Design and Characterization of Myristoylated and Non-Myristoylated Peptides Effective against Candida spp. Clinical Isolates

The increasing resistance of fungi to antibiotics is a severe challenge in public health, and newly effective drugs are required. Promising potential medications are lipopeptides, linear antimicrobial peptides (AMPs) conjugated to a lipid tail, usually at the N-terminus. In this paper, we investigat...

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Published inInternational journal of molecular sciences Vol. 23; no. 4; p. 2164
Main Authors Bugli, Francesca, Massaro, Federica, Buonocore, Francesco, Saraceni, Paolo Roberto, Borocci, Stefano, Ceccacci, Francesca, Bombelli, Cecilia, Di Vito, Maura, Marchitiello, Rosalba, Mariotti, Melinda, Torelli, Riccardo, Sanguinetti, Maurizio, Porcelli, Fernando
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 16.02.2022
MDPI
Subjects
Animals
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Antimicrobial agents
Bacteria
Biofilms
Candida
Candida albicans
Design
Fatty acids
Fungal infections
Fungi
Gram-positive bacteria
Humans
Larva
Lipopeptides - pharmacology
Mammals
Membranes
Microbial Sensitivity Tests
Multidrug resistant organisms
Pathogens
Peptides
Spectrum analysis
in vivo infection control
lipopeptide
myristoylation
antifungal activity
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Abstract The increasing resistance of fungi to antibiotics is a severe challenge in public health, and newly effective drugs are required. Promising potential medications are lipopeptides, linear antimicrobial peptides (AMPs) conjugated to a lipid tail, usually at the N-terminus. In this paper, we investigated the in vitro and in vivo antifungal activity of three short myristoylated and non-myristoylated peptides derived from a mutant of the AMP Chionodracine. We determined their interaction with anionic and zwitterionic membrane-mimicking vesicles and their structure during this interaction. We then investigated their cytotoxic and hemolytic activity against mammalian cells. Lipidated peptides showed a broad spectrum of activity against a relevant panel of pathogen fungi belonging to Candida spp., including the multidrug-resistant C. auris. The antifungal activity was also observed vs. biofilms of C. albicans, C. tropicalis, and C. auris. Finally, a pilot efficacy study was conducted on the in vivo model consisting of Galleria mellonella larvae. Treatment with the most-promising myristoylated peptide was effective in counteracting the infection from C. auris and C. albicans and the death of the larvae. Therefore, this myristoylated peptide is a potential candidate to develop antifungal agents against human fungal pathogens.
AbstractList The increasing resistance of fungi to antibiotics is a severe challenge in public health, and newly effective drugs are required. Promising potential medications are lipopeptides, linear antimicrobial peptides (AMPs) conjugated to a lipid tail, usually at the N-terminus. In this paper, we investigated the in vitro and in vivo antifungal activity of three short myristoylated and non-myristoylated peptides derived from a mutant of the AMP Chionodracine. We determined their interaction with anionic and zwitterionic membrane-mimicking vesicles and their structure during this interaction. We then investigated their cytotoxic and hemolytic activity against mammalian cells. Lipidated peptides showed a broad spectrum of activity against a relevant panel of pathogen fungi belonging to Candida spp., including the multidrug-resistant C. auris. The antifungal activity was also observed vs. biofilms of C. albicans, C. tropicalis, and C. auris. Finally, a pilot efficacy study was conducted on the in vivo model consisting of Galleria mellonella larvae. Treatment with the most-promising myristoylated peptide was effective in counteracting the infection from C. auris and C. albicans and the death of the larvae. Therefore, this myristoylated peptide is a potential candidate to develop antifungal agents against human fungal pathogens.The increasing resistance of fungi to antibiotics is a severe challenge in public health, and newly effective drugs are required. Promising potential medications are lipopeptides, linear antimicrobial peptides (AMPs) conjugated to a lipid tail, usually at the N-terminus. In this paper, we investigated the in vitro and in vivo antifungal activity of three short myristoylated and non-myristoylated peptides derived from a mutant of the AMP Chionodracine. We determined their interaction with anionic and zwitterionic membrane-mimicking vesicles and their structure during this interaction. We then investigated their cytotoxic and hemolytic activity against mammalian cells. Lipidated peptides showed a broad spectrum of activity against a relevant panel of pathogen fungi belonging to Candida spp., including the multidrug-resistant C. auris. The antifungal activity was also observed vs. biofilms of C. albicans, C. tropicalis, and C. auris. Finally, a pilot efficacy study was conducted on the in vivo model consisting of Galleria mellonella larvae. Treatment with the most-promising myristoylated peptide was effective in counteracting the infection from C. auris and C. albicans and the death of the larvae. Therefore, this myristoylated peptide is a potential candidate to develop antifungal agents against human fungal pathogens.
The increasing resistance of fungi to antibiotics is a severe challenge in public health, and newly effective drugs are required. Promising potential medications are lipopeptides, linear antimicrobial peptides (AMPs) conjugated to a lipid tail, usually at the N-terminus. In this paper, we investigated the in vitro and in vivo antifungal activity of three short myristoylated and non-myristoylated peptides derived from a mutant of the AMP Chionodracine. We determined their interaction with anionic and zwitterionic membrane-mimicking vesicles and their structure during this interaction. We then investigated their cytotoxic and hemolytic activity against mammalian cells. Lipidated peptides showed a broad spectrum of activity against a relevant panel of pathogen fungi belonging to Candida spp., including the multidrug-resistant C. auris. The antifungal activity was also observed vs. biofilms of C. albicans, C. tropicalis, and C. auris. Finally, a pilot efficacy study was conducted on the in vivo model consisting of Galleria mellonella larvae. Treatment with the most-promising myristoylated peptide was effective in counteracting the infection from C. auris and C. albicans and the death of the larvae. Therefore, this myristoylated peptide is a potential candidate to develop antifungal agents against human fungal pathogens.
