Implementation of a protocol for management of antepartum iron deficiency anemia: a prospective cohort study
In randomized trials, antepartum intravenous iron sucrose is effective at improving predelivery hemoglobin in iron deficiency anemia. Yet, there is a gap between this knowledge and its implementation into care. We aimed to determine if the implementation of a standardized protocol for the management...
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Published in | American journal of obstetrics & gynecology MFM Vol. 4; no. 2; p. 100533 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
01.03.2022
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Abstract | In randomized trials, antepartum intravenous iron sucrose is effective at improving predelivery hemoglobin in iron deficiency anemia. Yet, there is a gap between this knowledge and its implementation into care.
We aimed to determine if the implementation of a standardized protocol for the management of antepartum anemia outside of a clinical trial improves intravenous iron sucrose utilization and clinical outcomes.
We performed a prospective cohort study evaluating the incorporation of an anemia protocol into routine clinical care for women with antepartum hemoglobin <11.0 g/dL. Our protocol, developed with multidisciplinary stakeholders, included (1) serial third trimester hemoglobin assessment, (2) oral iron supplementation for antepartum hemoglobin 9.5–11 g/dL, and (3) antepartum intravenous iron sucrose use (300 mg weekly for 3 weeks) for hemoglobin <9.5 g/dL. We compared 6-months preimplementation (January 2018 to June 2018) to 6-months postimplementation (January 2019 to June 2019). The outcomes evaluated were antepartum intravenous iron sucrose utilization, the number of intravenous iron sucrose dosages, predelivery hemoglobin, and blood transfusion.
A total of 1423 women were included (pre=778; post=645) without significant baseline differences. The antepartum hemoglobin nadir was no different between the groups (pre: 10.2; interquartile range [9.6–10.6] vs post: 10.2; interquartile range [9.6–10.6]; P=.77). The implementation of a standardized protocol for the management of antepartum anemia was associated with 80% increased odds of receiving intravenous iron sucrose than the preimplementation group (pre: 4.8% vs post: 8.2%, P=.008; odds ratio, 1.79; 95% confidence interval, [1.16–2.77]). The implementation of a standardized protocol for the management of antepartum iron deficiency anemia was also associated with higher hemoglobin at admission for delivery (pre: 10.9; interquartile range [10.1–11.6] vs post: 11.0; interquartile range [10.3–11.7], P=.048). There were no significant differences between the groups in blood product transfusion (pre: 7.1% vs post: 5.1%, P=.13).
Implementation of a standardized antepartum anemia protocol is associated with increased intravenous iron sucrose utilization and improvement in predelivery hemoglobin. |
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AbstractList | In randomized trials, antepartum intravenous iron sucrose is effective at improving predelivery hemoglobin in iron deficiency anemia. Yet, there is a gap between this knowledge and its implementation into care.
We aimed to determine if the implementation of a standardized protocol for the management of antepartum anemia outside of a clinical trial improves intravenous iron sucrose utilization and clinical outcomes.
We performed a prospective cohort study evaluating the incorporation of an anemia protocol into routine clinical care for women with antepartum hemoglobin <11.0 g/dL. Our protocol, developed with multidisciplinary stakeholders, included (1) serial third trimester hemoglobin assessment, (2) oral iron supplementation for antepartum hemoglobin 9.5–11 g/dL, and (3) antepartum intravenous iron sucrose use (300 mg weekly for 3 weeks) for hemoglobin <9.5 g/dL. We compared 6-months preimplementation (January 2018 to June 2018) to 6-months postimplementation (January 2019 to June 2019). The outcomes evaluated were antepartum intravenous iron sucrose utilization, the number of intravenous iron sucrose dosages, predelivery hemoglobin, and blood transfusion.
