Dihomo-γ-Linolenic Acid (20:3n-6)—Metabolism, Derivatives, and Potential Significance in Chronic Inflammation

• Published in: International journal of molecular sciences Vol. 24; no. 3; p. 2116
• Main Authors: Mustonen, Anne-Mari, Nieminen, Petteri
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.01.2023; MDPI
• Subjects: 8,11,14-Eicosatrienoic Acid; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Arachidonic Acid; Arthritis; Atherosclerosis; Biosynthesis; Body fat; Chronic Disease; Diabetes; Diabetic retinopathy; Disease; Eczema; Fatty Acid Desaturases - metabolism; Fatty acids; Fatty Acids, Omega-6; Humans; Inflammation; Inflammation - drug therapy; Inflammation - metabolism; Insulin resistance; Lipids; Metabolism; Metabolites; Obesity; Overweight; Plasma; Polyunsaturated fatty acids; Review; Smooth muscle; oxylipin; inflammation; dihomo-γ-linolenic acid; n-6 PUFA; DGLA; lipid mediator

Dihomo-γ-linolenic acid (DGLA) has emerged as a significant molecule differentiating healthy and inflamed tissues. Its position at a pivotal point of metabolic pathways leading to anti-inflammatory derivatives or via arachidonic acid (ARA) to pro-inflammatory lipid mediators makes this n-6 polyunsat...