is a synaptic failure publication-title: Science doi: 10.1126/science.1074069 – volume: 24 start-page: 469 year: 2022 ident: ref_27 article-title: Complementary and Integrative Medicine for Neurocognitive Disorders and Caregiver Health publication-title: Curr. Psychiatry Rep. doi: 10.1007/s11920-022-01355-y – volume: 36 start-page: 9 year: 2010 ident: ref_105 article-title: Sleep disturbances in dementia publication-title: J. Gerontol. Nurs. doi: 10.3928/00989134-20100330-05 – volume: 11 start-page: 315 year: 2019 ident: ref_271 article-title: Sex and Gender Driven Modifiers of Alzheimer’s: The Role for Estrogenic Control Across Age, Race, Medical, and Lifestyle Risks publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2019.00315 – volume: 82 start-page: 1045 year: 2014 ident: ref_3 article-title: Contribution of Alzheimer disease to mortality in the United States publication-title: Neurology doi: 10.1212/WNL.0000000000000240 – volume: 9 start-page: 67 year: 2012 ident: ref_246 article-title: Ethnobotanical treatment strategies against Alzheimer’s disease publication-title: Curr. Alzheimer Res. doi: 10.2174/156720512799015046 – volume: 49 start-page: 10 year: 2009 ident: ref_140 article-title: Neuropsychological assessment in the diagnosis of Alzheimer’s disease publication-title: Curr. Protoc. Neurosci. doi: 10.1002/0471142301.ns1003s49 – ident: ref_257 doi: 10.3390/geriatrics7020024 – volume: 6 start-page: 127 year: 2014 ident: ref_225 article-title: Pathogenic microbes, the microbiome, and Alzheimer’s disease (AD) publication-title: Front. Aging Neurosci. – ident: ref_230 doi: 10.3390/ijms222212269 – volume: 168 start-page: 111948 year: 2022 ident: ref_67 article-title: Alzheimer’s disease genes and proteins associated with resistance and aerobic training: An in silico analysis publication-title: Exp. Gerontol. doi: 10.1016/j.exger.2022.111948 – volume: 16 start-page: 139 year: 2013 ident: ref_90 article-title: Sleep-dependent memory triage: Evolving generalization through selective processing publication-title: Nat. Neurosci. doi: 10.1038/nn.3303 – volume: 64 start-page: 1347 year: 2018 ident: ref_175 article-title: The Effects of Music Therapy on Cognition, Psychiatric Symptoms, and Activities of Daily Living in Patients with Alzheimer’s Disease publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-180183 – volume: 11 start-page: 269 year: 2019 ident: ref_153 article-title: Is AD a Stress-Related Disorder? Focus on the HPA Axis and Its Promising Therapeutic Targets publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2019.00269 – volume: 31 start-page: 643 year: 2019 ident: ref_169 article-title: Impact of mind-body interventions in older adults with mild cognitive impairment: A systematic review publication-title: Int. Psychogeriatr. doi: 10.1017/S1041610218002302 – volume: 26 start-page: 687 year: 2005 ident: ref_108 article-title: Sleep and cognition in people with Alzheimer’s disease publication-title: Issues Ment. Health Nurs. doi: 10.1080/01612840591008258 – volume: 23 start-page: 1 year: 2019 ident: ref_144 article-title: Goal-oriented cognitive rehabilitation for early-stage Alzheimer’s and related dementias: The GREAT RCT publication-title: Health Technol. Assess. doi: 10.3310/hta23100 – volume: 82 start-page: 2070 year: 1997 ident: ref_149 article-title: Stress-induced declarative memory impairment in healthy elderly subjects: Relationship to cortisol reactivity publication-title: J. Clin. Endocrinol. Metab. – volume: 16 start-page: 879480 year: 2022 ident: ref_145 article-title: Alzheimer’s Disease, Hearing Loss, and Deviance Detection publication-title: Front. Neurosci. doi: 10.3389/fnins.2022.879480 – volume: 110 start-page: 393 year: 2006 ident: ref_238 article-title: Viruses and the brain: From inflammation to dementia publication-title: Clin. Sci. doi: 10.1042/CS20050278 – volume: 11 start-page: 344 year: 2019 ident: ref_104 article-title: Benzodiazepines and Related Drugs as a Risk Factor in Alzheimer’s Disease Dementia publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2019.00344 – volume: 27 start-page: 44724 year: 2020 ident: ref_199 article-title: Role of environmental pollutants in Alzheimer’s disease: A review publication-title: Environ. Sci. Pollut. Res. Int. doi: 10.1007/s11356-020-09964-x – volume: 75 start-page: 157 year: 2020 ident: ref_232 article-title: Clinical and Bacterial Markers of Periodontitis and Their Association with Incident All-Cause and Alzheimer’s Disease Dementia in a Large National Survey publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-200064 – volume: 3 start-page: 133 year: 2016 ident: ref_26 article-title: A Personalized 12-week “Brain Fitness Program” for Improving Cognitive Function and Increasing the Volume of Hippocampus in Elderly with Mild Cognitive Impairment publication-title: J. Prev. Alzheimer’s Dis. – volume: 55 start-page: 5243 year: 2018 ident: ref_12 article-title: Transcriptional Effects of ApoE4: Relevance to Alzheimer’s Disease publication-title: Mol. Neurobiol. doi: 10.1007/s12035-017-0757-2 – volume: 307 start-page: 3 year: 2013 ident: ref_195 article-title: Linking pesticide exposure and dementia: What is the evidence? publication-title: Toxicology doi: 10.1016/j.tox.2013.02.002 – volume: 2 start-page: 31 year: 2010 ident: ref_179 article-title: Superior sensory, motor, and cognitive performance in elderly individuals with multi-year dancing activities publication-title: Front. Aging Neurosci. – volume: 385 start-page: 2255 year: 2015 ident: ref_4 article-title: A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): A randomised controlled trial publication-title: Lancet doi: 10.1016/S0140-6736(15)60461-5 – volume: 14 start-page: 845291 year: 2022 ident: ref_9 article-title: Apolipoprotein E4 Effects a Distinct Transcriptomic Profile and Dendritic Arbor Characteristics in Hippocampal Neurons Cultured in vitro publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2022.845291 – volume: 74 start-page: 679 year: 2020 ident: ref_181 article-title: Effects of Aerobic Dance on Cognition in Older Adults with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-190681 – volume: 161 start-page: 2081 year: 2004 ident: ref_157 article-title: A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.161.11.2081 – volume: 24 start-page: 1573 year: 2020 ident: ref_254 article-title: Herbal Medicine: Clinical Perspective & Regulatory Status publication-title: Comb. Chem. High Throughput Screen. doi: 10.2174/1386207323999201110192942 – volume: 16 start-page: 200 year: 2020 ident: ref_240 article-title: Interaction between APOE4 and herpes simplex virus type 1 in Alzheimer’s disease publication-title: Alzheimers Dement doi: 10.1002/alz.12008 – volume: 68 start-page: 531 year: 2019 ident: ref_267 article-title: Cognitive Improvement with Glutathione Supplement in Alzheimer’s Disease: A Way Forward publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-181054 – volume: 18 start-page: 427 year: 2017 ident: ref_46 article-title: The Dietary Approaches to Stop Hypertension Diet, Cognitive Function, and Cognitive Decline in American Older Women publication-title: J. Am. Med. Dir. Assoc. doi: 10.1016/j.jamda.2016.11.026 – ident: ref_201 doi: 10.3390/toxins13070477 – volume: 326 start-page: 31 year: 2020 ident: ref_208 article-title: Pesticides, cognitive functions and dementia: A review publication-title: Toxicol. Lett. doi: 10.1016/j.toxlet.2020.03.005 – volume: 40 start-page: zsw032 year: 2017 ident: ref_103 article-title: Sleep, Cognitive impairment, and Alzheimer’s disease: A Systematic Review and Meta-Analysis publication-title: Sleep doi: 10.1093/sleep/zsw032 – ident: ref_228 doi: 10.3390/ijms23094862 – volume: 17 start-page: 1762 year: 2022 ident: ref_233 article-title: Association of periodontitis and oral microbiomes with Alzheimer’s disease: A narrative systematic review publication-title: J. Dent. Sci. doi: 10.1016/j.jds.2022.07.001 – volume: 42 start-page: 2849 year: 2022 ident: ref_237 article-title: The Analysis of Herpes Simplex Virus Type 1 (HSV-1)-Encoded MicroRNAs Targets: A Likely Relationship of Alzheimer’s Disease and HSV-1 Infection publication-title: Cell. Mol. Neurobiol. doi: 10.1007/s10571-021-01154-8 – ident: ref_176 doi: 10.3390/healthcare10081462 – volume: 11 start-page: 799 year: 2014 ident: ref_68 article-title: Physical exercise in MCI elderly promotes reduction of pro-inflammatory cytokines and improvements on cognition and BDNF peripheral levels publication-title: Curr. Alzheimer Res. doi: 10.2174/156720501108140910122849 – volume: 80 start-page: 