Comparison of SOX2 and POU5F1 Gene Expression in Leukapheresis-Derived CD34+ Cells before and during Cell Culture

• Published in: International journal of molecular sciences Vol. 24; no. 4; p. 4186
• Main Authors: Świstowska, Małgorzata, Gil-Kulik, Paulina, Czop, Marcin, Wieczorek, Katarzyna, Macheta, Arkadiusz, Petniak, Alicja, Cioch, Maria, Hus, Marek, Szuta, Mariusz, Rahnama-Hezavah, Mansur, Płachno, Bartosz J., Kocki, Janusz
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.02.2023; MDPI
• Subjects: Antigens, CD34; Body fat; Bone marrow; Cell culture; Cell Culture Techniques; Cell cycle; Cell division; Communication; Dental pulp; Gene Expression; Humans; Leukapheresis; Octamer Transcription Factor-3 - genetics; SOXB1 Transcription Factors - genetics; Stem cell transplantation; Transcription factors; Transcription Factors - metabolism; SOX2; CD34+ PBSCs; cell culture; POU5F1

Bone marrow is an abundant source of both hematopoietic as well as non-hematopoietic stem cells. Embryonic, fetal and stem cells located in tissues (adipose tissue, skin, myocardium and dental pulp) express core transcription factors, including the SOX2, POU5F1 and NANOG gene responsible for regener...