Design and Characterization of Myristoylated and Non-Myristoylated Peptides Effective against Candida spp. Clinical Isolates

• Published in: International journal of molecular sciences Vol. 23; no. 4; p. 2164
• Main Authors: Bugli, Francesca, Massaro, Federica, Buonocore, Francesco, Saraceni, Paolo Roberto, Borocci, Stefano, Ceccacci, Francesca, Bombelli, Cecilia, Di Vito, Maura, Marchitiello, Rosalba, Mariotti, Melinda, Torelli, Riccardo, Sanguinetti, Maurizio, Porcelli, Fernando
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.02.2022; MDPI
• Subjects: Animals; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Antimicrobial agents; Bacteria; Biofilms; Candida; Candida albicans; Design; Fatty acids; Fungal infections; Fungi; Gram-positive bacteria; Humans; Larva; Lipopeptides - pharmacology; Mammals; Membranes; Microbial Sensitivity Tests; Multidrug resistant organisms; Pathogens; Peptides; Spectrum analysis; in vivo infection control; lipopeptide; myristoylation; antifungal activity

The increasing resistance of fungi to antibiotics is a severe challenge in public health, and newly effective drugs are required. Promising potential medications are lipopeptides, linear antimicrobial peptides (AMPs) conjugated to a lipid tail, usually at the N-terminus. In this paper, we investigat...