931 year: 2022 ident: ref_260 article-title: B vitamins and prevention of cognitive decline and incident dementia: A systematic review and meta-analysis publication-title: Nutr. Rev. doi: 10.1093/nutrit/nuab057 – volume: 27 start-page: 198 year: 2019 ident: ref_172 article-title: Yoga and Meditation Can Help Improve Cognitive Functioning in Older Adults With Mild Cognitive Impairment and Dementia publication-title: Am. J. Geriatr. Psychiatry doi: 10.1016/j.jagp.2018.11.002 – volume: 138 start-page: 209 year: 2018 ident: ref_190 article-title: The use of arts interventions for mental health and wellbeing in health settings publication-title: Perspect. Public Health doi: 10.1177/1757913918772602 – volume: 6 start-page: 32222 year: 2016 ident: ref_220 article-title: Pesticide exposure and risk of Alzheimer’s disease: A systematic review and meta-analysis publication-title: Sci. Rep. doi: 10.1038/srep32222 – volume: 108 start-page: 354 year: 2019 ident: ref_95 article-title: Neuroendocrine-Metabolic Dysfunction and Sleep Disturbances in Neurodegenerative Disorders: Focus on Alzheimer’s Disease and Melatonin publication-title: Neuroendocrinology doi: 10.1159/000494889 – volume: 16 start-page: 284 year: 2018 ident: ref_164 article-title: Coping with Stress During Aging: The Importance of a Resilient Brain publication-title: Curr. Neuropharmacol. doi: 10.2174/1570159X15666170915141610 – ident: ref_52 doi: 10.3390/ijms20112797 – ident: ref_19 doi: 10.3390/biomedicines9101348 – volume: 372 start-page: 1141 year: 2021 ident: ref_279 article-title: Alzheimer’s drug approved despite murky results publication-title: Science doi: 10.1126/science.372.6547.1141 – volume: 72 start-page: 101504 year: 2021 ident: ref_203 article-title: Environmental factors and risks of cognitive impairment and dementia: A systematic review and meta-analysis publication-title: Ageing Res. Rev. doi: 10.1016/j.arr.2021.101504 – volume: 77 start-page: 815 year: 2019 ident: ref_91 article-title: Alzheimer’s disease and sleep disturbances: A review publication-title: Arq. Neuropsiquiatr. doi: 10.1590/0004-282x20190149 – volume: 56 start-page: 303 year: 1999 ident: ref_129 article-title: Mild cognitive impairment: Clinical characterization and outcome publication-title: Arch. Neurol. doi: 10.1001/archneur.56.3.303 – volume: 21 start-page: 73 year: 2022 ident: ref_223 article-title: Infectious agents and Alzheimer’s disease publication-title: J. Integr. Neurosci. doi: 10.31083/j.jin2102073 – ident: ref_248 doi: 10.3390/biom11040543 – volume: 12 start-page: 72 year: 2008 ident: ref_61 article-title: Exercise training for depressed older adults with Alzheimer’s disease publication-title: Aging Ment. Health doi: 10.1080/13607860701529932 – volume: 56 start-page: 497 year: 2004 ident: ref_99 article-title: Sleep disturbances and chronic disease in older adults: Results of the 2003 National Sleep Foundation Sleep in America Survey publication-title: J. Psychosom. Res. doi: 10.1016/j.jpsychores.2004.02.010 – volume: 102 start-page: 106270 year: 2021 ident: ref_40 article-title: Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study: Rationale, design and baseline characteristics of a randomized control trial of the MIND diet on cognitive decline publication-title: Contemp. Clin. Trials doi: 10.1016/j.cct.2021.106270 – volume: 88 start-page: 1189 year: 2022 ident: ref_234 article-title: Potential Involvement of Varicella Zoster Virus in Alzheimer’s Disease via Reactivation of Quiescent Herpes Simplex Virus Type 1 publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-220287 – volume: 17 start-page: S129 year: 2005 ident: ref_193 article-title: Dementia associated with toxic causes and autoimmune disease publication-title: Int. Psychogeriatr. doi: 10.1017/S1041610205001997 – volume: 76 start-page: 1215 year: 2020 ident: ref_206 article-title: Heavy Metals Exposure and Alzheimer’s Disease and Related Dementias publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-200282 – volume: 88 start-page: 371 year: 2017 ident: ref_154 article-title: Long-term cortisol measures predict Alzheimer disease risk publication-title: Neurology doi: 10.1212/WNL.0000000000003537 – volume: 122 start-page: 1316 year: 2012 ident: ref_29 article-title: Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline