Muscle-Saturated Bioactive Lipids Are Increased with Aging and Influenced by High-Intensity Interval Training

• Published in: International journal of molecular sciences Vol. 20; no. 5; p. 1240
• Main Authors: Søgaard, Ditte, Baranowski, Marcin, Larsen, Steen, Taulo Lund, Michael, Munk Scheuer, Cathrine, Vestergaard Abildskov, Carina, Greve Dideriksen, Sofie, Dela, Flemming, Wulff Helge, Jørn
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.03.2019; MDPI
• Subjects: Adult; Aging - metabolism; Aging - physiology; Blood Glucose - metabolism; Ceramides - metabolism; Diglycerides - metabolism; Exercise - physiology; Fatty Acids - metabolism; Female; Glucose; Glucose - metabolism; High-Intensity Interval Training - methods; Humans; Insulin - metabolism; Insulin resistance; Insulin Resistance - physiology; Kinases; Lipid Metabolism - physiology; Lipids; Lipids - physiology; Male; Middle Aged; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiology; Obesity - metabolism; Obesity - physiopathology; Overweight - metabolism; Overweight - physiopathology; high-intensity interval training; ceramide; aging; insulin resistance; diacylglycerol; obesity

Ceramide and diacylglycerol are linked to insulin resistance in rodents, but in humans the data are inconsistent. Insulin resistance is frequently observed with aging, but the role of ceramide and diacylglycerol is not clarified. Training improves metabolic health and, therefore, we aimed to elucida...