A total of 1423 women were included (pre=778; post=645) without significant baseline differences. The antepartum hemoglobin nadir was no different between the groups (pre: 10.2; interquartile range [9.6–10.6] vs post: 10.2; interquartile range [9.6–10.6]; P=.77). The implementation of a standardized protocol for the management of antepartum anemia was associated with 80% increased odds of receiving intravenous iron sucrose than the preimplementation group (pre: 4.8% vs post: 8.2%, P=.008; odds ratio, 1.79; 95% confidence interval, [1.16–2.77]). The implementation of a standardized protocol for the management of antepartum iron deficiency anemia was also associated with higher hemoglobin at admission for delivery (pre: 10.9; interquartile range [10.1–11.6] vs post: 11.0; interquartile range [10.3–11.7], P=.048). There were no significant differences between the groups in blood product transfusion (pre: 7.1% vs post: 5.1%, P=.13).
Implementation of a standardized antepartum anemia protocol is associated with increased intravenous iron sucrose utilization and improvement in predelivery hemoglobin. BACKGROUNDIn randomized trials, antepartum intravenous iron sucrose is effective at improving predelivery hemoglobin in iron deficiency anemia. Yet, there is a gap between this knowledge and its implementation into care.OBJECTIVEWe aimed to determine if the implementation of a standardized protocol for the management of antepartum anemia outside of a clinical trial improves intravenous iron sucrose utilization and clinical outcomes.STUDY DESIGNWe performed a prospective cohort study evaluating the incorporation of an anemia protocol into routine clinical care for women with antepartum hemoglobin <11.0 g/dL. Our protocol, developed with multidisciplinary stakeholders, included (1) serial third trimester hemoglobin assessment, (2) oral iron supplementation for antepartum hemoglobin 9.5-11 g/dL, and (3) antepartum intravenous iron sucrose use (300 mg weekly for 3 weeks) for hemoglobin <9.5 g/dL. We compared 6-months preimplementation (January 2018 to June 2018) to 6-months postimplementation (January 2019 to June 2019). The outcomes evaluated were antepartum intravenous iron sucrose utilization, the number of intravenous iron sucrose dosages, predelivery hemoglobin, and blood transfusion.RESULTSA total of 1423 women were included (pre=778; post=645) without significant baseline differences. The antepartum hemoglobin nadir was no different between the groups (pre: 10.2; interquartile range [9.6-10.6] vs post: 10.2; interquartile range [9.6-10.6]; P=.77). The implementation of a standardized protocol for the management of antepartum anemia was associated with 80% increased odds of receiving intravenous iron sucrose than the preimplementation group (pre: 4.8% vs post: 8.2%, P=.008; odds ratio, 1.79; 95% confidence interval, [1.16-2.77]). The implementation of a standardized protocol for the management of antepartum iron deficiency anemia was also associated with higher hemoglobin at admission for delivery (pre: 10.9; interquartile range [10.1-11.6] vs post: 11.0; interquartile range [10.3-11.7], P=.048). There were no significant differences between the groups in blood product transfusion (pre: 7.1% vs post: 5.1%, P=.13).CONCLUSIONImplementation of a standardized antepartum anemia protocol is associated with increased intravenous iron sucrose utilization and improvement in predelivery hemoglobin. |
ArticleNumber | 100533 |
Author | Speranza, Rosa J. Srinivas, Sindhu K. Levine, Lisa D. Hamm, Rebecca F. Wang, Eileen Y. |
