The Phenomenon of Clopidogrel High On-Treatment Platelet Reactivity in Ischemic Stroke Subjects: A Comprehensive Review

• Published in: International journal of molecular sciences Vol. 21; no. 17; p. 6408
• Main Authors: Wiśniewski, Adam, Filipska, Karolina
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.09.2020; MDPI
• Subjects: Adenosine diphosphate; Advantages; Aspirin; Blood Platelets - drug effects; Blood Platelets - physiology; Cardiovascular disease; Clopidogrel - therapeutic use; Cytochrome; Disease prevention; Flow cytometry; Genes; Glycoproteins; Humans; Ischemic Stroke - blood; Ischemic Stroke - drug therapy; Liver; Metabolism; Metabolites; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - therapeutic use; Prognosis; Review; Secondary Prevention; Stroke; France; United States > US; clopidogrel; platelet reactivity; antiplatelet therapy; platelet function; ischemic stroke; platelets; resistance

Clopidogrel is increasingly being used for the secondary prevention of ischemic stroke according to the updated guidelines on acute stroke management. Failure to achieve a drug response is referred to as clopidogrel resistance. Similarly, a higher activation of platelets during clopidogrel therapy—h...