The Use of Antibodies in Small-Molecule Drug Discovery

Antibodies are powerful research tools that can be used in many areas of biology to probe, measure, and perturb various biological structures. Successful drug discovery is dependent on the correct identification of a target implicated in disease, coupled with the successful selection, optimization,...

Full description

Saved in:
Bibliographic Details
Published inJournal of biomolecular screening Vol. 19; no. 6; pp. 829 - 838
Main Authors Marsden, Catherine J, Eckersley, Sonia, Hebditch, Max, Kvist, Alexander J, Milner, Roy, Mitchell, Danielle, Warwicker, Juli, Marley, Anna E
Format Journal Article
LanguageEnglish
Published United States 01.07.2014
Subjects
Animals
Animals, Genetically Modified
Antibodies - chemistry
Antibody Affinity
Crystallization
Drug Discovery - methods
Epitopes - chemistry
Humans
Immunoglobulin G - chemistry
Molecular Chaperones - chemistry
Phenotype
Protein Engineering - methods
Proteomics - methods
RNA - chemistry
phenotypic screening
drug discovery
target validation
antibody tool
review
crystallization chaperone
Online AccessGet full text

Cover

More Information
Summary:Antibodies are powerful research tools that can be used in many areas of biology to probe, measure, and perturb various biological structures. Successful drug discovery is dependent on the correct identification of a target implicated in disease, coupled with the successful selection, optimization, and development of a candidate drug. Because of their specific binding characteristics, with regard to specificity, affinity, and avidity, coupled with their amenability to protein engineering, antibodies have become a key tool in drug discovery, enabling the quantification, localization, and modulation of proteins of interest. This review summarizes the application of antibodies and other protein affinity reagents as specific research tools within the drug discovery process.
ISSN:2472-5552
1552-454X
DOI:10.1177/1087057114527770