Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium

• Published in: Nucleic acids research Vol. 48; no. 6; pp. 2880 - 2896
• Main Authors: Li, Jun, Zhang, Ting, Ramakrishnan, Aarthi, Fritzsch, Bernd, Xu, Jinshu, Wong, Elaine Y M, Loh, Yong-Hwee Eddie, Ding, Jianqiang, Shen, Li, Xu, Pin-Xian
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 06.04.2020
• Subjects: Base Sequence; Cell Differentiation - genetics; Cell Lineage - genetics; Cell Polarity; Consensus Sequence; DNA - metabolism; Dual Specificity Phosphatase 6 - genetics; Dual Specificity Phosphatase 6 - metabolism; Enhancer Elements, Genetic - genetics; Epithelium - metabolism; Fibroblast Growth Factor 8 - genetics; Fibroblast Growth Factor 8 - metabolism; Gene Expression Regulation, Developmental; Gene regulation, Chromatin and Epigenetics; Genetic Loci; Genome; Hair Cells, Auditory - cytology; Hair Cells, Auditory - metabolism; Hair Cells, Auditory - ultrastructure; Homeodomain Proteins - metabolism; Humans; Multiprotein Complexes - metabolism; Nucleotide Motifs - genetics; Protein Binding; Signal Transduction - genetics

Abstract The transcription factor Six1 is essential for induction of sensory cell fate and formation of auditory sensory epithelium, but how it activates gene expression programs to generate distinct cell-types remains unknown. Here, we perform genome-wide characterization of Six1 binding at differe...