Transcription, mRNA Export, and Immune Evasion Shape the Codon Usage of Viruses

• Published in: Genome biology and evolution Vol. 13; no. 9
• Main Authors: Mordstein, Christine, Cano, Laura, Morales, Atahualpa Castillo, Young, Bethan, Ho, Alexander T, Rice, Alan M, Liss, Michael, Hurst, Laurence D, Kudla, Grzegorz
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.09.2021
• Subjects: Codon - genetics; Codon Usage; Evolution, Molecular; Genome, Viral; Immune Evasion; RNA, Messenger - genetics; Viruses - genetics; gene regulation; codon usage; virus evolution

Abstract The nucleotide composition, dinucleotide composition, and codon usage of many viruses differ from their hosts. These differences arise because viruses are subject to unique mutation and selection pressures that do not apply to host genomes; however, the molecular mechanisms that underlie th...