Genome-Wide DNA Alterations in X-Irradiated Human Gingiva Fibroblasts

• Published in: International journal of molecular sciences Vol. 21; no. 16; p. 5778
• Main Authors: Nath, Neetika, Hagenau, Lisa, Weiss, Stefan, Tzvetkova, Ana, Jensen, Lars R., Kaderali, Lars, Port, Matthias, Scherthan, Harry, Kuss, Andreas W.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.08.2020; MDPI
• Subjects: Chromosomes; Chromosomes, Human, Pair 19 - genetics; Databases, Genetic; Datasets; Deoxyribonucleic acid; DNA; DNA - genetics; DNA - radiation effects; DNA Copy Number Variations - genetics; DNA repair; Fibroblasts - pathology; Fibroblasts - radiation effects; Genome, Human; Genomes; Gingiva - cytology; Humans; INDEL Mutation - genetics; Mutation; Translocation, Genetic; Whole genome sequencing; X-Rays; topological associating domains; translocation; transition transversion ratio; IR-induced variants; InDels; radiation doses; repair mechanism; SNVs

While ionizing radiation (IR) is a powerful tool in medical diagnostics, nuclear medicine, and radiology, it also is a serious threat to the integrity of genetic material. Mutagenic effects of IR to the human genome have long been the subject of research, yet still comparatively little is known abou...