publication-title: J. Clin. Investig. doi: 10.1172/JCI59903 – volume: 2 start-page: 45 year: 2017 ident: ref_159 article-title: Plasma Cortisol, Brain Amyloid-beta, and Cognitive Decline in Preclinical Alzheimer’s Disease: A 6-Year Prospective Cohort Study publication-title: Biol. Psychiatry Cogn. Neurosci. Neuroimaging – volume: 10 start-page: 67 year: 2004 ident: ref_247 article-title: Alzheimer’s Disease-Part 2—A Botanical Treatment Plan publication-title: Altern. Complement. Ther. doi: 10.1089/107628004773933299 – volume: 19 start-page: 81 year: 2012 ident: ref_167 article-title: Meditation effects on cognitive function and cerebral blood flow in subjects with memory loss: A preliminary study publication-title: Ann. Neurosci. doi: 10.5214/ans.0972.7531.12190207 – volume: 14 start-page: 771413 year: 2022 ident: ref_180 article-title: Effect of 3-Month Aerobic Dance on Hippocampal Volume and Cognition in Elderly People With Amnestic Mild Cognitive Impairment: A Randomized Controlled Trial publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2022.771413 – volume: 82 start-page: S65 year: 2021 ident: ref_83 article-title: Connecting Mind-Body Therapy-Mediated Effects to Pathological Features of Alzheimer’s Disease publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-200743 – volume: 15 start-page: 1010 year: 2017 ident: ref_110 article-title: Mechanisms of Melatonin in Alleviating Alzheimer’s Disease publication-title: Curr. Neuropharmacol. doi: 10.2174/1570159X15666170313123454 – volume: 844 start-page: 157114 year: 2022 ident: ref_236 article-title: Increased occurrence of Treponema spp. and double-species infections in patients with Alzheimer’s disease publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2022.157114 – volume: 93 start-page: 681 year: 2013 ident: ref_89 article-title: About sleep’s role in memory publication-title: Physiol. Rev. doi: 10.1152/physrev.00032.2012 – volume: 68 start-page: 559 year: 2020 ident: ref_38 article-title: Longer Term Effects of Diet and Exercise on Neurocognition: 1-Year Follow-up of the ENLIGHTEN Trial publication-title: J. Am. Geriatr. Soc. doi: 10.1111/jgs.16252 – volume: 12 start-page: 777 year: 2021 ident: ref_50 article-title: Nut Consumption for Cognitive Performance: A Systematic Review publication-title: Adv. Nutr. doi: 10.1093/advances/nmaa153 – volume: 52 start-page: P159 year: 1997 ident: ref_76 article-title: Behavioral treatment of depression in dementia patients: A controlled clinical trial publication-title: J. Gerontol. B Psychol. Sci. Soc. Sci. doi: 10.1093/geronb/52B.4.P159 – volume: 20 start-page: 585 year: 2015 ident: ref_70 article-title: Vascular hippocampal plasticity after aerobic exercise in older adults publication-title: Mol. Psychiatry doi: 10.1038/mp.2014.114 – volume: 8 start-page: 385 year: 2014 ident: ref_122 article-title: Brain plasticity-based therapeutics publication-title: Front. Hum. Neurosci. doi: 10.3389/fnhum.2014.00385 – volume: 16 start-page: 8 year: 2022 ident: ref_189 article-title: The impacts of visual Art Therapy for elderly with Neurocognitive disorder: A systematic review publication-title: Dement. Neuropsychol. doi: 10.1590/1980-5764-dn-2021-0042 – volume: 8 start-page: 194 year: 2010 ident: ref_115 article-title: Neurotoxins: Free radical mechanisms and melatonin protection publication-title: Curr. Neuropharmacol. doi: 10.2174/157015910792246236 – volume: 32 start-page: 950 year: 2013 ident: ref_263 article-title: Use of nutritional complete supplements in older adults with dementia: Systematic review and meta-analysis of clinical outcomes publication-title: Clin. Nutr. doi: 10.1016/j.clnu.2013.03.015 – volume: 17 start-page: 72 year: 2022 ident: ref_7 article-title: ApoE in Alzheimer’s disease: Pathophysiology and therapeutic strategies publication-title: Mol. Neurodegener. doi: 10.1186/s13024-022-00574-4 – volume: 48 start-page: 669 year: 2013 ident: ref_13 article-title: Binding and repressive activities of apolipoprotein E3 and E4 isoforms on the human ApoD promoter publication-title: Mol. Neurobiol. doi: 10.1007/s12035-013-8456-0 – volume: 72 start-page: 1336 year: 2018 ident: ref_49 article-title: Fruit and vegetable intake and cognitive impairment: A systematic review and meta-analysis of observational studies