The increasing resistance of fungi to antibiotics is a severe challenge in public health, and newly effective drugs are required. Promising potential medications are lipopeptides, linear antimicrobial peptides (AMPs) conjugated to a lipid tail, usually at the N-terminus. In this paper, we investigated the in vitro and in vivo antifungal activity of three short myristoylated and non-myristoylated peptides derived from a mutant of the AMP Chionodracine . We determined their interaction with anionic and zwitterionic membrane-mimicking vesicles and their structure during this interaction. We then investigated their cytotoxic and hemolytic activity against mammalian cells. Lipidated peptides showed a broad spectrum of activity against a relevant panel of pathogen fungi belonging to Candida spp., including the multidrug-resistant C. auris . The antifungal activity was also observed vs. biofilms of C. albicans , C. tropicalis , and C. auris . Finally, a pilot efficacy study was conducted on the in vivo model consisting of Galleria mellonella larvae. Treatment with the most-promising myristoylated peptide was effective in counteracting the infection from C. auris and C. albicans and the death of the larvae. Therefore, this myristoylated peptide is a potential candidate to develop antifungal agents against human fungal pathogens.
The increasing resistance of fungi to antibiotics is a severe challenge in public health, and newly effective drugs are required. Promising potential medications are lipopeptides, linear antimicrobial peptides (AMPs) conjugated to a lipid tail, usually at the N-terminus. In this paper, we investigated the in vitro and in vivo antifungal activity of three short myristoylated and non-myristoylated peptides derived from a mutant of the AMP . We determined their interaction with anionic and zwitterionic membrane-mimicking vesicles and their structure during this interaction. We then investigated their cytotoxic and hemolytic activity against mammalian cells. Lipidated peptides showed a broad spectrum of activity against a relevant panel of pathogen fungi belonging to spp., including the multidrug-resistant . The antifungal activity was also observed vs. biofilms of , , and . Finally, a pilot efficacy study was conducted on the in vivo model consisting of larvae. Treatment with the most-promising myristoylated peptide was effective in counteracting the infection from and and the death of the larvae. Therefore, this myristoylated peptide is a potential candidate to develop antifungal agents against human fungal pathogens.
Author Buonocore, Francesco
Mariotti, Melinda
Ceccacci, Francesca
Marchitiello, Rosalba
Bombelli, Cecilia
Torelli, Riccardo
Massaro, Federica
Sanguinetti, Maurizio
Porcelli, Fernando
Saraceni, Paolo Roberto
Borocci, Stefano
Bugli, Francesca
Di Vito, Maura
AuthorAffiliation 2 Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A, Gemelli IRCCS, 00168 Rome, Italy; riccardo.torelli@policlinicogemelli.it
4 CNR—Institute for Biological Systems, Area Della Ricerca di Roma 1, SP35d 9, 00010 Montelibretti, Italy
5 CNR—Institute For Biological Systems, Sede Secondaria di Roma-Meccanismi di Reazione, c/o Università La Sapienza, 00185 Rome, Italy; francesca.ceccacci@cnr.it (F.C.); cecilia.bombelli@cnr.it (C.B.)
1 Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, 00168 Rome, Italy; francesca.bugli@unicatt.it (F.B.); wdivit@gmail.com (M.D.V.); rosalba.marchitiello01@unicatt.it (R.M.); melinda.mariotti@unicatt.it (M.M.)
3 Department for Innovation in Biological, Agrofood and Forest Systems, University of Tuscia, 01100 Viterbo, Italy; federica.massaro@studenti.unitus.it (F.M.); fbuono@unitus.it (F.B.); paoloroberto33@gmail.com (P.R.S.); borocci@unitu
AuthorAffiliation_xml – name: 3 Department for Innovation in Biological, Agrofood and Forest Systems, University of Tuscia, 01100 Viterbo, Italy; federica.massaro@studenti.unitus.it (F.M.); fbuono@unitus.it (F.B.); paoloroberto33@gmail.com (P.R.S.); borocci@unitus.it (S.B.)
– name: 5 CNR—Institute For Biological Systems, Sede Secondaria di Roma-Meccanismi di Reazione, c/o Università La Sapienza, 00185 Rome, Italy; francesca.ceccacci@cnr.it (F.C.); cecilia.bombelli@cnr.it (C.B.)
– name: 1 Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, 00168 Rome, Italy; francesca.bugli@unicatt.it (F.B.); wdivit@gmail.com (M.D.V.); rosalba.marchitiello01@unicatt.it (R.M.); melinda.mariotti@unicatt.it (M.M.)
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35216297$$D View this record in MEDLINE/PubMed
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Keywords in vivo infection control
lipopeptide
myristoylation
antifungal activity
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Snippet The increasing resistance of fungi to antibiotics is a severe challenge in public health, and newly effective drugs are required. Promising potential...
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pubmed
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StartPage 2164
SubjectTerms Animals
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Antimicrobial agents
Bacteria
Biofilms
Candida
Candida albicans
Design
Fatty acids
Fungal infections
Fungi
Gram-positive bacteria
Humans
Larva
Lipopeptides - pharmacology
Mammals
Membranes
Microbial Sensitivity Tests
Multidrug resistant organisms
Pathogens
Peptides
Spectrum analysis
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Title Design and Characterization of Myristoylated and Non-Myristoylated Peptides Effective against Candida spp. Clinical Isolates
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