Author_xml | – sequence: 1 givenname: Rebecca F. orcidid: 0000-0002-2587-2054 surname: Hamm fullname: Hamm, Rebecca F. email: Rebecca.feldmanhamm@uphs.upenn.edu organization: Maternal and Child Health Research Center, Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA – sequence: 2 givenname: Eileen Y. orcidid: 0000-0001-9643-3959 surname: Wang fullname: Wang, Eileen Y. organization: Maternal and Child Health Research Center, Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA – sequence: 3 givenname: Lisa D. orcidid: 0000-0002-6811-7980 surname: Levine fullname: Levine, Lisa D. organization: Maternal and Child Health Research Center, Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA – sequence: 4 givenname: Rosa J. surname: Speranza fullname: Speranza, Rosa J. organization: Maternal and Child Health Research Center, Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA – sequence: 5 givenname: Sindhu K. surname: Srinivas fullname: Srinivas, Sindhu K. organization: Maternal and Child Health Research Center, Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA |
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Cites_doi | 10.1067/mob.2002.121894 10.1111/trf.13252 10.1111/j.1365-2796.2010.02251.x 10.1515/jpm-2016-0389 10.1542/peds.2011-3513 10.1097/01.AOG.0000185260.82466.b4 10.1159/000089466 10.1016/j.ijgo.2007.05.011 10.1016/S1701-2163(15)30259-0 10.1080/14767058.2019.1656189 10.1111/j.1447-0756.2012.01982.x 10.1038/sj.ejcn.1600517 10.1016/j.ijoa.2021.102985 10.1016/j.ejogrb.2020.12.055 10.1097/AOG.0000000000004439 10.1097/AOG.0b013e3181809c0d 10.1016/0002-9378(91)90626-3 10.1186/1471-2393-14-8 10.1002/ajh.24361 |
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ACOG Practice Bulletin No. 95: anemia in pregnancy publication-title: Obstet Gynecol doi: 10.1097/AOG.0b013e3181809c0d – volume: 164 start-page: 59 year: 1991 ident: 10.1016/j.ajogmf.2021.100533_bib0004 article-title: Anemia and spontaneous preterm birth publication-title: Am J Obstet Gynecol doi: 10.1016/0002-9378(91)90626-3 contributor: fullname: Klebanoff – volume: 14 start-page: 8 year: 2014 ident: 10.1016/j.ajogmf.2021.100533_bib0006 article-title: Infant motor development in rural Vietnam and intrauterine exposures to anaemia, iron deficiency and common mental disorders: a prospective community-based study publication-title: BMC Pregnancy Childbirth doi: 10.1186/1471-2393-14-8 contributor: fullname: Tran – year: 2008 ident: 10.1016/j.ajogmf.2021.100533_bib0001 – volume: 91 start-page: 590 year: 2016 ident: 10.1016/j.ajogmf.2021.100533_bib0014 article-title: Safety and efficacy of rapid (1,000 mg in 1 hr) intravenous iron dextran for treatment of maternal iron deficient anemia of pregnancy publication-title: Am J Hematol doi: 10.1002/ajh.24361 contributor: fullname: Wong |
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Snippet | In randomized trials, antepartum intravenous iron sucrose is effective at improving predelivery hemoglobin in iron deficiency anemia. Yet, there is a gap... BACKGROUNDIn randomized trials, antepartum intravenous iron sucrose is effective at improving predelivery hemoglobin in iron deficiency anemia. Yet, there is a... |
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SubjectTerms | anemia Anemia - diagnosis Anemia - drug therapy Anemia - epidemiology Anemia, Iron-Deficiency - diagnosis Anemia, Iron-Deficiency - drug therapy Anemia, Iron-Deficiency - epidemiology blood transfusion Female Ferric Compounds - therapeutic use Ferric Oxide, Saccharated - therapeutic use Hematinics - therapeutic use hemoglobin Hemoglobins - analysis Hemoglobins - metabolism Hemoglobins - therapeutic use Humans intravenous iron Iron Deficiencies Male postimplementation preimplementation Prospective Studies protocol Puerperal Disorders - drug therapy Treatment Outcome |
Title | Implementation of a protocol for management of antepartum iron deficiency anemia: a prospective cohort study |
URI | https://dx.doi.org/10.1016/j.ajogmf.2021.100533 https://www.ncbi.nlm.nih.gov/pubmed/34808403 https://www.proquest.com/docview/2601481878 https://pubmed.ncbi.nlm.nih.gov/PMC9115863 |
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