IL-6 and TNF-α promote metastasis of lung cancer by inducing epithelial-mesenchymal transition

• Published in: Oncology letters Vol. 13; no. 6; pp. 4657 - 4660
• Main Authors: Shang, Guan-Sheng, Liu, Lunxu, Qin, Yi-Wei
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications UK Ltd 01.06.2017; D.A. Spandidos
• Subjects: Chemotherapy; Cytokines; Drug resistance; Gene expression; Laboratories; Lung cancer; Medical prognosis; Metastasis; Oncology; Proteins; Tumor necrosis factor-TNF; Tumors; Beijing China; United States > US; China; lung cancer; epithelial-mesenchymal transition; tumor necrosis factor-α; interleukin-6

The characteristics of cancer cells, such as invasiveness, are affected by the tumor microenvironment. Studies have shown that interleukin (IL)-6 and tumor necrosis factor (TNF)-α regulate the proliferation of lung cancer. However, few studies have focused on the effects of IL-6 and TNF-α on metasta...