Monoamine Oxidase B Expression Correlates with a Poor Prognosis in Colorectal Cancer Patients and Is Significantly Associated with Epithelial-to-Mesenchymal Transition-Related Gene Signatures

• Published in: International journal of molecular sciences Vol. 21; no. 8; p. 2813
• Main Authors: Yang, Yi-Chieh, Chien, Ming-Hsien, Lai, Tsung-Ching, Su, Chia-Yi, Jan, Yi-Hua, Hsiao, Michael, Chen, Chi-Long
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.04.2020; MDPI
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Adenocarcinoma - mortality; Adenocarcinoma - pathology; Antigens; Biomarkers; Chemotherapy; Colorectal cancer; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Disease; Disease-Free Survival; Epithelial-Mesenchymal Transition; Female; Gene expression; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Male; Medical prognosis; Metastasis; Monoamine Oxidase - metabolism; Neoplasm Recurrence, Local; Neoplasm Staging; Patients; Prognosis; Survival Analysis; Tissue Array Analysis; Tumors; Up-Regulation; colorectal cancer; MAOB; prognosis; epithelial-to-mesenchymal transition

Monoamine oxidases (MAOs) including MAOA and MAOB are enzymes located on the outer membranes of mitochondria, which are responsible for catalyzing monoamine oxidation. Recently, increased level of MAOs were shown in several cancer types. However, possible roles of MAOs have not yet been elucidated i...