New insights into the evolution of human Y chromosome palindromes through mutation and gene conversion

• Published in: Human molecular genetics Vol. 30; no. 23; pp. 2272 - 2285
• Main Authors: Bonito, Maria, D’Atanasio, Eugenia, Ravasini, Francesco, Cariati, Selene, Finocchio, Andrea, Novelletto, Andrea, Trombetta, Beniamino, Cruciani, Fulvio
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 16.11.2021
• Subjects: Chromosome Mapping; Chromosomes, Human, Y; Evolution, Molecular; Gene Conversion; Genetic Variation; Humans; Inverted Repeat Sequences; Male; Mutation; Mutation Rate; Phylogeny

Abstract About one-quarter of the euchromatic portion of the male-specific region of the human Y chromosome consists of large duplicated sequences that are organized in eight palindromes (termed P1–P8), which undergo arm-to arm gene conversion, a proposed mechanism for maintaining their sequence int...