Reprogramming the rapid clearance of thrombolytics by nanoparticle encapsulation and anchoring to circulating red blood cells

• Published in: Journal of controlled release Vol. 329; pp. 148 - 161
• Main Authors: Singh, Mohit Pratap, Flynn, Nicholas H., Sethuraman, Sri Nandhini, Manouchehri, Saeed, Ritchey, Jerry, Liu, Jing, Ramsey, Joshua D., Pope, Carey, Ranjan, Ashish
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.01.2021
• Subjects: Erythrocyte; Glycophorin A; Nanoparticle; Polymer; Red blood cell; Ter119; Erythrocyte; Glycophorin A; Red blood cell; Polymer; Ter119; Nanoparticle

Rapid clearance of thrombolytics from blood following intravenous injection is a major clinical challenge in cardiovascular medicine. To overcome this barrier, nanoparticle (NP) based drug delivery systems have been reported. Although superior than conventional therapy, a large proportion of the inj...