The Role and Mechanism of Epithelial-to-Mesenchymal Transition in Prostate Cancer Progression

• Published in: International journal of molecular sciences Vol. 18; no. 10; p. 2079
• Main Authors: Lo, U-Ging, Lee, Cheng-Fan, Lee, Ming-Shyue, Hsieh, Jer-Tsong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.09.2017; MDPI
• Subjects: Animals; Cancer therapies; Disease Progression; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Male; Metastasis; MicroRNAs - genetics; Neoplasm Invasiveness - genetics; Neoplasm Invasiveness - pathology; Prostate - metabolism; Prostate - pathology; Prostate cancer; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Review; RNA, Long Noncoding - genetics; metastasis; prostate cancer progression; epithelial-to-mesenchymal transition

In prostate cancer (PCa), similar to many other cancers, distant organ metastasis symbolizes the beginning of the end disease, which eventually leads to cancer death. Many mechanisms have been identified in this process that can be rationalized into targeted therapy. Among them, epithelial-to-mesenc...