Ant-Neointimal Formation Effects of SLC6A6 in Preventing Vascular Smooth Muscle Cell Proliferation and Migration via Wnt/β-Catenin Signaling

• Published in: International journal of molecular sciences Vol. 24; no. 3; p. 3018
• Main Authors: Rong, Zhihua, Li, Fengshi, Zhang, Rui, Niu, Shuai, Di, Xiao, Ni, Leng, Liu, Changwei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.02.2023; MDPI
• Subjects: Angioplasty; Animals; Atherosclerosis; Atherosclerosis - metabolism; beta Catenin - metabolism; Carotid arteries; Carotid Artery Injuries - metabolism; Catheters; Cell growth; Cell Movement - genetics; Cell Proliferation; Cells, Cultured; Experiments; Genotype & phenotype; Humans; Muscle, Smooth, Vascular - metabolism; Myocytes, Smooth Muscle - metabolism; Neointima - pathology; Proteins; Rats; Reactive oxygen species; Reactive Oxygen Species - metabolism; RNA, Small Interfering - metabolism; Smooth muscle; Software; Vascular System Injuries - metabolism; Wnt Signaling Pathway; Beijing China; United States > US; China; Japan; SLC6A6; neointimal formation; VSMCs; vascular remolding

Vascular smooth muscle cells (VSMCs) play an important role in the pathogenesis of vascular remolding, such as atherosclerosis and restenosis. Solute carrier family 6 member 6 (SLC6A6) is a transmembrane transporter that maintains a variety of physiological functions and is highly expressed in VSMCs...