publication-title: Eur. J. Clin. Nutr. doi: 10.1038/s41430-017-0005-x – volume: 44 start-page: 2197 year: 2022 ident: ref_170 article-title: The impact of Tai Chi on cognitive rehabilitation of elder adults with mild cognitive impairment: A systematic review and meta-analysis publication-title: Disabil. Rehabil. doi: 10.1080/09638288.2020.1830311 – volume: 52 start-page: 167 year: 2012 ident: ref_117 article-title: Alzheimer’s disease: Pathological mechanisms and the beneficial role of melatonin publication-title: J. Pineal Res. doi: 10.1111/j.1600-079X.2011.00937.x – volume: 18 start-page: 983 year: 2022 ident: ref_116 article-title: The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer’s disease publication-title: Int. J. Biol. Sci. doi: 10.7150/ijbs.66871 – volume: 5 start-page: 15015 year: 2015 ident: ref_204 article-title: Different Brain Regions are Infected with Fungi in Alzheimer’s Disease publication-title: Sci. Rep. doi: 10.1038/srep15015 – volume: 42 start-page: 31 year: 2022 ident: ref_77 article-title: Therapeutic non-invasive brain treatments in Alzheimer’s disease: Recent advances and challenges publication-title: Inflamm. Regen. doi: 10.1186/s41232-022-00216-8 – volume: 1 start-page: 280 year: 2012 ident: ref_119 article-title: Therapeutic application of melatonin in mild cognitive impairment publication-title: Am. J. Neurodegener. Dis. – volume: 60 start-page: 827 year: 2012 ident: ref_56 article-title: Protective effects of flavanol-rich dark chocolate on endothelial function and wave reflection during acute hyperglycemia publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.112.193995 – volume: 39 start-page: 7408 year: 2019 ident: ref_10 article-title: Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer’s Disease Risk publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2994-18.2019 – volume: 70 start-page: 402 year: 2002 ident: ref_121 article-title: Neuroplasticity in Alzheimer’s disease publication-title: J. Neurosci Res. doi: 10.1002/jnr.10441 – volume: 17 start-page: 53 year: 2022 ident: ref_243 article-title: When the infectious environment meets the AD brain publication-title: Mol. Neurodegener. doi: 10.1186/s13024-022-00559-3 – volume: 29 start-page: 405 year: 2016 ident: ref_142 article-title: Cognitive interventions in Alzheimer’s and Parkinson’s diseases: Emerging mechanisms and role of imaging publication-title: Curr. Opin. Neurol. doi: 10.1097/WCO.0000000000000346 – volume: 5 start-page: 5 year: 2013 ident: ref_178 article-title: Six months of dance intervention enhances postural, sensorimotor, and cognitive performance in elderly without affecting cardio-respiratory functions publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2013.00005 – volume: 17 start-page: 215 year: 2013 ident: ref_97 article-title: Deconstructing and reconstructing cognitive performance in sleep deprivation publication-title: Sleep Med. Rev. doi: 10.1016/j.smrv.2012.06.007 – volume: 31 start-page: 1687 year: 2022 ident: ref_192 article-title: Painting for a Purpose: A Visual Arts Program as a Method to Promote Engagement, Communication, Cognition, and Quality of Life for Individuals With Dementia publication-title: Am. J. Speech-Lang. Pathol. doi: 10.1044/2022_AJSLP-21-00300 – volume: 13 start-page: 14 year: 2010 ident: ref_44 article-title: Mediterranean diet and cognitive function in older adults publication-title: Curr. Opin. Clin. Nutr. Metab. Care doi: 10.1097/MCO.0b013e3283331fe4 – volume: 27 start-page: 496 year: 2012 ident: ref_219 article-title: Mitrabasu, Gene-environment interaction in Alzheimer’s disease publication-title: Am. J. Alzheimer’s Dis. Other Dement. doi: 10.1177/1533317512456067 – volume: 12 start-page: 561504 year: 2020 ident: ref_147 article-title: The Role of Chronic Stress as a Trigger for the Alzheimer Disease Continuum publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2020.561504 – volume: 8 start-page: 1657 year: 2017 ident: ref_123 article-title: Dynamic Brains and the Changing Rules of Neuroplasticity: Implications for Learning and Recovery publication-title: Front. Psychol. doi: 10.3389/fpsyg.2017.01657 – volume: 60 start-page: 794 year: 2012 ident: ref_55 article-title: Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: The Cocoa, Cognition, and Aging (CoCoA) study publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.112.193060 – volume: 26 start-page: 5476 year: 2021 ident: ref_239 article-title: The viral hypothesis: How herpesviruses may contribute to Alzheimer’s disease publication-title: Mol. Psychiatry doi: 10.1038/s41380-021-01138-6 – volume: 103 start-page: 12523 year: 2006 ident: ref_141 article-title: Memory enhancement in healthy older adults using a brain plasticity-based training program: A randomized, controlled study publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0605194103 – volume: 8 start-page: 304 year: 2016 ident: ref_197 article-title: Inhalational Alzheimer’s disease: An unrecognized–and treatable–epidemic publication-title: Aging doi: 10.18632/aging.100896 – volume: 18 start-page: 469 year: 2022 ident: ref_278 article-title: The costs of developing treatments for Alzheimer’s disease: A retrospective exploration publication-title: Alzheimers Dement doi: 10.1002/alz.12450 – volume: 195 start-page: 186 year: 2019 ident: ref_125 article-title: Synaptic dysfunction in Alzheimer’s disease: Mechanisms and therapeutic strategies publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2018.11.006 – volume: 10 start-page: S4 year: 2011 ident: ref_250 article-title: Whole plant extracts versus single compounds for the treatment of malaria: Synergy and positive interactions publication-title: Malar. J. doi: 10.1186/1475-2875-10-S1-S4 – volume: 15 start-page: 46 year: 2012 ident: ref_118 article-title: Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment publication-title: Nutr. Neurosci. doi: 10.1179/1476830511Y.0000000032 – volume: 33 start-page: 230 year: 2020 ident: ref_231 article-title: Linking mechanisms of periodontitis to Alzheimer’s disease publication-title: Curr. Opin. Neurol. doi: 10.1097/WCO.0000000000000797 – volume: 3 start-page: 450 year: 2017 ident: ref_281 article-title: A comprehensive approach to reablement in dementia publication-title: Alzheimer’s Dement. doi: 10.1016/j.trci.2017.06.005 – volume: 11 start-page: 1015 year: 2015 ident: ref_34 article-title: MIND diet slows cognitive decline with aging publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2015.04.011 – volume: 83 start-page: 1753 year: 2014 ident: ref_66 article-title: Physical activity attenuates age-related biomarker alterations in preclinical AD publication-title: Neurology doi: 10.1212/WNL.0000000000000964 – volume: 19 start-page: 520 year: 2005 ident: ref_132 article-title: Cognitive impairment in preclinical Alzheimer’s disease: A meta-analysis publication-title: Neuropsychology doi: 10.1037/0894-4105.19.4.520 – volume: 15 start-page: 1588 year: 2019 ident: ref_6 article-title: Individualized clinical management of patients at risk for Alzheimer’s dementia publication-title: Alzheimers Dement doi: 10.1016/j.jalz.2019.08.198 – volume: 140 start-page: 869 year: 2010 ident: ref_269 article-title: DHA may prevent age-related dementia publication-title: J. Nutr. doi: 10.3945/jn.109.113910 – volume: 11 start-page: 43 year: 2019 ident: ref_155 article-title: High Cortisol and the Risk of Dementia and Alzheimer’s Disease: A Review of the Literature publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2019.00043 – volume: 38 start-page: 145 year: 2005 ident: ref_112 article-title: The human pineal gland and melatonin in aging and Alzheimer’s disease publication-title: J. Pineal Res. doi: 10.1111/j.1600-079X.2004.00196.x |
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| Snippet | Alzheimer’s disease (AD) is a multifactorial, progressive, neurodegenerative disease typically characterized by memory loss, personality changes, and a decline... Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disease typically characterized by memory loss, personality changes, and a decline... |
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| SubjectTerms | Alzheimer Disease - pathology Alzheimer's disease Cognition Cognitive Dysfunction - drug therapy Dietary supplements Exercise Humans Memory Disorders - complications Neurodegenerative Diseases - complications Review Vitamin E |
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| Title | Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer’s Disease and MCI: A Review |
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